Development of DNA Vaccine Targeting E6 and E7 Proteins of Human Papillomavirus 16 (HPV16) and HPV18 for Immunotherapy in Combination with Recombinant Vaccinia Boost and PD-1 Antibody. PMID: 33468698
Identification of human MHC-I HPV18 E6/E7-specific CD8 + T cell epitopes and generation of an HPV18 E6/E7-expressing adenosquamous carcinoma in HLA-A2 transgenic mice. PMID: 36224625
Key Molecular Events in Cervical Cancer Development. PMID: 31319555
MicroRNA-130a regulated by HPV18 E6 promotes proliferation and invasion of cervical cancer cells by targeting TIMP2. PMID: 30906471
HPV E6/E7 promotes aerobic glycolysis in cervical cancer by regulating IGF2BP2 to stabilize m6A-MYC expression. PMID: 35002506
p16/ki67 and E6/E7 mRNA Accuracy and Prognostic Value in Triaging HPV DNA-Positive Women. PMID: 32745170
Characterization of HPV18 E6-specific T cell responses and establishment of HPV18 E6-expressing tumor model. PMID: 28599791
E6/E7 and E6* From HPV16 and HPV18 Upregulate IL-6 Expression Independently of p53 in Keratinocytes. PMID: 31396215
HPV18 Utilizes Two Alternative Branch Sites for E6*I Splicing to Produce E7 Protein. PMID: 30945125
Safety, efficacy, and immunogenicity of VGX-3100, a therapeutic synthetic DNA vaccine targeting human papillomavirus 16 and 18 E6 and E7 proteins for cervical intraepithelial neoplasia 2/3: a randomised, double-blind, placebo-controlled phase 2b trial. PMID: 26386540
IL-6/STAT3 mediates the HPV18 E6/E7 stimulated upregulation of MALAT1 gene in cervical cancer HeLa cells. PMID: 32113834
Gene Targeting of HPV18 E6 and E7 Synchronously by Nonviral Transfection of CRISPR/Cas9 System in Cervical Cancer. PMID: 31989837
Development and validation of a multiplex immunoassay for the simultaneous quantification of type-specific IgG antibodies to E6/E7 oncoproteins of HPV16 and HPV18. PMID: 32214362
Oncogenic HPV promotes the expression of the long noncoding RNA lnc-FANCI-2 through E7 and YY1. PMID: 33436409
Gene knock-out chain reaction enables high disruption efficiency of HPV18 E6/E7 genes in cervical cancer cells. PMID: 35036522
Treatment with Radix Euphorbiae Ebracteolatae Significantly Decreases the Expression of E6 and L1, and Increases the Expression of p53 and Rb in HPV18-infected Human Foreskin Keratinocytes. PMID: 30813877
Down-regulation of HPV18 E6, E7, or VEGF expression attenuates malignant biological behavior of human cervical cancer cells. PMID: 21222176
Tip60 and p300 function antagonistically in the epigenetic regulation of HPV18 E6/E7 genes in cervical cancer HeLa cells. PMID: 32399935
The E2F5 repressor is an activator of E6/E7 transcription and of the S-phase entry in HPV18-associated cells. PMID: 20639900
Pembrolizumab plus GX-188E therapeutic DNA vaccine in patients with HPV-16-positive or HPV-18-positive advanced cervical cancer: interim results of a single-arm, phase 2 trial. PMID: 33271094
The Major Constituent of Green Tea, Epigallocatechin-3-Gallate (EGCG), Inhibits the Growth of HPV18-Infected Keratinocytes by Stimulating Proteasomal Turnover of the E6 and E7 Oncoproteins. PMID: 33920477
Human Papillomavirus (HPV) 16/18 E6 Oncoprotein Expression in Infections with Single and Multiple Genotypes. PMID: 30606718
HPV16 E6 promotes cervical cancer cell migration and invasion by downregulation of NHERF1. PMID: 30230542
NF-Y loss triggers p53 stabilization and apoptosis in HPV18-positive cells by affecting E6 transcription. PMID: 27323853
Nuclear matrix protein SMAR1 represses c-Fos-mediated HPV18 E6 transcription through alteration of chromatin histone deacetylation. PMID: 25157104
STAT3 activation by E6 is essential for the differentiation-dependent HPV18 life cycle. PMID: 29630659
SAHA inhibits the transcription initiation of HPV18 E6/E7 genes in HeLa cervical cancer cells. PMID: 25300249
