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Research Grade Inolimomab

Catalog #:   DHB95804 Specific References (100) DATASHEET
Host species: Mouse
Isotype: IgG1-kappa
Applications: Research Grade Biosimilar
Expression system: Mammalian Cells
Overview

Catalog No.

DHB95804

Expression system

Mammalian Cells

Species reactivity

Human

Host species

Mouse

Isotype

IgG1-kappa

Clonality

Monoclonal

Target

IL2-RA, IL-2R subunit alpha, TAC antigen, IL-2-RA, p55, IL2RA, IL-2 receptor subunit alpha, Interleukin-2 receptor subunit alpha, CD25

Concentration

1 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

P01589

Applications

Research Grade Biosimilar

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Alternative Names

CAS: 152981-31-2

Clone ID

Inolimomab

Data Image
  • SDS-PAGE
    SDS PAGE for Inolimomab
  • Bioactivity
    Detects CD25/IL2RA in indirect ELISAs.
References

Inolimomab (OPi), PMID: 12431019

A phase 3 randomized trial comparing inolimomab vs usual care in steroid-resistant acute GVHD, PMID: 27899357

Inolimomab in steroid-refractory acute graft-versus-host disease following allogeneic hematopoietic stem cell transplantation: retrospective analysis and comparison with other interleukin-2 receptor antibodies, PMID: 16210965

Long-term follow-up of a phase 3 clinical trial of inolimomab for the treatment of primary steroid refractory aGVHD, PMID: 30670534

Combination Therapy with Inolimomab and Etanercept for Severe Steroid-Refractory Acute Graft-versus-Host Disease, PMID: 26386320

Exposure-effect population model of inolimomab, a monoclonal antibody administered in first-line treatment for acute graft-versus-host disease, PMID: 17465640

Updated experience with inolimomab as treatment for corticosteroid-refractory acute graft-versus-host disease, PMID: 23178634

Inolimomab. Anti-CD25 monoclonal antibody B-B10, anti-interleukin-2 receptor monoclonal antibody B-B10, B-B10, BT 563, Leukotac, PMID: 10565995

Encouraging results with inolimomab (anti-IL-2 receptor) as treatment for refractory acute graft-versus-host disease, PMID: 17085306

Long-term follow-up of corticosteroid refractory acute GVHD treated with an Inolimomab-based algorithm: a single center experience, PMID: 23503532

Immunotherapies in dermatologic disorders, PMID: 22703856

Adverse events in second- and third-line treatments for acute and chronic graft- versus-host disease: systematic review, PMID: 33343855

Steroid-refractory acute GVHD: lack of long-term improved survival using new generation anticytokine treatment, PMID: 21736868

The use of monoclonal antibodies in immune-mediated hematologic disorders, PMID: 22703857

Gateways to clinical trials, PMID: 16894408

Gateways to clinical trials, PMID: 16801985

Patterns of infection and infection-related mortality in patients with steroid-refractory acute graft versus host disease, PMID: 27595281

[Role of monoclonal antibodies in the treatment of acute graft versus host disease], PMID: 17237003

Invasive Fungal Diseases in Children with Hematological Malignancies Treated with Therapies That Target Cell Surface Antigens: Monoclonal Antibodies, Immune Checkpoint Inhibitors and CAR T-Cell Therapies, PMID: 33807678

Immunosuppressive T-cell antibody induction for heart transplant recipients, PMID: 24297433

Interleukin-2 receptor antibody therapy, PMID: 9404968

MEK-dependent IL-8 induction regulates the invasiveness of triple-negative breast cancer cells, PMID: 26537583

IL-7 and IL-15 bypass the immunosuppressive action of anti-CD25 monoclonal antibodies, PMID: 11377516

Ten-year follow-up of a prospective, randomized trial of BT563/bb10 versus anti-thymocyte globulin as induction therapy after heart transplantation, PMID: 16962480

Long-time survival after unrelated bone marrow transplantation in children and adolescents and targeted therapy with CD25 blockade to prevent GVHD, PMID: 15175962

In vitro and in vivo effects of BT 563, an anti-interleukin-2 receptor monoclonal antibody, PMID: 11271306

IL-2 receptor antibody induction increases the risk for chronic rejection after liver transplantation, PMID: 11267360

Anti-IL-2 receptor BT563 versus placebo: a randomized trial for induction therapy after liver transplantation, PMID: 9723425

Treatment of steroid-resistant acute graft-vs-host disease after allogeneic marrow transplantation with anti-interleukin-2 receptor antibody (BT563), PMID: 7998086

Outcome following orthotopic liver transplantation in HBsAg-positive patients using short- or long-term immunoprophylaxis, PMID: 7527983

Ten-year follow-up of recipients of a kidney or heart transplant who received induction therapy with a monoclonal antibody against the interleukin-2 receptor, PMID: 15859929

