Catalog No.
PHD53701
Species reactivity
Human, Mouse, Rat
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human IGFBP4 (Asp22-Glu258).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
IGF-binding protein 4,IBP-4,Insulin-like growth factor-binding protein 4,IGFBP-4,IGFBP4,IBP4
Purification
Purified by antigen affinity column.
Accession
P22692
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Multiplex Proteomics in the Identification of Potential Biomarkers of Very Severe Sinusoidal Obstruction Syndrome/Veno-Occlusive Disease in Allogeneic Hematopoietic Cell Transplant Patients Treated with Defibrotide., PMID:38330921
Effects of Different Doses of Exercise on Inflammation Markers Among Adolescents With Overweight/Obesity: HEPAFIT Study., PMID:35038337
Cross-sectional study of plasma Axl, ferritin, IGFBP4 and sTNFR2 as biomarkers of disease activity in childhood-onset SLE: A study of the Pediatric Nephrology Research Consortium., PMID:33990158
Serum Cytokine Profiling Identifies Axl as a New Biomarker Candidate for Active Eosinophilic Granulomatosis With Polyangiitis., PMID:33987203
Aberrant pregnancy-associated plasma protein-A expression in breast cancers prognosticates clinical outcomes., PMID:32792532
Novel Insights Into the Effects of Interleukin 6 Antagonism in Non-ST-Segment-Elevation Myocardial Infarction Employing the SOMAscan Proteomics Platform., PMID:32515246
Effects of colostrum instead of formula feeding for the first 2 days postnatum on whole-body energy metabolism and its endocrine control in neonatal calves., PMID:32089303
Metalloproteinase PAPP-A regulation of IGF-1 contributes to polycystic kidney disease pathogenesis., PMID:31990681
Overcoming platinum resistance in ovarian cancer by targeting pregnancy-associated plasma protein-A., PMID:31751381
The IGF system in patients with inflammatory bowel disease treated with prednisolone or infliximab: potential role of the stanniocalcin-2 / PAPP-A / IGFBP-4 axis., PMID:31159802
Glia-Like Cells from Late-Passage Human MSCs Protect Against Ischemic Stroke Through IGFBP-4., PMID:31081524
Functional molecules in mesothelial-to-mesenchymal transition revealed by transcriptome analyses., PMID:29774544
Peptidyl-prolyl cis/trans isomerase Pin1 regulates withaferin A-mediated cell cycle arrest in human breast cancer cells., PMID:29603395
Pregnancy-associated plasma protein-A (PAPP-A) levels in patients with severe allergic asthma are reduced by omalizumab., PMID:29211611
Induction of Regulatory T Cells and Its Regulation with Insulin-like Growth Factor/Insulin-like Growth Factor Binding Protein-4 by Human Mesenchymal Stem Cells., PMID:28724578
Higher IGFBP-1 to IGF-1 serum ratio predicts unfavourable survival in patients with nasopharyngeal carcinoma., PMID:28143425
Characterization of endogenously circulating IGFBP-4 fragments-Novel biomarkers for cardiac risk assessment., PMID:26025773
Increased expression of angiogenic and inflammatory proteins in the vitreous of patients with ischemic central retinal vein occlusion., PMID:25978399
Growth factors and their receptors derived from human amniotic cells in vitro., PMID:25308731
Inhibition of tumor-associated αvβ3 integrin regulates the angiogenic switch by enhancing expression of IGFBP-4 leading to reduced melanoma growth and angiogenesis in vivo., PMID:25249331
Indirect targeting of IGF receptor signaling in vivo by substrate-selective inhibition of PAPP-A proteolytic activity., PMID:24572990
SOX9 directly regulates IGFBP-4 in the intestinal epithelium., PMID:23660500
Development of IGF signaling antibody arrays for the identification of hepatocellular carcinoma biomarkers., PMID:23071652
[Screening the serum protein biomarker of patients with sepsis by cytokine antibody chips]., PMID:21906478
Radiation response and regulation of apoptosis induced by a combination of TRAIL and CHX in cells lacking mitochondrial DNA: a role for NF-κB-STAT3-directed gene expression., PMID:21440540