Immunotherapy Targeting HPV16/18 Generates Potent Immune Responses in HPV-Associated Head and Neck Cancer. PMID: 30242022
Phylogeny and Classification of Human Papillomavirus (HPV)16 and HPV18 Variants Based on E6 and L1 genes in Tunisian Women with Cervical Lesions. PMID: 30583341
Blocking activity of the HPV18 virus in cervical cancer cells using the CRISPR/Cas9 system. PMID: 31949818
HPV18 oncoproteins driven expression of PKM2 reprograms HeLa cell metabolism to maintain aerobic glycolysis and viability. PMID: 36277414
Development and validation of a multiplex qPCR assay for detection and relative quantification of HPV16 and HPV18 E6 and E7 oncogenes. PMID: 33597592
E6 Oncoproteins from High-Risk Human Papillomavirus Induce Mitochondrial Metabolism in a Head and Neck Squamous Cell Carcinoma Model. PMID: 31398842
Functional interaction of p53 with HPV18 E6, c-myc and H-ras in 3T3 cells. PMID: 1321402
CRISPR/Cas9-based inactivation of human papillomavirus oncogenes E6 or E7 induces senescence in cervical cancer cells. PMID: 34280810
[Expression of VEGF, KDR, p53, E6 HPV16 and HPV18 in vulvar and cervix cancer]. PMID: 10983377
Construction and identification of a yeast two-hybrid bait vector and its effect on the growth of yeast cells and the self-activating function of reporter genes for screening of HPV18 E6-interacting protein. PMID: 20155448
Gene expression profiles induced by E6 from non-European HPV18 variants reveals a differential activation on cellular processes driving to carcinogenesis. PMID: 22743128
A Phase 1 Trial Assessing the Safety and Tolerability of a Therapeutic DNA Vaccination Against HPV16 and HPV18 E6/E7 Oncogenes After Chemoradiation for Cervical Cancer. PMID: 32151670
Determination of Human Papillomavirus Type 18 Lineage of E6: A Population Study from Iran. PMID: 35342765
Human Papillomavirus E6 interaction with cellular PDZ domain proteins modulates YAP nuclear localization. PMID: 29346075
Notch1 signaling inhibits growth of EC109 esophageal carcinoma cells through downmodulation of HPV18 E6/E7 gene expression. PMID: 19122673
Design of a PDZbody, a bivalent binder of the E6 protein from human papillomavirus. PMID: 25797137
Genetic Variability in the E6, E7, and L1 Genes of Human Papillomavirus Types 16 and 18 among Women in Saudi Arabia. PMID: 36680149
Human papillomavirus type 18 E6*, E6, and E7 protein synthesis in cell-free translation systems and comparison of E6 and E7 in vitro translation products to proteins immunoprecipitated from human epithelial cells. PMID: 1651423
Phylogeny and polymorphism in the E6 and E7 of human papillomavirus: alpha-9 (HPV16, 31, 33, 52, 58), alpha-5 (HPV51), alpha-6 (HPV53, 66), alpha-7 (HPV18, 39, 59, 68) and alpha-10 (HPV6, 44) in women from Shanghai. PMID: 31832087
HPV18 DNA replication inactivates the early promoter P55 activity and prevents viral E6 expression. PMID: 27822719
Production of functional, stable, unmutated recombinant human papillomavirus E6 oncoprotein: implications for HPV-tumor diagnosis and therapy. PMID: 27465494
Cellular immunity induced by a novel HPV18 DNA vaccine encoding an E6/E7 fusion consensus protein in mice and rhesus macaques. PMID: 18455277
Human papillomavirus type 18 E6 and E7 genes integrate into human hepatoma derived cell line Hep G2. PMID: 22655088
HPV16 E6 Promotes the Progression of HPV Infection-Associated Cervical Cancer by Upregulating Glucose-6-Phosphate Dehydrogenase Expression. PMID: 34692493
Regulation of Na(+)-coupled glucose carrier SGLT1 by human papillomavirus 18 E6 protein. PMID: 21156162
E6 variants of human papillomavirus 18 differentially modulate the protein kinase B/phosphatidylinositol 3-kinase (akt/PI3K) signaling pathway. PMID: 19007961
Characterization of human papillomavirus (HPV) 16 E6 seropositive individuals without HPV-associated malignancies after 10 years of follow-up in the UK Biobank. PMID: 33248371
