The structural basis of herpesvirus entry. PMID: 33087881
Epstein Barr Virus: Development of Vaccines and Immune Cell Therapy for EBV-Associated Diseases. PMID: 34691042
A bivalent Epstein-Barr virus vaccine induces neutralizing antibodies that block infection and confer immunity in humanized mice. PMID: 35507671
Immunization with a self-assembling nanoparticle vaccine displaying EBV gH/gL protects humanized mice against lethal viral challenge. PMID: 35705092
gH/gL supercomplexes at early stages of herpesvirus entry. PMID: 26849495
Epstein-Barr virus gH/gL has multiple sites of vulnerability for virus neutralization and fusion inhibition. PMID: 36306784
Ephrin receptor A2 is an epithelial cell receptor for Epstein-Barr virus entry. PMID: 29292383
Immunization with Components of the Viral Fusion Apparatus Elicits Antibodies That Neutralize Epstein-Barr Virus in B Cells and Epithelial Cells. PMID: 30979688
Stuck in the middle: structural insights into the role of the gH/gL heterodimer in herpesvirus entry. PMID: 23107819
A Neutralizing Antibody Targeting gH Provides Potent Protection against EBV Challenge In Vivo. PMID: 35348362
Epstein-Barr Virus gH/gL and Kaposi's Sarcoma-Associated Herpesvirus gH/gL Bind to Different Sites on EphA2 To Trigger Fusion. PMID: 32847853
In silico analysis of antiviral phytochemicals efficacy against Epstein-Barr virus glycoprotein H. PMID: 33438528
Epstein-Barr virus glycoprotein gH/gL antibodies complement IgA-viral capsid antigen for diagnosis of nasopharyngeal carcinoma. PMID: 27093005
Integrins as Herpesvirus Receptors and Mediators of the Host Signalosome. PMID: 27501260
Soluble Epstein-Barr virus glycoproteins gH, gL, and gp42 form a 1:1:1 stable complex that acts like soluble gp42 in B-cell fusion but not in epithelial cell fusion. PMID: 16973550
The Cytoplasmic Tail Domain of Epstein-Barr Virus gH Regulates Membrane Fusion Activity through Altering gH Binding to gp42 and Epithelial Cell Attachment. PMID: 27935841
Structural and Mechanistic Insights into the Tropism of Epstein-Barr Virus. PMID: 27094060
Compatibility of the gH homologues of Epstein-Barr virus and related lymphocryptoviruses. PMID: 17622614
The large groove found in the gH/gL structure is an important functional domain for Epstein-Barr virus fusion. PMID: 23325693
Comparative Mutagenesis of Pseudorabies Virus and Epstein-Barr Virus gH Identifies a Structural Determinant within Domain III of gH Required for Surface Expression and Entry Function. PMID: 26656711
A soluble form of Epstein-Barr virus gH/gL inhibits EBV-induced membrane fusion and does not function in fusion. PMID: 23200314
Crystal structure of the Epstein-Barr virus (EBV) glycoprotein H/glycoprotein L (gH/gL) complex. PMID: 21149717
Epstein-Barr virus gH is essential for penetration of B cells but also plays a role in attachment of virus to epithelial cells. PMID: 10864642
Mapping regions of Epstein-Barr virus (EBV) glycoprotein B (gB) important for fusion function with gH/gL. PMID: 21376360
The KGD motif of Epstein-Barr virus gH/gL is bifunctional, orchestrating infection of B cells and epithelial cells. PMID: 22215569
Human MHC-II with Shared Epitope Motifs Are Optimal Epstein-Barr Virus Glycoprotein 42 Ligands-Relation to Rheumatoid Arthritis. PMID: 29361739
The conserved disulfide bond within domain II of Epstein-Barr virus gH has divergent roles in membrane fusion with epithelial cells and B cells. PMID: 25231307
Molecular basis of EphA2 recognition by gHgL from gammaherpesviruses. PMID: 33235207
Potential entry receptors for human γ-herpesvirus into epithelial cells: A plausible therapeutic target for viral infections. PMID: 34800753
Rabbits immunized with Epstein-Barr virus gH/gL or gB recombinant proteins elicit higher serum virus neutralizing activity than gp350. PMID: 27291087
Mapping the N-terminal residues of Epstein-Barr virus gp42 that bind gH/gL by using fluorescence polarization and cell-based fusion assays. PMID: 20668073
The amino terminus of Epstein-Barr virus glycoprotein gH is important for fusion with epithelial and B cells. PMID: 16160168
