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Anti-CFL1 Polyclonal Antibody

Catalog #:   PHD59301 Specific References (25) DATASHEET
Host species: Rabbit
Isotype: IgG
Applications: ELISA, IHC, WB
Accession: P23528
Overview

Catalog No.

PHD59301

Species reactivity

Human, Mouse, Rat

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human CFL1 (Ser3-Leu161).

Tested applications

ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000

Target

Cofilin,non-muscle isoform,CFL1,p18,18 kDa phosphoprotein,CFL,Cofilin-1

Purification

Purified by antigen affinity column.

Accession

P23528

Applications

ELISA, IHC, WB

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Data Image
  • WESTERN BLOT
    Recombinant Protein lysates were subjected to SDS PAGE followed by western blot with CFL1 antibody (PHD59301) at 1 μg/ml.

    Lane 1: Recombinant protein

    Second Ab: Goat Anti-Rabbit IgG H&L Polyclonal antibody, HRP (PTB96431) at 0.1 μg/mL.

    Predict MW: 20 kDa
    Observed MW: 20 kDa
References

A high affinity Sybody blocks Cofilin-1 binding to F-actin in vitro and in cancer cells., PMID:40064451

Serum anti-CFL1, anti-EZR, and anti-CYPA autoantibody as diagnostic markers in ovarian cancer., PMID:38684875

Complex changes in serum protein levels in COVID-19 convalescents., PMID:38396092

Drug repurposing screens identify compounds that inhibit α-synuclein oligomers' membrane disruption and block antibody interactions., PMID:36937574

The combination of positive anti‑WDR1 antibodies with negative anti‑CFL1 antibodies in serum is a poor prognostic factor for patients with esophageal carcinoma., PMID:36875818

Low anti-CFL1 antibody with high anti-ACTB antibody is a poor prognostic factor in esophageal squamous cell carcinoma., PMID:35780443

Inhibition of Cathepsin B and SAPC Secreted by HIV-Infected Macrophages Reverses Common and Unique Apoptosis Pathways., PMID:34994563

Cofilin1-driven actin dynamics controls migration of thymocytes and is essential for positive selection in the thymus., PMID:31974112

Nogo-A promotes inflammatory heat hyperalgesia by maintaining TRPV-1 function in the rat dorsal root ganglion neuron., PMID:30024789

Multiple reaction monitoring targeted LC-MS analysis of potential cell death marker proteins for increased bioprocess control., PMID:29607450

CD74 interacts with CD44 and enhances tumorigenesis and metastasis via RHOA-mediated cofilin phosphorylation in human breast cancer cells., PMID:27626171

Effect of omega-3 polyunsaturated fatty acids on the cytoskeleton: an open-label intervention study., PMID:25971815

Chemokine receptor 7 promotes tumor migration and invasiveness via the RhoA/ROCK pathway in metastatic squamous cell carcinoma of the head and neck., PMID:25434638

Enhanced cellular radiosensitivity induced by cofilin-1 over-expression is associated with reduced DNA repair capacity., PMID:23362981

B cell receptor-induced Ca2+ mobilization mediates F-actin rearrangements and is indispensable for adhesion and spreading of B lymphocytes., PMID:23362305

Actin depolymerizing factors cofilin1 and destrin are required for ureteric bud branching morphogenesis., PMID:21060807

Regulation of AMPA receptor channels and synaptic plasticity by cofilin phosphatase Slingshot in cortical neurons., PMID:20442266

Decreased cofilin1 expression is important for compaction during early mouse embryo development., PMID:19751773

Ca(2+) influx through P2X receptors induces actin cytoskeleton reorganization by the formation of cofilin rods in neurites., PMID:17993279

The P2Y2 nucleotide receptor requires interaction with alpha v integrins to access and activate G12., PMID:17452627

Palladin regulates cell and extracellular matrix interaction through maintaining normal actin cytoskeleton architecture and stabilizing beta1-integrin., PMID:17115415

Actin-depolymerizing factor and cofilin-1 play overlapping roles in promoting rapid F-actin depolymerization in mammalian nonmuscle cells., PMID:15548599

The three mouse actin-depolymerizing factor/cofilins evolved to fulfill cell-type-specific requirements for actin dynamics., PMID:11809832

A putative plant homolog of the yeast beta-1,3-glucan synthase subunit FKS1 from cotton (Gossypium hirsutum L.) fibers., PMID:11469587

Characterization of human muscle type cofilin (CFL2) in normal and regenerating muscle., PMID:11422377

Datasheet
$ 170
Product specifications
50 μg 170 100 μg 280

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For research use only. Not for human or drug use.

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Anti-CFL1 Polyclonal Antibody [PHD59301]
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