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Mouse Anti-Human PMEL17/ME20M Antibody (17A9)

Catalog #:   FHE28710 Specific References (93) DATASHEET
Host species: Mouse
Isotype: IgG2a, kappa
Applications: ELISA, FCM, IHC
Accession: P40967
Overview

Catalog No.

FHE28710

Species reactivity

Human, Mouse, Rat, Monkey

Host species

Mouse

Isotype

IgG2a, kappa

Clonality

Monoclonal

Conjugation

Unconjugated

Target

ME20M, Melanocyte protein PMEL, Silver locus protein homolog, Secreted melanoma-associated ME20 antigen, D12S53E, 95 kDa melanocyte-specific secreted glycoprotein, SILV, P100, Premelanosome protein, PMEL17, ME20S, PMEL, ME20-S, ME20-M, P26, P1, Melanocytes lineage-specific antigen GP100, Melanocyte protein Pmel 17, Melanoma-associated ME20 antigen

Concentration

1 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

P40967

Applications

ELISA, FCM, IHC

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 0.09% Sodium azide.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Clone ID

17A9

Data Image
References

[Clinicopathological features of metastatic melanoma in effusion cytology of serosal cavity]., PMID:39103266

[Clinicopathological features of metastatic melanoma in effusion cytology of serosal cavity]., PMID:39103266

PRAME and Historical Immunohistochemical Antibodies Ki-67, P16, and HMB-45 in Ambiguous Melanocytic Tumors., PMID:38916203

PRAME and Historical Immunohistochemical Antibodies Ki-67, P16, and HMB-45 in Ambiguous Melanocytic Tumors., PMID:38916203

Increased LCN2 (lipocalin 2) in the RPE decreases autophagy and activates inflammasome-ferroptosis processes in a mouse model of dry AMD., PMID:35473441

Increased LCN2 (lipocalin 2) in the RPE decreases autophagy and activates inflammasome-ferroptosis processes in a mouse model of dry AMD., PMID:35473441

Primary leptomeningeal melanomatosis successfully treated with PD-1 inhibitor pembrolizumab: A case report., PMID:33327228

Primary leptomeningeal melanomatosis successfully treated with PD-1 inhibitor pembrolizumab: A case report., PMID:33327228

Indication of Premelanosome Protein (PMEL) Expression Outside of Pigmented Bovine Skin Suggests Functions Beyond Eumelanogenesis., PMID:32668786

CD10 and p63 expression in a sarcomatoid undifferentiated melanoma: A cautionary (and molecularly annotated) tale., PMID:31943331

CD10 and p63 expression in a sarcomatoid undifferentiated melanoma: A cautionary (and molecularly annotated) tale., PMID:31943331

PNL2: A Useful Adjunct Biomarker to HMB45 in the Diagnosis of Uterine Perivascular Epithelioid Cell Tumor (PEComa)., PMID:31851063

PNL2: A Useful Adjunct Biomarker to HMB45 in the Diagnosis of Uterine Perivascular Epithelioid Cell Tumor (PEComa)., PMID:31851063

Utility of p16-Ki-67-HMB45 score in sorting benign from malignant Spitz tumors., PMID:31351802

Utility of p16-Ki-67-HMB45 score in sorting benign from malignant Spitz tumors., PMID:31351802

ABCB6 Resides in Melanosomes and Regulates Early Steps of Melanogenesis Required for PMEL Amyloid Matrix Formation., PMID:29940187

ABCB6 Resides in Melanosomes and Regulates Early Steps of Melanogenesis Required for PMEL Amyloid Matrix Formation., PMID:29940187

Radiologic and Histopathologic Correlation of Different Growth Patterns of Metastatic Uveal Melanoma to the Liver., PMID:29122287

Radiologic and Histopathologic Correlation of Different Growth Patterns of Metastatic Uveal Melanoma to the Liver., PMID:29122287

Hepatic perivascular epithelioid cell tumor (PEComa): a case report with a review of literatures., PMID:28288506

Hepatic perivascular epithelioid cell tumor (PEComa): a case report with a review of literatures., PMID:28288506

Increased Activity and Number of Epidermal Melanocytes in Lesional Psoriatic Skin., PMID:27497917

Increased Activity and Number of Epidermal Melanocytes in Lesional Psoriatic Skin., PMID:27497917

Hashimoto's thyroiditis could be secondary to vitiligo: the possibility of antigen crossover and oxidative stress between the two diseases., PMID:27020052

Hashimoto's thyroiditis could be secondary to vitiligo: the possibility of antigen crossover and oxidative stress between the two diseases., PMID:27020052

