Catalog No.
YVV24601
Expression system
E. coli
Species
Lake Victoria marburgvirus (strain Musoke-80) (MARV) (Marburg virus (strain Kenya/Musoke/1980))
Protein length
Met1-Val303
Predicted molecular weight
35.96 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P35260
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Matrix protein VP40, Marburg VP40, mVP40, Membrane-associated protein VP40, VP40
MyosinVb tail inhibits transport of Marburg virus glycoprotein GP to VP40-enriched sites at the plasma membrane., PMID:40174331
Ebola and Marburg viruses IgG detections in small ruminants and dogs from villages within outbreak areas in Gabon., PMID:40043032
From protein to immunology: comprehensive insights into Marburg virus vaccines, mechanism, and application., PMID:40025302
Longitudinal proteome-wide antibody profiling in Marburg virus survivors identifies wing domain immunogen for vaccine design., PMID:39285186
Rational design of self-amplifying virus-like vesicles with Ebola virus glycoprotein as vaccines., PMID:39217415
Marburg virus exploits the Rab11-mediated endocytic pathway in viral-particle production., PMID:39078193
Design of a novel multi-epitope vaccine against Marburg virus using immunoinformatics studies., PMID:38970027
Repurposing of SARS-CoV-2 compounds against Marburg Virus using MD simulation, mm/GBSA, PCA analysis, and free energy landscape., PMID:38450706
Designing a novel and combinatorial multi-antigenic epitope-based vaccine "MarVax" against Marburg virus-a reverse vaccinology and immunoinformatics approach., PMID:38012426
Chaperoning the driver of filovirus egress to a dead end., PMID:36763514
Marburg Virus VP30 Is Required for Transcription Initiation at the Glycoprotein Gene., PMID:35997284
WWOX-Mediated Degradation of AMOTp130 Negatively Affects Egress of Filovirus VP40 Virus-Like Particles., PMID:35107375
Filovirus VP24 Proteins Differentially Regulate RIG-I and MDA5-Dependent Type I and III Interferon Promoter Activation., PMID:35069519
Marburg and Ebola Virus mRNA 3' Untranslated Regions Contain Negative Regulators of Translation That Are Modulated by ADAR1 Editing., PMID:34346762
Lipid-specific oligomerization of the Marburg virus matrix protein VP40 is regulated by two distinct interfaces for virion assembly., PMID:34019871
Compound FC-10696 Inhibits Egress of Marburg Virus., PMID:33846137
Ubiquitin Ligase SMURF2 Interacts with Filovirus VP40 and Promotes Egress of VP40 VLPs., PMID:33673144
Angiomotin Counteracts the Negative Regulatory Effect of Host WWOX on Viral PPxY-Mediated Egress., PMID:33536174
Modified vaccinia Ankara vaccine expressing Marburg virus-like particles protects guinea pigs from lethal Marburg virus infection., PMID:32922962
High-Throughput Screening Assay to Identify Small Molecule Inhibitors of Marburg Virus VP40 Protein., PMID:32870648
Mutation of Hydrophobic Residues in the C-Terminal Domain of the Marburg Virus Matrix Protein VP40 Disrupts Trafficking to the Plasma Membrane., PMID:32344654
Impact of Měnglà Virus Proteins on Human and Bat Innate Immune Pathways., PMID:32295912
Modular mimicry and engagement of the Hippo pathway by Marburg virus VP40: Implications for filovirus biology and budding., PMID:31905227
Analysis of the multifunctionality of Marburg virus VP40., PMID:30394868
A Fluorescently Labeled Marburg Virus Glycoprotein as a New Tool to Study Viral Transport and Assembly., PMID:30165666
Pan-Filovirus Serum Neutralizing Antibodies in a Subset of Congolese Ebolavirus Infection Survivors., PMID:30107445
Marburg virus-like particles by co-expression of glycoprotein and matrix protein in insect cells induces immune responses in mice., PMID:29070075
Intracellular Crosslinking of Filoviral Nucleoproteins with Xintrabodies Restricts Viral Packaging., PMID:29021793
Deep-sequencing of Marburg virus genome during sequential mouse passaging and cell-culture adaptation reveals extensive changes over time., PMID:28611428
Marburg virus-like particles produced in insect cells induce neutralizing antibodies in rhesus macaques., PMID:28402024
Detection of lipid-induced structural changes of the Marburg virus matrix protein VP40 using hydrogen/deuterium exchange-mass spectrometry., PMID:28167534
Chaperone-Mediated Autophagy Protein BAG3 Negatively Regulates Ebola and Marburg VP40-Mediated Egress., PMID:28076420
Novel activities by ebolavirus and marburgvirus interferon antagonists revealed using a standardized in vitro reporter system., PMID:27930961
ITCH E3 Ubiquitin Ligase Interacts with Ebola Virus VP40 To Regulate Budding., PMID:27489272
An active site mutation increases the polymerase activity of the guinea pig-lethal Marburg virus., PMID:27450090
Human Survivors of Disease Outbreaks Caused by Ebola or Marburg Virus Exhibit Cross-Reactive and Long-Lived Antibody Responses., PMID:27335383
Virus-Like Particle Vaccination Protects Nonhuman Primates from Lethal Aerosol Exposure with Marburgvirus (VLP Vaccination Protects Macaques against Aerosol Challenges)., PMID:27070636
Effects of Filovirus Interferon Antagonists on Responses of Human Monocyte-Derived Dendritic Cells to RNA Virus Infection., PMID:26962215
Investigation of the Lipid Binding Properties of the Marburg Virus Matrix Protein VP40., PMID:26719280
Crystal Structure of Marburg Virus VP40 Reveals a Broad, Basic Patch for Matrix Assembly and a Requirement of the N-Terminal Domain for Immunosuppression., PMID:26656687
A Single Amino Acid Change in the Marburg Virus Matrix Protein VP40 Provides a Replicative Advantage in a Species-Specific Manner., PMID:26581998
Lloviu virus VP24 and VP35 proteins function as innate immune antagonists in human and bat cells., PMID:26255028
Amino Acid Residue at Position 79 of Marburg Virus VP40 Confers Interferon Antagonism in Mouse Cells., PMID:25926685
Homologous and heterologous protection of nonhuman primates by Ebola and Sudan virus-like particles., PMID:25793502
Cross-protection conferred by filovirus virus-like particles containing trimeric hybrid glycoprotein., PMID:25514232
Interaction with Tsg101 is necessary for the efficient transport and release of nucleocapsids in marburg virus-infected cells., PMID:25330247
Determination of specific antibody responses to the six species of ebola and Marburg viruses by multiplexed protein microarrays., PMID:25230936
Membrane binding and bending in Ebola VP40 assembly and egress., PMID:24995005
Small-molecule probes targeting the viral PPxY-host Nedd4 interface block egress of a broad range of RNA viruses., PMID:24741084
Sequence variability in viral genome non-coding regions likely contribute to observed differences in viral replication amongst MARV strains., PMID:23510675
For research use only. Not for human or drug use.
