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Recombinant EBV/HHV4 EBNA1/BKRF1 Protein, N-His

Catalog #:   YVV15301 Specific References (94) DATASHEET
Applications: ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Expression system: E. coli
Accession: P03211
Protein length: His468-Pro607
Overview

Catalog No.

YVV15301

Expression system

E. coli

Species

Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4)

Protein length

His468-Pro607

Predicted molecular weight

17.52 kDa

Nature

Recombinant

Endotoxin level

Please contact with the lab for this information.

Purity

>90% as determined by SDS-PAGE.

Accession

P03211

Applications

ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress

Form

Lyophilized

Storage buffer

Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.

Reconstitution

Reconstitute in sterile water for a stock solution.

Shipping

In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Alternative Names

Epstein-Barr nuclear antigen 1, EBNA-1, EBV nuclear antigen 1, EBNA1, BKRF1

Data Image
  • SDS-PAGE
    SDS PAGE for Recombinant Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) EBNA1/BKRF1 protein
References

Epstein-Barr virus and multiple sclerosis. PMID: 35931816

EBNA1. PMID: 26428370

Epstein Barr Virus: Development of Vaccines and Immune Cell Therapy for EBV-Associated Diseases. PMID: 34691042

Chromosomal fragile site breakage by EBV-encoded EBNA1 at clustered repeats. PMID: 37046091

EBNA1-targeted inhibitors: Novel approaches for the treatment of Epstein-Barr virus-associated cancers. PMID: 30555548

Role of EBNA1 in NPC tumourigenesis. PMID: 22206863

Epstein-Barr virus-encoded EBNA1 and ZEBRA: targets for therapeutic strategies against EBV-carrying cancers. PMID: 25186125

Cryo-EM Structure and Functional Studies of EBNA1 Binding to the Family of Repeats and Dyad Symmetry Elements of Epstein-Barr Virus oriP. PMID: 36037477

EBNA1 and host factors in Epstein-Barr virus latent DNA replication. PMID: 23031715

Carcinoma-risk variant of EBNA1 deregulates Epstein-Barr Virus episomal latency. PMID: 28077791

Cross-reactive EBNA1 immunity targets alpha-crystallin B and is associated with multiple sclerosis. PMID: 37196088

Targeted disruption of EBNA1 in EBV-infected cells attenuated cell growth. PMID: 26879316

The Epstein-Barr virus EBNA1 protein modulates the alternative splicing of cellular genes. PMID: 30832682

Potential cellular functions of Epstein-Barr Nuclear Antigen 1 (EBNA1) of Epstein-Barr Virus. PMID: 23325328

Contributions of Epstein-Barr nuclear antigen 1 (EBNA1) to cell immortalization and survival. PMID: 23170171

EBV-encoded EBNA1 regulates cell viability by modulating miR34a-NOX2-ROS signaling in gastric cancer cells. PMID: 29061308

EBNA2 and Its Coactivator EBNA-LP. PMID: 26428371

Targeting Epstein-Barr virus to treat MS. PMID: 35590190

Analysis of the mechanism regulating the killing effect of EBNA1 on EBV-associated B-cell tumors. PMID: 36800829

Computational analysis of EBNA1 "druggability" suggests novel insights for Epstein-Barr virus inhibitor design. PMID: 27048620

Control of Viral Latency by Episome Maintenance Proteins. PMID: 31624007

Epstein-Barr virus EBNA1 protein regulates viral latency through effects on let-7 microRNA and dicer. PMID: 25031339

EBNA1 regulates cellular gene expression by binding cellular promoters. PMID: 20080792

Roscovitine inhibits EBNA1 serine 393 phosphorylation, nuclear localization, transcription, and episome maintenance. PMID: 21209116

4C Analysis of EBV-Host DNA Interactome. PMID: 36534285

Type I arginine methyltransferases are intervention points to unveil the oncogenic Epstein-Barr virus to the immune system. PMID: 36350639

FR-like EBNA1 binding repeats in the human genome. PMID: 20655080

EBNA1 and LMP1 variants in multiple sclerosis cases and controls. PMID: 20636447

Structural and Functional Basis for an EBNA1 Hexameric Ring in Epstein-Barr Virus Episome Maintenance. PMID: 28701406

The EBNA1 protein of Epstein-Barr virus functionally interacts with Brd4. PMID: 18922874

Epstein-Barr Virus and Multiple Sclerosis: New Light on an Old Idea BjornevikKCorteseMHealyBCKuhleJMinaMJLengY, and others. 2022. Longitudinal analysis reveals high prevalence of Epstein-Barr virus associated with multiple sclerosis. Science375(6578):296-301. LanzTVBrewerRCHoPPMoonJSJudeKMFernandezD, and others. Clonally expanded B cells in multiple sclerosis bind EBV EBNA1 and GlialCAM. Nature2022;603:321-7. PMID: 35441540

