Catalog No.
PHD82801
Species reactivity
Human, Mouse, Rat
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human PTPN6 (Phe244-Phe515).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
HCP,PTPN6,PTP1C,Hematopoietic cell protein-tyrosine phosphatase,SH-PTP1,Protein-tyrosine phosphatase SHP-1,Protein-tyrosine phosphatase 1C,Tyrosine-protein phosphatase non-receptor type 6,PTP-1C
Purification
Purified by antigen affinity column.
Accession
P29350
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
T Lymphocyte-Specific Deletion of SHP1 and SHP2 Promotes Activation-Induced Cell Death of CD4+ T Cells and Impairs Antitumor Response., PMID:39803505
Identification and experimental validation of genes associated with programmed cell death in dendritic cells of the thyroid tissue in Hashimoto's thyroiditis., PMID:39260305
Transcriptome Analysis Reveals the Induction of Apoptosis-Related Genes by a Monoclonal Antibody against a New Epitope of CD99 on T-Acute Lymphoblastic Leukemia., PMID:38804310
Hepatitis B surface antigen positivity is associated with poor short- and long-term outcomes in patients with diffuse large B-cell lymphoma who received CHOP or R-CHOP., PMID:38318173
TNFα counteracts interleukin-10 anti-inflammatory pathway through the NOX2-Lyn-SHP-1 axis in human monocytes., PMID:37757542
Combining radiation and the ATR inhibitor berzosertib activates STING signaling and enhances immunotherapy via inhibiting SHP1 function in colorectal cancer., PMID:36855844
Novel Molecular Therapies and Genetic Landscape in Selected Rare Diseases with Hematologic Manifestations: A Review of the Literature., PMID:36766791
Jmjd1c demethylates STAT3 to restrain plasma cell differentiation and rheumatoid arthritis., PMID:35995859
Interfering B cell receptor signaling via SHP-1/p-Lyn axis shows therapeutic potential in diffuse large B-cell lymphoma., PMID:35941532
Proteomic Profiling and Functional Analysis of B Cell-Derived Exosomes upon Pneumocystis Infection., PMID:35465354
A targetable LIFR-NF-κB-LCN2 axis controls liver tumorigenesis and vulnerability to ferroptosis., PMID:34921145
The Protein Tyrosine Phosphatase SHP-1 (PTPN6) but Not CD45 (PTPRC) Is Essential for the Ligand-Mediated Regulation of CD22 in BCR-Ligated B Cells., PMID:33990399
A CD22-Shp1 phosphatase axis controls integrin β7 display and B cell function in mucosal immunity., PMID:33589816
Enhanced BCR signaling inflicts early plasmablast and germinal center B cell death., PMID:33532715
Tumour targetable and microenvironment-responsive nanoparticles simultaneously disrupt the PD-1/PD-L1 pathway and MAPK/ERK/JNK pathway for efficient treatment of colorectal cancer., PMID:33233956
Shp1 Loss Enhances Macrophage Effector Function and Promotes Anti-Tumor Immunity., PMID:33133093
Regulation of autoimmune arthritis by the SHP-1 tyrosine phosphatase., PMID:32586377
BCALM (AC099524.1) Is a Human B Lymphocyte-Specific Long Noncoding RNA That Modulates B Cell Receptor-Mediated Calcium Signaling., PMID:32571842
Activation of Siglec-7 results in inhibition of in vitro and in vivo growth of human mast cell leukemia cells., PMID:32035162
Pro-efferocytic nanoparticles are specifically taken up by lesional macrophages and prevent atherosclerosis., PMID:31988506
TCDD-mediated suppression of naïve human B cell IgM secretion involves aryl hydrocarbon receptor-mediated reduction in STAT3 serine 727 phosphorylation and is restored by interferon-γ., PMID:31678681
Quantitative Interactomics in Primary T Cells Provides a Rationale for Concomitant PD-1 and BTLA Coinhibitor Blockade in Cancer Immunotherapy., PMID:31189114