Rejection prophylaxis with interleukin-2 receptor antibody BT 563: mechanisms of action on human cells, PMID: 14621910

Spontaneous proliferation of peripheral blood lymphocytes as an indicator of intragraft immune activation in liver transplant patients, PMID: 7949544

A randomized, placebo-controlled trial with anti-interleukin-2 receptor antibody for immunosuppressive induction therapy after liver transplantation, PMID: 9686324

Blockade of the interleukin (IL)-2/IL-2 receptor pathway with a monoclonal anti-IL-2 receptor antibody (BT563) does not prevent the development of acute heart allograft rejection in humans, PMID: 9484761

Treatment of acute graft-versus-host disease with methylprednisolone and cyclosporine with or without an anti-interleukin-2 receptor monoclonal antibody. A multicenter phase III study, PMID: 7491697

A prospective randomized trial comparing interleukin-2 receptor antibody versus antithymocyte globulin as part of a quadruple immunosuppressive induction therapy following orthotopic liver transplantation, PMID: 9210503

De novo malignancies after liver transplantation using tacrolimus-based protocols or cyclosporine-based quadruple immunosuppression with an interleukin-2 receptor antibody or antithymocyte globulin, PMID: 9305716

[Salvage therapy with anti-IL-2 receptor antibodies in high-risk kidney transplant patients], PMID: 9765770

A randomized trial comparing anti-interleukin-2 receptor antibody and placebo for immunosuppressive therapy after OLT, PMID: 9636586

Comparison of quadruple induction including ATG or IL-2R antibody with FK506-based therapy after liver transplantation, PMID: 9636583

Quadruple induction therapy including antithymocyte globulin or interleukin-2 receptor antibody or FK 506-based induction therapy after liver transplantation, PMID: 10083151

Common and sequential overexpression patterns of T-helper cytokines during acute (cellular) rejection, and correlation of proinflammatory cytokine expression with chronic (ductopenic) rejection of human liver allografts: a study under cyclosporine, FK 506, and quadruple BT 563 immunosuppression, PMID: 7533370

Peripheral blood monitoring during and after rejection-prophylaxis with a monoclonal anti-interleukin-2-receptor antibody in kidney and heart transplant recipients, PMID: 7879206

Interleukin-2 receptor antibody versus antithymocyte globulin as part of quadruple induction therapy after orthotopic liver transplantation: a randomized study, PMID: 8962241

Interleukin-2 receptor antibody vs ATG for induction immunosuppression after liver transplantation: initial results of a prospective randomized trial, PMID: 7878826

Antithymocyte globulin or interleukin 2 receptor antibody for immunosuppressive induction therapy after orthotopic liver transplantation: a follow-up study, PMID: 8356721

BT563 significantly decreases sIL-2R plasma levels despite acute allograft rejection, PMID: 8962203

Quadruple immunosuppression including a new IL-2-receptor antibody and the incidence of infections after liver transplantation, PMID: 14621765

Cytokine secretion capacity of mononuclear cells in renal transplant recipients: the effect of two different dose schedules, PMID: 8356715

Second-line therapy for patients with steroid-refractory aGVHD: systematic review and meta-analysis of randomized controlled trials., PMID:37409129

Meta-Analysis of Interleukin-2 Receptor Antagonists as the Treatment for Steroid-Refractory Acute Graft-Versus-Host Disease., PMID:34621279

Invasive Fungal Diseases in Children with Hematological Malignancies Treated with Therapies That Target Cell Surface Antigens: Monoclonal Antibodies, Immune Checkpoint Inhibitors and CAR T-Cell Therapies., PMID:33807678

Adverse events in second- and third-line treatments for acute and chronic graft-versus-host disease: systematic review., PMID:33343855

Long-term follow-up of a phase 3 clinical trial of inolimomab for the treatment of primary steroid refractory aGVHD., PMID:30670534

A phase 3 randomized trial comparing inolimomab vs usual care in steroid-resistant acute GVHD., PMID:27899357

Patterns of infection and infection-related mortality in patients with steroid-refractory acute graft versus host disease., PMID:27595281

MEK-dependent IL-8 induction regulates the invasiveness of triple-negative breast cancer cells., PMID:26537583

Combination Therapy with Inolimomab and Etanercept for Severe Steroid-Refractory Acute Graft-versus-Host Disease., PMID:26386320

Immunosuppressive T-cell antibody induction for heart transplant recipients., PMID:24297433

Long-term follow-up of corticosteroid refractory acute GVHD treated with an Inolimomab-based algorithm: a single center experience., PMID:23503532

Updated experience with inolimomab as treatment for corticosteroid-refractory acute graft-versus-host disease., PMID:23178634

The use of monoclonal antibodies in immune-mediated hematologic disorders., PMID:22703857

Immunotherapies in dermatologic disorders., PMID:22703856

Steroid-refractory acute GVHD: lack of long-term improved survival using new generation anticytokine treatment., PMID:21736868

