Catalog No.
DHK06906
Expression system
Mammalian Cells
Species reactivity
Human
Host species
Human
Isotype
IgG1, kappa
Clonality
Monoclonal
Target
V-set domain-containing immunoregulatory receptor, C10orf54, VSIR, VISTA, SISP1, Stress-induced secreted protein-1, Platelet receptor Gi24, V-set immunoregulatory receptor, Sisp-1, V-type immunoglobulin domain-containing suppressor of T-cell activation
Concentration
1.38 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
Q9H7M9
Applications
Research Grade Biosimilar
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names
V-set domain-containing immunoregulatory receptor, C10orf54, VSIR, VISTA, SISP1, Stress-induced secreted protein-1, Platelet receptor Gi24, V-set immunoregulatory receptor, Sisp-1, V-type immunoglobulin domain-containing suppressor of T-cell activation
Clone ID
SG7
Discovery of bifunctional small molecules targeting PD-L1/VISTA with favorable pharmacokinetics for cancer immunotherapy., PMID:40049048
Targeting cell-surface VISTA expression on allospecific naïve T cells promotes tolerance., PMID:39919264
YAP/TEAD4/SP1-induced VISTA expression as a tumor cell-intrinsic mechanism of immunosuppression in colorectal cancer., PMID:39875519
VISTA in hematological malignancies: a review of the literature., PMID:39742253
Small molecule inhibitors targeting PD-L1, CTLA4, VISTA, TIM-3, and LAG3 for cancer immunotherapy (2020-2024)., PMID:39653621
V-domain immunoglobulin suppressor of T-cell activation and programmed death receptor 1 dual checkpoint blockade enhances antitumour immunity and survival in glioblastoma., PMID:39626657
Immune checkpoint expression on tumor-infiltrating lymphocytes (TIL) is dependent on HPV status in oropharyngeal carcinoma (OPSCC) - A single-cell RNA sequencing analysis., PMID:39549431
Immune Checkpoint VISTA Negatively Regulates Microglia Glycolysis and Activation via TRIM28-Mediated Ubiquitination of HK2 in Sepsis-Associated Encephalopathy., PMID:39455538
Multiplexed Spatial Imaging at the Single-Cell Level Reveals Mutually Exclusive Expression of B7 Family Proteins., PMID:39244158
Targeting of immune checkpoint regulator V-domain Ig suppressor of T-cell activation (VISTA) with 89Zr-labelled CI-8993., PMID:39060374
Aberrant expression of B7-H4 and B7-H5 contributes to the development of cutaneous squamous cell carcinoma., PMID:38850312
Repositioning baloxavir marboxil as VISTA agonist that ameliorates experimental asthma., PMID:38340268
PD-1H/VISTA mediates immune evasion in acute myeloid leukemia., PMID:38060328
VISTA blockade alleviates immunosuppression of MDSCs in oral squamous cell carcinoma., PMID:37907049
Imatinib and M351-0056 enhance the function of VISTA and ameliorate the development of SLE via IFN-I and noncanonical NF-κB pathway., PMID:37804401
Enhancement of Radiation Therapy through Blockade of the Immune Checkpoint, V-domain Ig Suppressor of T Cell Activation (VISTA), in Melanoma and Adenocarcinoma Murine Models., PMID:37762046
The immune checkpoint VISTA is associated with prognosis in patients with malignant uveal melanoma., PMID:37662962
Immune-checkpoint protein VISTA in allergic, autoimmune disease and transplant rejection., PMID:37435070
VISTA expression and patient selection for immune-based anticancer therapy., PMID:36891296
Immune checkpoint receptor VISTA on immune cells is associated with expression of T-cell exhaustion marker TOX and worse prognosis in renal cell carcinoma with venous tumor thrombus., PMID:36042047
Distinct immune stimulatory effects of anti-human VISTA antibodies are determined by Fc-receptor interaction., PMID:35967294
Different clinical significance of novel B7 family checkpoints VISTA and HHLA2 in human lung adenocarcinoma., PMID:35187955
Kidney VISTA prevents IFN-γ/IL-9 axis-mediated tubulointerstitial fibrosis after acute glomerular injury., PMID:34752423
VISTA Blockade Aggravates Bone Loss in Experimental Murine Apical Periodontitis., PMID:34691045
Immune related endonucleases and GTPases are not associated with tumor response in patients with advanced non-small cell lung cancer treated with checkpoint inhibitors., PMID:34673351
VISTA Stimulation of VSIG4-Positive Macrophages Strongly Suppresses T Cell Proliferation via Excessive Nitric Oxide Production in Sepsis., PMID:34433706
VISTA facilitates phagocytic clearance of HIV infected CEM-SS T cells., PMID:34401556
High-Affinity Anti-VISTA Antibody Protects against Sepsis by Inhibition of T Lymphocyte Apoptosis and Suppression of the Inflammatory Response., PMID:34366711
VISTA is an activating receptor in human monocytes., PMID:34106206
VISTA and PD-L1 synergistically predict poor prognosis in patients with extranodal natural killer/T-cell lymphoma., PMID:33889438
Structural Basis of VSIG3: The Ligand for VISTA., PMID:33841409
VISTA: A Target to Manage the Innate Cytokine Storm., PMID:33643285
Prognostic significance and therapeutic potential of the immune checkpoint VISTA in pancreatic cancer., PMID:33237432
VISTA Re-programs Macrophage Biology Through the Combined Regulation of Tolerance and Anti-inflammatory Pathways., PMID:33178206
Converging focal radiation and immunotherapy in a preclinical model of triple negative breast cancer: contribution of VISTA blockade., PMID:33150045
An engineered antibody binds a distinct epitope and is a potent inhibitor of murine and human VISTA., PMID:32938950
The prognostic significance of VISTA and CD33-positive myeloid cells in cutaneous melanoma and their relationship with PD-1 expression., PMID:32873829
VISTA deficiency protects from immune complex-mediated glomerulonephritis by inhibiting neutrophil activation., PMID:32586651
Potential Therapeutic Targets of B7 Family in Colorectal Cancer., PMID:32477326
The polymorphism rs975484 in the protein arginine methyltransferase 1 gene modulates expression of immune checkpoint genes in hepatocellular carcinoma., PMID:32245889
The expression and immunoregulation of immune checkpoint molecule VISTA in autoimmune diseases and cancers., PMID:32057701
VISTA is a checkpoint regulator for naïve T cell quiescence and peripheral tolerance., PMID:31949051
VISTA: Coming of age as a multi-lineage immune checkpoint., PMID:31930484
PD-1H (VISTA)-mediated suppression of autoimmunity in systemic and cutaneous lupus erythematosus., PMID:31826980
Acidity changes immunology: a new VISTA pathway., PMID:31822869
VISTA is an acidic pH-selective ligand for PSGL-1., PMID:31645726
Structure and Functional Binding Epitope of V-domain Ig Suppressor of T Cell Activation., PMID:31484064
CA-170 - A Potent Small-Molecule PD-L1 Inhibitor or Not?, PMID:31374878
Inhibition of allogeneic islet graft rejection by VISTA-conjugated liposome., PMID:31272717
Hypoxia-Induced VISTA Promotes the Suppressive Function of Myeloid-Derived Suppressor Cells in the Tumor Microenvironment., PMID:31088847
For research use only. Not for human or drug use.