Ligand Recognition Determines the Role of Inhibitory B Cell Co-receptors in the Regulation of B Cell Homeostasis and Autoimmunity., PMID:30333834
Successful Treatment of HIV-Associated Kaposi Sarcoma with Immune Checkpoint Blockade., PMID:30194084
Galectin-9 suppresses B cell receptor signaling and is regulated by I-branching of N-glycans., PMID:30120234
IL-4-Induced Gene 1: A Negative Immune Checkpoint Controlling B Cell Differentiation and Activation., PMID:29288206
Hepatic leukocyte immunoglobulin-like receptor B4 (LILRB4) attenuates nonalcoholic fatty liver disease via SHP1-TRAF6 pathway., PMID:29091299
Dengue virus compartmentalization during antibody-enhanced infection., PMID:28084461
Akt and SHP-1 are DC-intrinsic checkpoints for tumor immunity., PMID:27812544
CD72 negatively regulates B lymphocyte responses to the lupus-related endogenous toll-like receptor 7 ligand Sm/RNP., PMID:27810925
Besides an ITIM/SHP-1-dependent pathway, CD22 collaborates with Grb2 and plasma membrane calcium-ATPase in an ITIM/SHP-1-independent pathway of attenuation of Ca2+i signal in B cells., PMID:27276708
Constitutive Activation of Interleukin-13/STAT6 Contributes to Kaposi's Sarcoma-Associated Herpesvirus-Related Primary Effusion Lymphoma Cell Proliferation and Survival., PMID:26246572
Anti-CD20 Therapy Acts via FcγRIIIA to Diminish Responsiveness of Human Natural Killer Cells., PMID:26229120
Cutting Edge: Redox Signaling Hypersensitivity Distinguishes Human Germinal Center B Cells., PMID:26157177
Mir-17-92 regulates bone marrow homing of plasma cells and production of immunoglobulin G2c., PMID:25881561
Signalling thresholds and negative B-cell selection in acute lymphoblastic leukaemia., PMID:25799995
SHP-1-dependent macrophage differentiation exacerbates virus-induced myositis., PMID:25681345
Small molecule 1'-acetoxychavicol acetate suppresses breast tumor metastasis by regulating the SHP-1/STAT3/MMPs signaling pathway., PMID:25301089
Shifting FcγRIIA-ITAM from activation to inhibitory configuration ameliorates arthritis., PMID:25061875
Shp1 signalling is required to establish the long-lived bone marrow plasma cell pool., PMID:24978161
Mechanisms of Siglec-F-induced eosinophil apoptosis: a role for caspases but not for SHP-1, Src kinases, NADPH oxidase or reactive oxygen., PMID:23840825
Copresentation of antigen and ligands of Siglec-G induces B cell tolerance independent of CD22., PMID:23836061
Death receptor 5-targeted depletion of interleukin-23-producing macrophages, Th17, and Th1/17 associated with defective tyrosine phosphatase in mice and patients with rheumatoid arthritis., PMID:23818173
Megakaryocyte-specific deletion of the protein-tyrosine phosphatases Shp1 and Shp2 causes abnormal megakaryocyte development, platelet production, and function., PMID:23509158
SHPS-1 and a synthetic peptide representing its ITIM inhibit the MyD88, but not TRIF, pathway of TLR signaling through activation of SHP and PI3K in THP-1 cells., PMID:23314616
CD72 regulates the growth of KIT-mutated leukemia cell line Kasumi-1., PMID:24713856
The tyrosine phosphatase SHP-1 negatively regulates cytotrophoblast proliferation in first-trimester human placenta by modulating EGFR activation., PMID:22797910
The reversible formation of cysteine sulfenic acid promotes B-cell activation and proliferation., PMID:22674013
Immunology. When less signaling is more., PMID:22654048
B cell receptor signal transduction in the GC is short-circuited by high phosphatase activity., PMID:22555432
For research use only. Not for human or drug use.
