Catalog No.
DHK10005
Expression system
Mammalian Cells
Species reactivity
Human
Host species
Mouse
Isotype
IgG1
Clonality
Monoclonal
Target
TAG-72
Concentration
4.31 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
TAG-72
Applications
Research Grade Biosimilar
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names
TAG-72, TAG, HMW mucin-like glycoprotein, CA 72-4
Clone ID
CC49
Development and Potent Anti-Tumor Activity of a Fully Humanized Anti-TAG-72-IL-2 Fusion Protein for Therapy of Solid Tumors., PMID:40361381
Targeting TAG-72 in cutaneous T cell lymphoma., PMID:39263154
Antibody engineering to generate anti-tumor-associated glycoprotein 72 mouse recombinant CC49 IgG with improved solubility, purity, and thermal stability., PMID:38145790
Development of an automated chemiluminescent immunoassay for cancer antigen 72-4 and the evaluation of its analytical performance., PMID:36713933
Survival Advantage Following TAG-72 Antigen-Directed Cancer Surgery in Patients With Colorectal Carcinoma: Proposed Mechanisms of Action., PMID:34950576
First clinical study of a pegylated diabody 124I-labeled PEG-AVP0458 in patients with tumor-associated glycoprotein 72 positive cancers., PMID:33052222
Humanized Fluorescent Tumor-associated Glycoprotein-72 Antibody Selectively Labels Colon-cancer Liver Metastases in Orthotopic Mouse Models., PMID:32871754
TAG-72-Targeted α-Radionuclide Therapy of Ovarian Cancer Using 225Ac-Labeled DOTAylated-huCC49 Antibody., PMID:32620701
Improved targeting of an anti-TAG-72 antibody drug conjugate for the treatment of ovarian cancer., PMID:32368864
Humanized Anti-Tumor-Associated Glycoprotein-72 for Submillimeter Near-Infrared Detection of Colon Cancer in Metastatic Mouse Models., PMID:32217350
Preclinical Evaluation of a Novel 18F-Labeled dTCO-Amide Derivative for Bioorthogonal Pretargeted Positron Emission Tomography Imaging., PMID:32175492
Improved stability of a novel fluorine-18 labeled TCO analogue for pretargeted PET imaging., PMID:31707309
The prognostic role of tumor associated glycoprotein 72 (TAG-72) in stage II and III colorectal adenocarcinoma., PMID:30466765
Chemically triggered drug release from an antibody-drug conjugate leads to potent antitumour activity in mice., PMID:29728559
Linker engineering in anti-TAG-72 antibody fragments optimizes biophysical properties, serum half-life, and high-specificity tumor imaging., PMID:29669811
Expression and Targeting of Tumor Markers in Gelfoam® Histoculture: Potential Individualized Assays for Immuno-Oncology., PMID:29572791
Multivalent interactions between streptavidin-based pretargeting fusion proteins and cell receptors impede efficient internalization of biotinylated nanoparticles., PMID:28870833
A 3E8.scFv.Cys-IR800 Conjugate Targeting TAG-72 in an Orthotopic Colorectal Cancer Model., PMID:28643153
Improving theranostics in pancreatic cancer., PMID:28513912
In Vivo Pretargeted Imaging of HER2 and TAG-72 Expression Using the HaloTag Enzyme., PMID:28505463
Pretargeting with bispecific fusion proteins facilitates delivery of nanoparticles to tumor cells with distinct surface antigens., PMID:28363519
Safety, tumor trafficking and immunogenicity of chimeric antigen receptor (CAR)-T cells specific for TAG-72 in colorectal cancer., PMID:28344808
A Fas Ligand (FasL)-Fused Humanized Antibody Against Tumor-Associated Glycoprotein 72 Selectively Exhibits the Cytotoxic Effect Against Oral Cancer Cells with a Low FasL/Fas Ratio., PMID:28292939
Safety and Outcome Measures of First-in-Human Intraperitoneal α Radioimmunotherapy With 212Pb-TCMC-Trastuzumab., PMID:27906723
Development of Rous sarcoma Virus-like Particles Displaying hCC49 scFv for Specific Targeted Drug Delivery to Human Colon Carcinoma Cells., PMID:26047779
Role of tumor-associated glycoprotein-72 in the progression of endometrial adenocarcinoma: a proposed study., PMID:25769704
Extension of the in vivo half-life of endostatin and its improved anti-tumor activities upon fusion to a humanized antibody against tumor-associated glycoprotein 72 in a mouse model of human colorectal carcinoma., PMID:25762629
A model for targeting colon carcinoma cells using single-chain variable fragments anchored on virus-like particles via glycosyl phosphatidylinositol anchor., PMID:24570130
Evaluation of glycodendron and synthetically modified dextran clearing agents for multistep targeting of radioisotopes for molecular imaging and radioimmunotherapy., PMID:24219178
Comparison between two labeled agents in mice using a coinjection-ratio approach in contrast to a conventional group approach., PMID:24210286
Site specific discrete PEGylation of (124)I-labeled mCC49 Fab' fragments improves tumor MicroPET/CT imaging in mice., PMID:24175669
T cells expressing VHH-directed oligoclonal chimeric HER2 antigen receptors: towards tumor-directed oligoclonal T cell therapy., PMID:24076235
New optical method for enhanced detection of colon cancer by capsule endoscopy., PMID:23969635
Quantum dots incorporated magnetic nanoparticles for imaging colon carcinoma cells., PMID:23957878
Synthesis of CdTe quantum dot-conjugated CC49 and their application for in vitro imaging of gastric adenocarcinoma cells., PMID:23800369
A recombinant scFv-FasLext as a targeting cytotoxic agent against human Jurkat-Ras cancer., PMID:23497165
In vitro gastric cancer cell imaging using near-infrared quantum dot-conjugated CC49., PMID:23162639
Development of oligoclonal nanobodies for targeting the tumor-associated glycoprotein 72 antigen., PMID:23015323
Genetically engineered T cells bearing chimeric nanoconstructed receptors harboring TAG-72-specific camelid single domain antibodies as targeting agents., PMID:22902507
Engineering of near IR fluorescent albumin nanoparticles for in vivo detection of colon cancer., PMID:22891637
Predictors of long-term outcome from intraperitoneal radioimmunotherapy for ovarian cancer., PMID:22239432
Oncologic theranostics: recognition of this concept in antigen-directed cancer therapy for colorectal cancer with anti-TAG-72 monoclonal antibodies., PMID:21902525
Antigen-directed cancer surgery for primary colorectal cancer: 15-year survival analysis., PMID:21732140
Polyelectrolyte Nanogels Decorated with Monoclonal Antibody for Targeted Drug Delivery., PMID:21503276
Site-specific conjugation of monodispersed DOTA-PEGn to a thiolated diabody reveals the effect of increasing peg size on kidney clearance and tumor uptake with improved 64-copper PET imaging., PMID:21395337
Biodistribution and dosimetry of In-111/Y-90-HuCC49ΔCh2 (IDEC-159) in patients with metastatic colorectal adenocarcinoma., PMID:21355784
Engagement of the mannose receptor by tumoral mucins activates an immune suppressive phenotype in human tumor-associated macrophages., PMID:21331365
For research use only. Not for human or drug use.
