Anti-CDK2 Polyclonal Antibody

Catalog No.

PHD64701

Species reactivity

Human, Rat

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human CDK2 (Met1-Leu298).

Tested applications

ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000

Target

CDK2,p33 protein kinase,Cyclin-dependent kinase 2,CDKN2,Cell division protein kinase 2

Purification

Purified by antigen affinity column.

Accession

P24941

Applications

ELISA, IHC, WB

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Transient silencing of hypermutation preserves B cell affinity during clonal bursting., PMID:40108454

Beyond failure of endocrine-based therapies in HR+/HER2 negative advanced breast cancer: What before chemotherapy? A glimpse into the future., PMID:39900320

Targeting refractory diffuse large B cell lymphoma by CAR-WEE1 T-cells: In vitro evaluation., PMID:39820427

A Huluwa phosphorylation switch regulates embryonic axis induction., PMID:39562571

Pim1 is Critical in T-cell-independent B-cell Response and MAPK Activation in B Cells., PMID:39505064

Precision therapeutics and emerging strategies for HR-positive metastatic breast cancer., PMID:39179659

Therapeutic Effects of Arctiin on Alzheimer's Disease-like Model in Rats by Reducing Oxidative Stress, Inflammasomes and Fibrosis., PMID:39136502

Anti-EGFR Antibody-Drug Conjugate Carrying an Inhibitor Targeting CDK Restricts Triple-Negative Breast Cancer Growth., PMID:38772416

Antibody-free time-resolved terbium luminescence assays designed for cyclin-dependent kinase 5 (CDK5)., PMID:38712268

P16-CD8-Ki67 Triple Algorithm for Prediction of CDKN2A Mutations in Patients with Multiple Primary and Familial Melanoma., PMID:38667459

Green tea EGCG inhibits naïve CD4+ T cell division and progression in mice: An integration of network pharmacology, molecular docking and experimental validation., PMID:37441168

Specific phosphorylation of microtubule-associated protein 2c by extracellular signal-regulated kinase reduces interactions at its Pro-rich regions., PMID:35987383

CDK Inhibition Primes for Anti-PD-L1 Treatment in Triple-Negative Breast Cancer Models., PMID:35884422

What protein kinases are crucial for acantholysis and blister formation in pemphigus vulgaris? A systematic review., PMID:35616233

HER2 + breast cancers evade anti-HER2 therapy via a switch in driver pathway., PMID:34795269

Revised International Prognostic Index and genetic alterations are associated with early failure to R-CHOP in patients with diffuse large B-cell lymphoma., PMID:34632572

Mechanism-based therapeutic targets of pemphigus vulgaris: A scoping review of pathogenic molecular pathways., PMID:34435386

Hsa_circ_0000520 overexpression increases CDK2 expression via miR-1296 to facilitate cervical cancer cell proliferation., PMID:34284793

Kinase CDK2 in Mammalian Meiotic Prophase I: Screening for Hetero- and Homomorphic Sex Chromosomes., PMID:33671248

G1 Cell Cycle Arrest and Extrinsic Apoptotic Mechanisms Underlying the Anti-Leukemic Activity of CDK7 Inhibitor BS-181., PMID:33352782

Cyclin E overexpression confers resistance to trastuzumab through noncanonical phosphorylation of SMAD3 in HER2+ breast cancer., PMID:33054513

Expression of p27 and p16 and their clinical significance in gastric cancer., PMID:32880047

Accelerating drug development for neuroblastoma: Summary of the Second Neuroblastoma Drug Development Strategy forum from Innovative Therapies for Children with Cancer and International Society of Paediatric Oncology Europe Neuroblastoma., PMID:32653773

CACYBP Enhances Cytoplasmic Retention of P27Kip1 to Promote Hepatocellular Carcinoma Progression in the Absence of RNF41 Mediated Degradation., PMID:31754404

A novel CDK-2 homolog identified in lamprey, Lampetra japonica, with roles in apoptosis., PMID:31325080

Induction of Melanoma Cell-Selective Apoptosis Using Anti-HER2 Antibody-Conjugated Gold Nanoparticles., PMID:31124333

Disruption of CUL3-mediated ubiquitination causes proximal tubule injury and kidney fibrosis., PMID:30872636

Progesterone impairs Herceptin effect on breast cancer cells., PMID:29434878

Alcoholic hepatitis versus non-alcoholic steatohepatitis: Levels of expression of some proteins involved in tumorigenesis., PMID:29307797

ERpS294 is a biomarker of ligand or mutational ERα activation and a breast cancer target for CDK2 inhibition., PMID:29137354

Cholesterol homeostasis and cell proliferation by mitogenic homologs: insulin, benzo-α-pyrene and UV radiation., PMID:29101605

Inhibition of SHIP2 in CD2AP-deficient podocytes ameliorates reactive oxygen species generation but aggravates apoptosis., PMID:28878342

Whole-blood RNA transcript-based models can predict clinical response in two large independent clinical studies of patients with advanced melanoma treated with the checkpoint inhibitor, tremelimumab., PMID:28807052

High-Content Imaging and RNAi Screens for Investigating Kinase Network Plasticity., PMID:28730478

Expression of YAP/TAZ in Keratocystic Odontogenic Tumors and Its Possible Association with Proliferative Behavior., PMID:28512636

TGFβ engages MEK/ERK to differentially regulate benign and malignant pancreas cell function., PMID:28368414

The natural flavonoid apigenin sensitizes human CD44+ prostate cancer stem cells to cisplatin therapy., PMID:28107698

Sodium fluoride (NaF) causes toxic effects on splenic development in mice., PMID:28002795

Viscolin Inhibits In Vitro Smooth Muscle Cell Proliferation and Migration and Neointimal Hyperplasia In Vivo., PMID:27977759

Cell cycle S phase markers are expressed in cerebral neuron nuclei of cats infected by the Feline Panleukopenia Virus., PMID:27830988

Inhibitory effect of NBL1 on PDGF-BB-induced human PASMC proliferation through blockade of PDGFβ-p38MAPK pathway., PMID:27474499

AMPKα1 deletion in fibroblasts promotes tumorigenesis in athymic nude mice by p52-mediated elevation of erythropoietin and CDK2., PMID:27449088

Cdk2 catalytic activity is essential for meiotic cell division in vivo., PMID:27371320

[Correlation between cyclin-dependent kinase inhibitor p27kip1 and trastuzumab-resistance in gastric cancer]., PMID:27269920

Cytoplasmic Cyclin E and Phospho-Cyclin-Dependent Kinase 2 Are Biomarkers of Aggressive Breast Cancer., PMID:27182644

Critical reanalysis of the methods that discriminate the activity of CDK2 from CDK1., PMID:26986210

Serum translationally controlled tumor protein is involved in rat liver regeneration after hepatectomy., PMID:26969900

Platinum-zoledronate complex blocks gastric cancer cell proliferation by inducing cell cycle arrest and apoptosis., PMID:26891667

Bufalin enhances antitumor effect of paclitaxel on cervical tumorigenesis via inhibiting the integrin α2/β5/FAK signaling pathway., PMID:26758421

Tumoral NKG2D alters cell cycle of acute myeloid leukemic cells and reduces NK cell-mediated immune surveillance., PMID:26740330

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