Functions of the Epstein-Barr virus EBNA1 protein in viral reactivation and lytic infection. PMID: 22491455

Large-scale Epstein-Barr virus EBNA1 protein purification. PMID: 18848996

Phosphorylation sites of Epstein-Barr virus EBNA1 regulate its function. PMID: 19439552

Dominant-negative derivative of EBNA1 represses EBNA1-mediated transforming gene expression during the acute phase of Epstein-Barr virus infection independent of rapid loss of viral genome. PMID: 20132216

The affinity of EBNA1 for its origin of DNA synthesis is a determinant of the origin's replicative efficiency. PMID: 18385243

EBNA1 efficiently assembles on chromatin containing the Epstein-Barr virus latent origin of replication. PMID: 14585343

DNA ligand designed to antagonize EBNA1 represses Epstein-Barr virus-induced immortalization. PMID: 21910783

[Mechanisms of EBV-mediated oncogenesis]. PMID: 17446669

EBNA1-mediated recruitment of a histone H2B deubiquitylating complex to the Epstein-Barr virus latent origin of DNA replication. PMID: 19834552

The sequence analysis of Epstein-Barr virus EBNA1 gene: could viral screening markers for nasopharyngeal carcinoma be identified? PMID: 30203133

Nucleoside diphosphate kinase/Nm23 and Epstein-Barr virus. PMID: 19412732

EBNA1-specific luminescent small molecules for the imaging and inhibition of latent EBV-infected tumor cells. PMID: 24821080

Functional analyses of the EBNA1 origin DNA binding protein of Epstein-Barr virus. PMID: 10799567

Dihydrotestosterone-androgen receptor signaling suppresses EBV-positive gastric cancer through DNA demethylation-mediated viral reactivation., PMID:40504439

Inhibitory effect of recombinant BCG containing the fusion gene BFNA on EB virus-positive tumors., PMID:40459582

EBV Vaccines in the Prevention and Treatment of Nasopharyngeal Carcinoma., PMID:40432090

Gastric Carcinoma., PMID:40423781

EBNA1., PMID:40399573

Virus-specific antibody responses in multiple sclerosis patients treated with Ocrevus., PMID:40398376

Epstein-Barr virus nuclear antigen 1 (EBNA1) increases the expression levels of MDM2 and MDM4 genes in HeLa cells: a review on MDM2 and MDM4 roles in cancer., PMID:40382619

Acute infectious mononucleosis generates persistent, functional EBNA-1 antibodies with high cross-reactivity to alpha-crystalline beta., PMID:40372913

STAT3, MYC, and EBNA1 cooperate through a ZC3H18 transcriptional network to regulate survival and proliferation of EBV-positive lymphomas., PMID:40354417

[Multiple sclerosis and the Epstein-Barr Virus: Current perspectives on their pathogenic mechanisms]., PMID:40279402

Paediatric autoimmune uveitis is associated with intraocular antibodies against Epstein-Barr virus Nuclear Antigen 1 (EBNA-1)., PMID:40239467

Co-infections and Reactivation of some Herpesviruses (HHV) and Measles Virus (MeV) in Egyptian Cancer Patients infected with Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)., PMID:40214827

Virus-specific antibody responses in severe acute respiratory syndrome coronavirus 2-infected and vaccinated individuals., PMID:40157431

Epstein-Barr virus and the immune microenvironment in multiple sclerosis: Insights from high-dimensional brain tissue imaging., PMID:40063794

Antibody reactivity against EBNA1 and GlialCAM differentiates multiple sclerosis patients from healthy controls., PMID:40063790

Epstein-Barr virus hijacks histone demethylase machinery to drive epithelial malignancy progression through KDM5B upregulation., PMID:40059116

A Bidirectional Mendelian Randomization Study on the Causal Relationship Between Epstein-Barr Virus Antibodies and Prostate Cancer Risk., PMID:40026212

SFRP2 mediates Epstein-Barr virus and bladder cancer risk: a Mendelian randomization study and colocalization analysis., PMID:40016549

Genetic evidence identifies a causal relationship between EBV infection and multiple myeloma risk., PMID:39984542

EBNA1 Targeted Ultra-Small Near-Infrared Persistent Luminescent Nano-Inhibitor for Theranostics of EBV-Associated Cancer., PMID:39972676