The Epstein-Barr virus (EBV) BZLF2 gene product associates with the gH and gL homologs of EBV and carries an epitope critical to infection of B cells but not of epithelial cells. PMID: 7539502
Novel Epstein-Barr virus-like particles incorporating gH/gL-EBNA1 or gB-LMP2 induce high neutralizing antibody titers and EBV-specific T-cell responses in immunized mice. PMID: 27926486
Antibody Generation and Immunogenicity Analysis of EBV gp42 N-Terminal Region. PMID: 34960650
The Murid Herpesvirus-4 gL regulates an entry-associated conformation change in gH. PMID: 18665235
Maternal Epstein-Barr Virus-Specific Antibodies and Risk of Infection in Ugandan Infants. PMID: 33095855
Inhibition of EBV-mediated membrane fusion by anti-gHgL antibodies. PMID: 28939750
Epstein-Barr virus uses different complexes of glycoproteins gH and gL to infect B lymphocytes and epithelial cells. PMID: 9621012
Plxdc family members are novel receptors for the rhesus monkey rhadinovirus (RRV). PMID: 33657166
Mutations of Epstein-Barr virus gH that are differentially able to support fusion with B cells or epithelial cells. PMID: 16103144
Point mutations in EBV gH that abrogate or differentially affect B cell and epithelial cell fusion. PMID: 17307213
Binding-site interactions between Epstein-Barr virus fusion proteins gp42 and gH/gL reveal a peptide that inhibits both epithelial and B-cell membrane fusion. PMID: 17581996
Epstein-Barr virus evasion of CD8(+) and CD4(+) T cell immunity via concerted actions of multiple gene products. PMID: 18977445
High IgG titers against EBV glycoprotein 42 correlate with lower risk of nasopharyngeal carcinoma., PMID:39959976
A gH/gL-encoding replicon vaccine elicits neutralizing antibodies that protect humanized mice against EBV challenge., PMID:38926438
Epstein-Barr virus gp42 antibodies reveal sites of vulnerability for receptor binding and fusion to B cells., PMID:38479361
Urgency and necessity of Epstein-Barr virus prophylactic vaccines., PMID:36494369
Antibody Generation and Immunogenicity Analysis of EBV gp42 N-Terminal Region., PMID:34960650
Potential entry receptors for human γ-herpesvirus into epithelial cells: A plausible therapeutic target for viral infections., PMID:34800753
The structural basis of herpesvirus entry., PMID:33087881
HLA-DPB1 and Epstein-Barr virus gp42 protein jointly contribute to the development of Hodgkin lymphoma., PMID:35117807
Immunization with Components of the Viral Fusion Apparatus Elicits Antibodies That Neutralize Epstein-Barr Virus in B Cells and Epithelial Cells., PMID:30979688
Immunoinformatic and systems biology approaches to predict and validate peptide vaccines against Epstein-Barr virus (EBV)., PMID:30679646
An Antibody Targeting the Fusion Machinery Neutralizes Dual-Tropic Infection and Defines a Site of Vulnerability on Epstein-Barr Virus., PMID:29669253
Human MHC-II with Shared Epitope Motifs Are Optimal Epstein-Barr Virus Glycoprotein 42 Ligands-Relation to Rheumatoid Arthritis., PMID:29361739
Epstein-Barr Virus Fusion with Epithelial Cells Triggered by gB Is Restricted by a gL Glycosylation Site., PMID:28956769
Inhibition of EBV-mediated membrane fusion by anti-gHgL antibodies., PMID:28939750
The Cytoplasmic Tail Domain of Epstein-Barr Virus gH Regulates Membrane Fusion Activity through Altering gH Binding to gp42 and Epithelial Cell Attachment., PMID:27935841
Structural basis for Epstein-Barr virus host cell tropism mediated by gp42 and gHgL entry glycoproteins., PMID:27929061
Structural and Mechanistic Insights into the Tropism of Epstein-Barr Virus., PMID:27094060
Comparative Mutagenesis of Pseudorabies Virus and Epstein-Barr Virus gH Identifies a Structural Determinant within Domain III of gH Required for Surface Expression and Entry Function., PMID:26656711
Scanning Mutagenesis of Human Cytomegalovirus Glycoprotein gH/gL., PMID:26656708
Human Cytomegalovirus gH/gL/gO Promotes the Fusion Step of Entry into All Cell Types, whereas gH/gL/UL128-131 Broadens Virus Tropism through a Distinct Mechanism., PMID:26085146