Exposure-effect population model of inolimomab, a monoclonal antibody administered in first-line treatment for acute graft-versus-host disease., PMID:17465640

[Role of monoclonal antibodies in the treatment of acute graft versus host disease]., PMID:17237003

Encouraging results with inolimomab (anti-IL-2 receptor) as treatment for refractory acute graft-versus-host disease., PMID:17085306

Ten-year follow-up of a prospective, randomized trial of BT563/bb10 versus anti-thymocyte globulin as induction therapy after heart transplantation., PMID:16962480

Gateways to clinical trials., PMID:16894408

Gateways to clinical trials., PMID:16801985

Inolimomab in steroid-refractory acute graft-versus-host disease following allogeneic hematopoietic stem cell transplantation: retrospective analysis and comparison with other interleukin-2 receptor antibodies., PMID:16210965

Ten-year follow-up of recipients of a kidney or heart transplant who received induction therapy with a monoclonal antibody against the interleukin-2 receptor., PMID:15859929

Long-time survival after unrelated bone marrow transplantation in children and adolescents and targeted therapy with CD25 blockade to prevent GVHD., PMID:15175962

Inolimomab (OPi)., PMID:12431019

Chronic rejection after orthotopic liver transplantation is increased under induction therapy with interleukin-2 receptor antibody BT563., PMID:11377531

IL-7 and IL-15 bypass the immunosuppressive action of anti-CD25 monoclonal antibodies., PMID:11377516

IL-2 receptor antibody induction increases the risk for chronic rejection after liver transplantation., PMID:11267360

Impact of primary immunosuppression on the incidence of infectious complications after orthotopic liver transplantation., PMID:11120145

Inolimomab. Anti-CD25 monoclonal antibody B-B10, anti-interleukin-2 receptor monoclonal antibody B-B10, B-B10, BT 563, Leukotac., PMID:10565995

Quadruple induction therapy including antithymocyte globulin or interleukin-2 receptor antibody or FK 506-based induction therapy after liver transplantation., PMID:10083151

Indication for mycophenolate mofetil therapy in hepatitis C patients undergoing liver transplantation., PMID:9723453

Anti-IL-2 receptor BT563 versus placebo: a randomized trial for induction therapy after liver transplantation., PMID:9723425

A randomized, placebo-controlled trial with anti-interleukin-2 receptor antibody for immunosuppressive induction therapy after liver transplantation., PMID:9686324

Blockade of acute grade IV skin and eye graft-versus-host disease by anti-interleukin-2 receptor monoclonal antibody in genoidentical bone marrow transplantation setting., PMID:9677728

Immunosuppression and incidence of opportunistic pneumonias after liver transplantation., PMID:9636599

Indications for mycophenolate mofetil therapy in hepatitis C-patients undergoing liver transplantation., PMID:9636596

A randomized trial comparing anti-interleukin-2 receptor antibody and placebo for immunosuppressive therapy after OLT., PMID:9636586

Comparison of quadruple induction including ATG or IL-2R antibody with FK506-based therapy after liver transplantation., PMID:9636583

Blockade of the interleukin (IL)-2/IL-2 receptor pathway with a monoclonal anti-IL-2 receptor antibody (BT563) does not prevent the development of acute heart allograft rejection in humans., PMID:9484761

Interleukin-2 receptor antibody therapy., PMID:9404968

De novo malignancies after liver transplantation using tacrolimus-based protocols or cyclosporine-based quadruple immunosuppression with an interleukin-2 receptor antibody or antithymocyte globulin., PMID:9305716

A prospective randomized trial comparing interleukin-2 receptor antibody versus antithymocyte globulin as part of a quadruple immunosuppressive induction therapy following orthotopic liver transplantation., PMID:9210503

Rescue therapy with interleukin-2 receptor antibody in high risk kidney transplant patients: a 3-year follow-up study., PMID:9123020

[Salvage therapy with anti-IL-2 receptor antibodies in high-risk kidney transplant patients]., PMID:9765770

Long-term follow-up after induction treatment with monoclonal anti-interleukin-2 receptor antibody (BT563) in kidney allograft recipients: a double-blind, placebo-controlled trial., PMID:8962247

Influence of the anti-CD25 monoclonal antibody BT563 on clinical and biological rejection after orthotopic liver transplantation., PMID:8962244

Interleukin-2 receptor antibody versus antithymocyte globulin as part of quadruple induction therapy after orthotopic liver transplantation: a randomized study., PMID:8962241

BT563 significantly decreases sIL-2R plasma levels despite acute allograft rejection., PMID:8962203

The release of cytokines, adhesion molecules, and extracellular matrix parameters during and after reperfusion in human liver transplantation., PMID:8900313

Datasheet

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Research Grade Inolimomab.pdf

 

$ 328
Product specifications
100 μg 328 1 mg 1314

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