Autoimmune responses to myelin-associated proteins as diagnostic and prognostic biomarkers of relapsing-remitting multiple sclerosis: Associations with human herpesvirus-6 and Epstein-Barr virus reactivation., PMID:39965730

Differential antibody response to EBV proteome following EBVST immunotherapy in EBV-associated lymphomas., PMID:39908567

Epstein-Barr virus-infected nasopharyngeal carcinoma therapeutics: oncoprotein targets and clinical implications., PMID:39888474

Contribution of Blood Biomarkers to Multiple Sclerosis Diagnosis., PMID:39879564

Antibody response to Plasmodium vivax in the context of Epstein-Barr virus (EBV) co-infection: A 14-year follow-up study in the Amazon rainforest., PMID:39879169

Interplay of aurora kinase a functional residues and Epstein-barr Nuclear Antigen 1 in Epstein-barr virus associated Gastric cancer using AGS cells., PMID:39856614

Interpreting the role of epigallocatechin-3-gallate in Epstein-Barr virus infection-mediated neuronal diseases., PMID:39849283

Epigenetic and epitranscriptomic regulation during oncogenic γ-herpesvirus infection., PMID:39839102

First-in-Human Clinical Trial of a Small-Molecule EBNA1 Inhibitor, VK-2019, in Patients with Epstein-Barr-Positive Nasopharyngeal Cancer, with Pharmacokinetic and Pharmacodynamic Studies., PMID:39831818

USP7 Inhibitors Destabilize EBNA1 and Suppress Epstein-Barr Virus Tumorigenesis., PMID:39821265

Exploring the role of Epstein-Barr virus infection on the clinical features and survival in locally advanced cervical cancer: a retrospective cohort study., PMID:39777354

EBV-specific T-cell immunity: relevance for multiple sclerosis., PMID:39776919

Epstein-Barr Virus BRRF1 Induces Butyrophilin 2A1 in Nasopharyngeal Carcinoma NPC43 Cells via the IL-22/JAK3-STAT3 Pathway., PMID:39769218

Acute infectious mononucleosis generates persistent, functional EBNA-1 antibodies with high cross-reactivity to alpha crystalline beta., PMID:39763959

Intelligent Hierarchical Targeting Near-Infrared Persistent Luminescence Nanosystem for Improved Nuclear Delivery and Simultaneous Visualization/Therapy of EBV-Associated Cancer., PMID:39752553

In-depth analysis of serum antibodies against Epstein-Barr virus lifecycle proteins, and EBNA1, ANO2, GlialCAM and CRYAB peptides in patients with multiple sclerosis., PMID:39742283

Epstein-Barr virus infection in patients with MOGAD., PMID:39668776

Increased EBNA1-specific antibody response in primary-progressive multiple sclerosis., PMID:39666032

Previously unreported Arg594Lys in EBNA-1 and Leu212 in EBNA-2 among patients with EBV-associated infectious mononucleosis in Croatia., PMID:39647280

Epstein-Barr nuclear antigen 1 antibody-based indices are increased in patients with multiple sclerosis., PMID:39577298

Epstein Barr virus: A cellular hijacker in cancer., PMID:39549877

Repurposing of drug candidates against Epstein-Barr virus: Virtual screening, docking computations, molecular dynamics, and quantum mechanical study., PMID:39546470

Use of antibodies against Epstein-Barr virus nuclear antigen 1 for detection of cellular proteins with monomethylated arginine residues that are potentially involved in viral transformation., PMID:39514105

Does Epstein-Barr virus and intracellular Toll-like receptors affect the course of Hashimoto disease? Findings from studies on newly-diagnosed patients., PMID:39508448

Evidence that autoantibody production may be driven by acute Epstein-Barr virus infection in Sjögren's disease., PMID:39472059

Pre-Defined Stem-Loop Structure Library for the Discovery of L-RNA Aptamers that Target RNA G-Quadruplexes., PMID:39462761

Exploring marine natural products for identifying putative candidates as EBNA1 inhibitors: An insight from molecular docking, molecular dynamics, and DFT computations., PMID:39437701

Characterization of anti-EBNA-1 antibodies and exploration of their molecular mimicry potential in an EBV-infected Sjögren's syndrome patient., PMID:39427375

Greater humoral EBV response may be associated with choroid plexus inflammation in progressive MS., PMID:39420132

Impact of Epstein-Barr Virus Nuclear Antigen 1 on Neuroinflammation in PARK2 Knockout Mice., PMID:39409029

Datasheet
$ 313
Product specifications
100 μg 313 1 mg 1629

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For research use only. Not for human or drug use.

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Recombinant EBV/HHV4 EBNA1/BKRF1 Protein, N-His [YVV15301]
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