Catalog No.
YHG52101
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Gly108-Gly231
Predicted molecular weight
16.32 kDa
Nature
Recombinant
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q13422
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Ikaros family zinc finger protein 1, LYF1, ZNFN1A1, DNA-binding protein Ikaros, IKAROS, Lymphoid transcription factor LyF-1, IKZF1, IK1
Note
For research use only.
Frequency of polymorphisms in the IKZF1 and CDKN2A/2B genes and descriptive analysis in pediatric patients with acute lymphoblastic leukemia: a multicenter hospital-based prevalence study in Rio De Janeiro., PMID:39390455
Structure-Activity Relationship of Potent, Selective, and Orally Bioavailable Molecular Glue Degraders of CK1α., PMID:39411539
Conserved helical motifs in the IKZF1 disordered region mediate NuRD interaction and transcriptional repression., PMID:39437550
Degradation of IKZF1 prevents epigenetic progression of T cell exhaustion in an antigen-specific assay., PMID:39486420
YTHDF2 upregulation and subcellular localization dictate CD8 T cell polyfunctionality in anti-tumor immunity., PMID:39500904
Identification of small molecule agonists of fetal hemoglobin expression for the treatment of sickle cell disease., PMID:39504332
Optical Genome Mapping for Detection of BCR::ABL1-Another Tool in Our Toolbox., PMID:39596557
Tango6 regulates HSPC proliferation and definitive haematopoiesis via Ikzf1 and Cmyb in caudal haematopoietic tissue., PMID:39620979
Clinical characteristics and prognostic analysis of CDKN2A/2B gene in pediatric acute lymphoblastic leukemia: a retrospective case-control study., PMID:39676312
Targeting IKZF1 via HDAC1: Combating Acute Myeloid Leukemia., PMID:39679961
Increased CSN5 expression enhances the sensitivity to lenalidomide in multiple myeloma cells., PMID:39687025
Alterations of the IKZF1-IKZF2 tandem in immune cells of schizophrenia patients regulate associated phenotypes., PMID:39695786
Polymorphisms within genes encoding Ikaros family proteins IKZF1 and IKZF3 in multiple myeloma patients treated with thalidomide., PMID:39704419
Predictive biosignatures for hospitalization in patients with virologically confirmed COVID-19., PMID:39730204
A new pipeline SPICE identifies novel JUN-IKZF1 composite elements., PMID:39763964
A new pipeline SPICE identifies novel JUN-IKZF1 composite elements., PMID:39786853
Refining Risk Stratification for B-cell Precursor Adult Acute Lymphoblastic Leukemia Treated With a Pediatric-inspired Regimen by Combining IKZF1 Deletion and Minimal Residual Disease., PMID:39798801
Adult patients with Philadelphia chromosome positive acute lymphoblastic leukemia undergoing allogeneic hematopoietic stem cell transplantation and tyrosine kinase inhibitors: development and validation of a clinical prediction model based on cytogenetics, IKZF1 deletions and minimal residual disease., PMID:39843812
Targeting the IKZF1/BCL-2 axis as a novel therapeutic strategy for treating acute T-cell lymphoblastic leukemia., PMID:39862423
IKZF1 promotes pyroptosis and prevents M2 macrophage polarization by inhibiting JAK2/STAT5 pathway in colon cancer., PMID:39862997
The histone demethylase KDM5C enhances the sensitivity of acute myeloid leukemia cells to lenalidomide by stabilizing cereblon., PMID:39881283
Targeting Ikaros and Aiolos with pomalidomide fails to reactivate or induce apoptosis of the latent HIV reservoir., PMID:39902962
Characterization of CK2, MYC and ERG Expression in Biological Subgroups of Children with Acute Lymphoblastic Leukemia., PMID:39940843
Innovative Protein Degraders for Targeted Cancer and Viral Therapy., PMID:39967647
Methionine intervention induces PD-L1 expression to enhance the immune checkpoint therapy response in MTAP-deleted osteosarcoma., PMID:39983717
Integrative systems biology framework discovers common gene regulatory signatures in mechanistically distinct inflammatory skin diseases., PMID:40016271
Clinical characteristics and prognosis of ALL in children with CDKN2A/B gene deletion., PMID:40017529
Responsiveness of systemic lupus erythematosus subjects to iberdomide based on molecular endotypes., PMID:40021405
IKAROS protein stability is regulated by its early N-terminal region and C-terminal dimerization domain., PMID:40024461
JAK inhibitor ameliorates inflammatory bowel disease in a patient with IKZF1 haploinsufficiency., PMID:40037506
The IKZF1 N159S mutation is associated with poor outcome and a distinct molecular profile in adult patients with AML., PMID:40041934
Lactylation-related genes serve as potential markers for the diagnosis and immune infiltration in rheumatoid arthritis., PMID:40048636
Monoselective Histone Deacetylase 6 PROTAC Degrader Shows In Vivo Tractability., PMID:40063353
Early Diagnosis of Colorectal Cancer via Plasma-Derived SDC2, KCNQ5, and IKZF1 Methylation Levels., PMID:40066557
IKZF1 and Ikaros Overexpression Results in Alopecia Areata-Like Phenotype in Mice., PMID:40066904
Can we develop effective direct or indirect inhibitors of transcription factors? On the clinical evolution of protein degraders for multiple myeloma therapy., PMID:40122131
Dual CARM1-and IKZF3-targeting: A novel approach to multiple myeloma therapy synergy between CARM1 inhibition and IMiDs., PMID:40123976
Cereblon E3 ligase complex genes are expressed in tissues sensitive to thalidomide in chicken and zebrafish embryos but are unchanged following thalidomide exposure., PMID:40158790
Effective Utilization of a Customized Targeted Hybrid Capture RNA Sequencing in the Routine Molecular Categorization of Adolescent and Adult B-Lineage Acute Lymphoblastic Leukemia: A Real-World Experience., PMID:40186692
Circulating Tumor DNA in Addition to Fecal Immunochemical Test in a Dual-Test Colorectal Cancer Screening Approach., PMID:40204621
Investigating the impact of IKZF1 SNPs rs4132601 and rs11978267 on acute lymphoblastic leukemia: a comprehensive meta-analysis., PMID:40214839
IKAROS levels are associated with antigen escape in CD19- and CD22-targeted therapies for B-cell malignancies., PMID:40268897
Effects of Ikaros (IKZF1) gene in the virulence of Marek's disease virus., PMID:40318245
Overcoming CK1α liability in the discovery of a series of isoIndolinone Glutarimides as selective IKZF2 molecular glue degraders., PMID:40334997
IKZF1 as a potential therapeutic target for dendritic cell-mediated immunotherapy in IgA nephropathy., PMID:40336063
Thymic Bmi-1 hampers γδT17 generation and its derived RORγt-IL-17A signaling to delay cardiac aging., PMID:40366697
Molecular characterization and predictors of relapse in patients with Ph + ALL after frontline ponatinib and blinatumomab., PMID:40369607
Mendelian randomization analysis reveals the potential of the IKZF1 gene as a therapeutic target in colorectal cancer., PMID:40394429
The role of IKZF1 rs4132601 and Δ4-7 somatic deletion in acute lymphoblastic leukemia: a bioinformatics and case-control study., PMID:40402344
Mapping Inherited Genetic Variation with Opposite Effects on Autoimmune Disease and Four Cancer Types Identifies Candidate Drug Targets Associated with the Anti-Tumor Immune Response., PMID:40428397
For research use only. Not for human or drug use.