BAG3 down-modulation sensitizes HPV18(+) HeLa cells to PEITC-induced apoptosis and restores p53. PMID: 25175321
The Curcumin Analogue 1,5-Bis(2-hydroxyphenyl)-1,4-pentadiene-3-one Induces Apoptosis and Downregulates E6 and E7 Oncogene Expression in HPV16 and HPV18-Infected Cervical Cancer Cells. PMID: 26132907
Molecular dissection of the E6 PBM identifies essential residues regulating Chk1 phosphorylation and subsequent 14-3-3 recognition. PMID: 36775199
Regulation of p14ARF expression by HPV-18 E6 variants. PMID: 23918540
Development of an innovative approach for early diagnosis of cervical cancer using TCR‑like antibodies targeting HPV18 E6 and E7 peptides., PMID:40476553
[A fluorescence immunochromatography method for detection of human papillomavirus type 16 E6 and L1 proteins]., PMID:39584350
Comparison of preclinical efficacy of immunotherapies against HPV-induced cancers., PMID:38978164
Tirbanibulin decreases cell proliferation and downregulates protein expression of oncogenic pathways in human papillomavirus containing HeLa cells., PMID:38967656
T-cell immunity induced and reshaped by an anti-HPV immuno-oncotherapeutic lentiviral vector., PMID:38858404
Antibodies against high-risk human papillomavirus proteins as markers for noncervical HPV-related cancers in a Black South African population, according to HIV status., PMID:38577820
Evaluation of HPV 16 and HPV 18 Oncoprotein Expression as Alternative Diagnostic Tools in Cervical Lesion., PMID:38415538
Serologic response to human papillomavirus genotypes following vaccination: findings from the HITCH cohort study., PMID:37994805
Novel competitive enzyme-linked immunosorbent assay for the detection of the high-risk Human Papillomavirus 18 E6 oncoprotein., PMID:37582106
Phase II Trial of MEDI0457 and Durvalumab for Patients With Recurrent/Metastatic Human Papillomavirus-Associated Cancers., PMID:37104874
Human papillomavirus is an important risk factor for esophageal carcinoma in a Chinese population., PMID:36394699
Serologic Response to Human Papillomavirus Genotypes Among Unvaccinated Women: Findings From the HITCH Cohort Study., PMID:36322543
Human papillomavirus, tobacco, and poor oral hygiene can act synergetically, modulate the expression of the nuclear factor kappa B signaling pathway for the development and progression of head and neck cancer in the Pakistani population., PMID:35838554
Usefulness of high-risk HPV early oncoprotein (E6 and E7) serological markers in the detection of cervical cancer: A systematic review and meta-analysis., PMID:35641882
HPV types 16/18 L1 E6 and E7 proteins seropositivity and cervical cancer risk in HIV-positive and HIV-negative black South African women., PMID:35351184
Development of DNA Vaccine Targeting E6 and E7 Proteins of Human Papillomavirus 16 (HPV16) and HPV18 for Immunotherapy in Combination with Recombinant Vaccinia Boost and PD-1 Antibody., PMID:33468698
Pembrolizumab plus GX-188E therapeutic DNA vaccine in patients with HPV-16-positive or HPV-18-positive advanced cervical cancer: interim results of a single-arm, phase 2 trial., PMID:33271094
Characterization of human papillomavirus (HPV) 16 E6 seropositive individuals without HPV-associated malignancies after 10 years of follow-up in the UK Biobank., PMID:33248371
Immune Activation in Patients with Locally Advanced Cervical Cancer Treated with Ipilimumab Following Definitive Chemoradiation (GOG-9929)., PMID:32816895
Tip60 and p300 function antagonistically in the epigenetic regulation of HPV18 E6/E7 genes in cervical cancer HeLa cells., PMID:32399935
Development and validation of a multiplex immunoassay for the simultaneous quantification of type-specific IgG antibodies to E6/E7 oncoproteins of HPV16 and HPV18., PMID:32214362