Membrane anchoring of Epstein-Barr virus gp42 inhibits fusion with B cells even with increased flexibility allowed by engineered spacers., PMID:25564465
[The entry of Epstein-Barr virus into B lymphocytes and epithelial cells during infection]., PMID:25272606
The conserved disulfide bond within domain II of Epstein-Barr virus gH has divergent roles in membrane fusion with epithelial cells and B cells., PMID:25231307
Assembly and architecture of the EBV B cell entry triggering complex., PMID:25144748
The large groove found in the gH/gL structure is an important functional domain for Epstein-Barr virus fusion., PMID:23325693
The KGD motif of Epstein-Barr virus gH/gL is bifunctional, orchestrating infection of B cells and epithelial cells., PMID:22215569
Epstein-Barr virus infection of polarized epithelial cells via the basolateral surface by memory B cell-mediated transfer infection., PMID:21573183
Fusion of epithelial cells by Epstein-Barr virus proteins is triggered by binding of viral glycoproteins gHgL to integrins alphavbeta6 or alphavbeta8., PMID:19920174
Functional analysis of glycoprotein L (gL) from rhesus lymphocryptovirus in Epstein-Barr virus-mediated cell fusion indicates a direct role of gL in gB-induced membrane fusion., PMID:19457993
Cleavage and secretion of Epstein-Barr virus glycoprotein 42 promote membrane fusion with B lymphocytes., PMID:19369343
Structure of Epstein-Barr virus glycoprotein 42 suggests a mechanism for triggering receptor-activated virus entry., PMID:19217393
The BDLF2 protein of Epstein-Barr virus is a type II glycosylated envelope protein whose processing is dependent on coexpression with the BMRF2 protein., PMID:18995876
Compatibility of the gH homologues of Epstein-Barr virus and related lymphocryptoviruses., PMID:17622614
Binding-site interactions between Epstein-Barr virus fusion proteins gp42 and gH/gL reveal a peptide that inhibits both epithelial and B-cell membrane fusion., PMID:17581996
Functional homology of gHs and gLs from EBV-related gamma-herpesviruses for EBV-induced membrane fusion., PMID:17477951
Point mutations in EBV gH that abrogate or differentially affect B cell and epithelial cell fusion., PMID:17307213
Soluble Epstein-Barr virus glycoproteins gH, gL, and gp42 form a 1:1:1 stable complex that acts like soluble gp42 in B-cell fusion but not in epithelial cell fusion., PMID:16973550
The amino terminus of Epstein-Barr virus glycoprotein gH is important for fusion with epithelial and B cells., PMID:16160168
Mutations of Epstein-Barr virus gH that are differentially able to support fusion with B cells or epithelial cells., PMID:16103144
Cell-surface expression of a mutated Epstein-Barr virus glycoprotein B allows fusion independent of other viral proteins., PMID:15583133
Capacity of Epstein-Barr virus to infect monocytes and inhibit their development into dendritic cells is affected by the cell type supporting virus replication., PMID:15448337
Mutational analyses of Epstein-Barr virus glycoprotein 42 reveal functional domains not involved in receptor binding but required for membrane fusion., PMID:15140992
Alternate replication in B cells and epithelial cells switches tropism of Epstein-Barr virus., PMID:12042810
Coreceptor restriction within the HLA-DQ locus for Epstein-Barr virus infection., PMID:10908662
Epstein-Barr virus gH is essential for penetration of B cells but also plays a role in attachment of virus to epithelial cells., PMID:10864642
Epstein-Barr virus entry utilizing HLA-DP or HLA-DQ as a coreceptor., PMID:10666279
Epstein-Barr virus uses different complexes of glycoproteins gH and gL to infect B lymphocytes and epithelial cells., PMID:9621012
Epstein-Barr virus lacking glycoprotein gp42 can bind to B cells but is not able to infect., PMID:9420211
Epstein-Barr virus uses HLA class II as a cofactor for infection of B lymphocytes., PMID:9151859
The Epstein-Barr virus (EBV) BZLF2 gene product associates with the gH and gL homologs of EBV and carries an epitope critical to infection of B cells but not of epithelial cells., PMID:7539502
For research use only. Not for human or drug use.