Metastatic melanoma of the tongue: a case report with immunohistochemical profile., PMID:25427453

Metastatic melanoma of the tongue: a case report with immunohistochemical profile., PMID:25427453

Antibody αPEP13h reacts with lymphangioleiomyomatosis cells in lung nodules., PMID:25411763

Antibody αPEP13h reacts with lymphangioleiomyomatosis cells in lung nodules., PMID:25411763

Hyperosmotic stress reduces melanin production by altering melanosome formation., PMID:25170965

A monoclonal antibody against PMEL., PMID:25118787

A monoclonal antibody against PMEL., PMID:25118787

Marginal and joint distributions of S100, HMB-45, and Melan-A across a large series of cutaneous melanomas., PMID:23899062

Marginal and joint distributions of S100, HMB-45, and Melan-A across a large series of cutaneous melanomas., PMID:23899062

Value of melanocytic-associated immunohistochemical markers in the diagnosis of malignant melanoma: a review and update., PMID:23648379

Value of melanocytic-associated immunohistochemical markers in the diagnosis of malignant melanoma: a review and update., PMID:23648379

[Detection of serum autoantibodies against premelanosome protein 17 increases in the vitiligo patients]., PMID:23643172

[Detection of serum autoantibodies against premelanosome protein 17 increases in the vitiligo patients]., PMID:23643172

Metastatic melanoma presenting as an isolated breast tumor: a study of 20 cases with emphasis on several primary mimickers., PMID:23276173

The melanosomal protein PMEL17 as a target for antibody drug conjugate therapy in melanoma., PMID:22613716

The melanosomal protein PMEL17 as a target for antibody drug conjugate therapy in melanoma., PMID:22613716

Perivascular epithelioid cell tumor (PEComa) of gynecologic origin: a clinicopathological study of three cases., PMID:22439417

Perivascular epithelioid cell tumor (PEComa) of gynecologic origin: a clinicopathological study of three cases., PMID:22439417

A mouse model of vitiligo with focused epidermal depigmentation requires IFN-γ for autoreactive CD8⁺ T-cell accumulation in the skin., PMID:22297636

A mouse model of vitiligo with focused epidermal depigmentation requires IFN-γ for autoreactive CD8⁺ T-cell accumulation in the skin., PMID:22297636

Aberrant expression of HMB-45 in traumatized melanocytic nevi., PMID:22285619

Aberrant expression of HMB-45 in traumatized melanocytic nevi., PMID:22285619

Epithelioid angiosarcoma of bone and soft tissue: a report of seven cases with emphasis on morphologic diversity, immunohistochemical features and clinical outcome., PMID:22158488

Epithelioid angiosarcoma of bone and soft tissue: a report of seven cases with emphasis on morphologic diversity, immunohistochemical features and clinical outcome., PMID:22158488

Primary oral melanoma: a histopathological and immunohistochemical study of 22 cases of Latin America., PMID:22143732

Primary oral melanoma: a histopathological and immunohistochemical study of 22 cases of Latin America., PMID:22143732

The use of immunocytochemical study in the cytologic diagnosis of melanoma: evaluation of three antibodies., PMID:22021247

The use of immunocytochemical study in the cytologic diagnosis of melanoma: evaluation of three antibodies., PMID:22021247

Melanoma-associated antigen expression in lymphangioleiomyomatosis renders tumor cells susceptible to cytotoxic T cells., PMID:19893037

Melanoma-associated antigen expression in lymphangioleiomyomatosis renders tumor cells susceptible to cytotoxic T cells., PMID:19893037

The secreted form of a melanocyte membrane-bound glycoprotein (Pmel17/gp100) is released by ectodomain shedding., PMID:19884326

The secreted form of a melanocyte membrane-bound glycoprotein (Pmel17/gp100) is released by ectodomain shedding., PMID:19884326

Impact of a recombinant fowlpox vaccine on the efficacy of adoptive cell therapy with tumor infiltrating lymphocytes in a patient with metastatic melanoma., PMID:19752747

Impact of a recombinant fowlpox vaccine on the efficacy of adoptive cell therapy with tumor infiltrating lymphocytes in a patient with metastatic melanoma., PMID:19752747

No correlation between clinical response to CTLA-4 blockade and presence of NY-ESO-1 antibody in patients with metastatic melanoma., PMID:19752745

No correlation between clinical response to CTLA-4 blockade and presence of NY-ESO-1 antibody in patients with metastatic melanoma., PMID:19752745