Antibodies against human papillomavirus proteins in Barrett's dysplasia and intramucosal esophageal adenocarcinoma., PMID:32170783
A Phase 1 Trial Assessing the Safety and Tolerability of a Therapeutic DNA Vaccination Against HPV16 and HPV18 E6/E7 Oncogenes After Chemoradiation for Cervical Cancer., PMID:32151670
Safety and immunogenicity of VGX-3100 formulations in a healthy young adult population., PMID:31860383
Autocrine STAT3 activation in HPV positive cervical cancer through a virus-driven Rac1-NFκB-IL-6 signalling axis., PMID:31226168
Sexually transmitted infections and risk of epithelial ovarian cancer: results from the Nurses' Health Studies., PMID:30894687
Profiling of serum antibodies against human papillomavirus antigens in Korean women with cervical intraepithelial neoplasia and cervical cancer., PMID:30353680
Immunotherapy Targeting HPV16/18 Generates Potent Immune Responses in HPV-Associated Head and Neck Cancer., PMID:30242022
Prediction and identification of human leukocyte antigen-A2-restricted cytotoxic T lymphocyte epitope peptides from the human papillomavirus 58 E7 protein., PMID:30008894
Bispecific affibody molecule targeting HPV16 and HPV18E7 oncoproteins for enhanced molecular imaging of cervical cancer., PMID:29938318
Performance of OncoE6 cervical test with collection methods enabling self-sampling., PMID:29783960
Characterization of HPV18 E6-specific T cell responses and establishment of HPV18 E6-expressing tumor model., PMID:28599791
A Low-Cost HPV Immunochromatographic Assay to Detect High-Grade Cervical Intraepithelial Neoplasia., PMID:27764154
Generation of affibody molecules specific for HPV16 E7 recognition., PMID:27659535
Therapeutic HPV Cancer Vaccine Targeted to CD40 Elicits Effective CD8+ T-cell Immunity., PMID:27485136
Immunocytochemical study of TOP2A and Ki-67 in cervical smears from women under routine gynecological care., PMID:27175798
Mucosal alpha-papillomaviruses are not associated with esophageal squamous cell carcinomas: Lack of mechanistic evidence from South Africa, China and Iran and from a world-wide meta-analysis., PMID:26529033
A novel placental like alkaline phosphatase promoter driven transcriptional silencing combined with single chain variable fragment antibody based virosomal delivery for neoplastic cell targeting [corrected]., PMID:26242403
No causal association identified for human papillomavirus infections in lung cancer., PMID:24760422
Antibodies against high-risk human papillomavirus proteins as markers for invasive cervical cancer., PMID:24729277
Restoration of MAGI-1 expression in human papillomavirus-positive tumor cells induces cell growth arrest and apoptosis., PMID:24696483
Peroxiredoxin 3 is a novel marker for cell proliferation in cervical cancer., PMID:24648924
High-risk HPV types and head and neck cancer., PMID:24615247
Activation of interleukin-6/signal transducer and activator of transcription 3 by human papillomavirus early proteins 6 induces fibroblast senescence to promote cervical tumourigenesis through autocrine and paracrine pathways in tumour microenvironment., PMID:23953057
Evaluation of human papillomavirus antibodies and risk of subsequent head and neck cancer., PMID:23775966
Human papillomavirus infections and upper aero-digestive tract cancers: the ARCAGE study., PMID:23503618
Salivary mucoepidermoid carcinoma: demonstration of transcriptionally active human papillomavirus 16/18., PMID:23233027
High-risk human papillomavirus E6 oncoproteins interact with 14-3-3ζ in a PDZ binding motif-dependent manner., PMID:23175360
Human papillomavirus 16/18 E5 promotes cervical cancer cell proliferation, migration and invasion in vitro and accelerates tumor growth in vivo., PMID:23128977
The distribution of human papillomavirus in tissues from patients with head and neck squamous cell carcinoma., PMID:22923266
For research use only. Not for human or drug use.