Discovery and characterization of IGFBP-mediated endocytosis in the human retinal pigment epithelial cell line ARPE-19., PMID:19540231
Acquired resistance to EGFR tyrosine kinase inhibitors in cancer cells is mediated by loss of IGF-binding proteins., PMID:18568074
Inhibition of the proteolytic activity of pregnancy-associated plasma protein-A by targeting substrate exosite binding., PMID:18434323
Discovery and characterization of human antibody inhibitors of pregnancy-associated plasma protein-A., PMID:17516846
Quantification of proteolytically active pregnancy-associated plasma protein-A with an assay based on quenched fluorescence., PMID:17363418
Insulin-like growth factor binding protein-4 gene therapy increases apoptosis by altering Bcl-2 and Bax proteins and decreases angiogenesis in colorectal cancer., PMID:17332927
Expression, content, and localization of insulin-like growth factor I in human achilles tendon., PMID:16987751
Insulin-like growth factor binding protein-4 (IGFBP-4) is a novel anti-angiogenic and anti-tumorigenic mediator secreted by dibutyryl cyclic AMP (dB-cAMP)-differentiated glioblastoma cells., PMID:16586492
Immunohistochemical localization of components of the insulin-like growth factor system in human permanent teeth., PMID:16321360
Low IGF-I in synovial fluid and serum in patients with aseptic prosthesis loosening., PMID:16156457
IGF-I differentially regulates IGF-binding protein expression in primary mammary fibroblasts and epithelial cells., PMID:16002546
Pregnancy-associated plasma protein-A proteolytic activity in rat vertebral cell cultures: stimulation by dexamethasone--a potential mechanism for glucocorticoid regulation of osteoprogenitor proliferation and differentiation., PMID:15754336
Proteolytic degradation of IGF-binding protein (IGFBP)-2 in equine ovarian follicles: involvement of pregnancy-associated plasma protein-A (PAPP-A) and association with dominant but not subordinated follicles., PMID:15350187
Pregnancy-associated plasma protein-a production in rat granulosa cells: stimulation by follicle-stimulating hormone and inhibition by the oocyte-derived bone morphogenetic protein-15., PMID:15087430
Insulin-like growth factor-binding protein-4 inhibits growth of the thymus in transgenic mice., PMID:15072544
Insulin-like growth factor binding protein-4 interacts with centrosomes and microtubules in primary astrocytes., PMID:15062981
Identification of a novel SP3 binding site in the promoter of human IGFBP4 gene: role of SP3 and AP-1 in regulating promoter activity in CaCo2 cells., PMID:14767471
Studies on regulation of IGF (insulin-like growth factor)-binding protein (IGFBP) 4 proteolysis by pregnancy-associated plasma protein-A (PAPP-A) in cells treated with phorbol ester., PMID:14705967
trans-10, cis-12 conjugated linoleic acid reduces insulin-like growth factor-II secretion in HT-29 human colon cancer cells., PMID:14585185
Insulin-like growth factor (IGF)-I and IGF binding proteins-2, -3, -4, -5 in porcine corpora lutea during the estrous cycle; evidence for inhibitory actions of IGFBP-3., PMID:12972375
Regulation of vascular smooth muscle cell responses to insulin-like growth factor (IGF)-I by local IGF-binding proteins., PMID:12917428
Expression of pregnancy-associated plasma protein-A (PAPP-A) during human villous trophoblast differentiation in vitro., PMID:12744930
PTH ameliorates acidosis-induced adverse effects in skeletal growth centers: the PTH-IGF-I axis., PMID:12631114
Role of IGF system of mitogens in the induction of fibroblast proliferation by keloid-derived keratinocytes in vitro., PMID:12620890
Selection of the dominant follicle and insulin-like growth factor (IGF)-binding proteins: evidence that pregnancy-associated plasma protein A contributes to proteolysis of IGF-binding protein 5 in bovine follicular fluid., PMID:12538602
For research use only. Not for human or drug use.