Expression hierarchy of T cell epitopes from melanoma differentiation antigens: unexpected high level presentation of tyrosinase-HLA-A2 Complexes revealed by peptide-specific, MHC-restricted, TCR-like antibodies., PMID:19414786

Gpnmb is a melanosome-associated glycoprotein that contributes to melanocyte/keratinocyte adhesion in a RGD-dependent fashion., PMID:19320736

Gpnmb is a melanosome-associated glycoprotein that contributes to melanocyte/keratinocyte adhesion in a RGD-dependent fashion., PMID:19320736

Granular cell tumor of the oral cavity: updated immunohistochemical profile., PMID:19192059

Granular cell tumor of the oral cavity: updated immunohistochemical profile., PMID:19192059

Improved tumor immunity using anti-tyrosinase related protein-1 monoclonal antibody combined with DNA vaccines in murine melanoma., PMID:19047169

Improved tumor immunity using anti-tyrosinase related protein-1 monoclonal antibody combined with DNA vaccines in murine melanoma., PMID:19047169

Novel approach to the characterization of melanoma associated-peptide-specific CTL lines from Japanese metastatic melanoma patients., PMID:18695871

Novel approach to the characterization of melanoma associated-peptide-specific CTL lines from Japanese metastatic melanoma patients., PMID:18695871

Nuclear to non-nuclear Pmel17/gp100 expression (HMB45 staining) as a discriminator between benign and malignant melanocytic lesions., PMID:18552823

Nuclear to non-nuclear Pmel17/gp100 expression (HMB45 staining) as a discriminator between benign and malignant melanocytic lesions., PMID:18552823

The silver locus product (Silv/gp100/Pmel17) as a new tool for the analysis of melanosome transfer in human melanocyte-keratinocyte co-culture., PMID:18331332

The silver locus product (Silv/gp100/Pmel17) as a new tool for the analysis of melanosome transfer in human melanocyte-keratinocyte co-culture., PMID:18331332

Premelanosome amyloid-like fibrils are composed of only golgi-processed forms of Pmel17 that have been proteolytically processed in endosomes., PMID:17991747

Premelanosome amyloid-like fibrils are composed of only golgi-processed forms of Pmel17 that have been proteolytically processed in endosomes., PMID:17991747

Programmed death-1 blockade enhances expansion and functional capacity of human melanoma antigen-specific CTLs., PMID:17898045

Functional up-regulation of human leukocyte antigen class I antigens expression by 5-aza-2'-deoxycytidine in cutaneous melanoma: immunotherapeutic implications., PMID:17545540

Functional up-regulation of human leukocyte antigen class I antigens expression by 5-aza-2'-deoxycytidine in cutaneous melanoma: immunotherapeutic implications., PMID:17545540

Biomarker discovery from uveal melanoma secretomes: identification of gp100 and cathepsin D in patient serum., PMID:17539671

Biomarker discovery from uveal melanoma secretomes: identification of gp100 and cathepsin D in patient serum., PMID:17539671

Immunological activation following transcutaneous delivery of HR-gp100 protein., PMID:17493711

Immunological activation following transcutaneous delivery of HR-gp100 protein., PMID:17493711

Melanocortin 1 receptor is expressed by uveal malignant melanoma and can be considered a new target for diagnosis and immunotherapy., PMID:17325166

Sialylated core 1 O-glycans influence the sorting of Pmel17/gp100 and determine its capacity to form fibrils., PMID:17303571

Melanocortin 1 receptor is expressed by uveal malignant melanoma and can be considered a new target for diagnosis and immunotherapy., PMID:17325166

Presentation of tumor antigens by dendritic cells genetically modified with viral and nonviral vectors., PMID:17063124

Presentation of tumor antigens by dendritic cells genetically modified with viral and nonviral vectors., PMID:17063124

Analysis of antitumor activity elicited by vaccination with combinations of interleukin-12 DNA with gp100 DNA or the chemokine CCL21 in vivo., PMID:16942445

Analysis of antitumor activity elicited by vaccination with combinations of interleukin-12 DNA with gp100 DNA or the chemokine CCL21 in vivo., PMID:16942445

Desmoplastic melanoma: comparison of expression of differentiation antigens and cancer testis antigens., PMID:16845331

Desmoplastic melanoma: comparison of expression of differentiation antigens and cancer testis antigens., PMID:16845331

The repeat domain of the melanosomal matrix protein PMEL17/GP100 is required for the formation of organellar fibers., PMID:16682408

Datasheet
$ 225
Product specifications
50 μg 225 100 μg 372

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For research use only. Not for human or drug use.

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Mouse Anti-Human PMEL17/ME20M Antibody (17A9) [FHE28710]
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