Catalog No.
FHJ14820
Species reactivity
Human
Host species
Mouse
Isotype
IgG2a, kappa
Clonality
Monoclonal
Conjugation
Unconjugated
Target
V-set domain-containing T-cell activation inhibitor 1, B7h.5, B7 homolog 4, B7-H4, T-cell costimulatory molecule B7x, B7H4, VTCN1, Protein B7S1, Immune costimulatory protein B7-H4
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
Q7Z7D3
Applications
ELISA, FCM
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.09% Sodium azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
7C8
A mini-overview of antibody-drug conjugates in platinum-resistant ovarian cancer: A preclinical and clinical perspective., PMID:39922351
Multiplexed Spatial Imaging at the Single-Cell Level Reveals Mutually Exclusive Expression of B7 Family Proteins., PMID:39244158
Tuning Immune-Cold Tumor by Suppressing USP10/B7-H4 Proteolytic Axis Reinvigorates Therapeutic Efficacy of ADCs., PMID:39206932
B7H4 Role in Solid Cancers: A Review of the Literature., PMID:39061159
Aberrant expression of B7-H4 and B7-H5 contributes to the development of cutaneous squamous cell carcinoma., PMID:38850312
A B7-H4-Targeting Antibody-Drug Conjugate Shows Antitumor Activity in PARPi and Platinum-Resistant Cancers with B7-H4 Expression., PMID:37882675
Discovery and Preclinical Characterization of XMT-1660, an Optimized B7-H4-Targeted Antibody-Drug Conjugate for the Treatment of Cancer., PMID:37294948
B7-H4 is increased in lung adenocarcinoma harboring EGFR-activating mutations and contributes to immunosuppression., PMID:34839353
Clinical Research on the Mechanisms Underlying Immune Checkpoints and Tumor Metastasis., PMID:34367975
Development of a novel anti-B7-H4 antibody enhances anti-tumor immune response of human T cells., PMID:34328096
Establishment of a novel double-monoclonal antibody sandwich enzyme-linked immunosorbent assay (ELISA): tool for human B7-H4 detection in autoimmune diseases., PMID:33961296
Search for Genetic Predictors of Adult Autoimmune Polyendocrine Syndrome in Monozygotic Twins., PMID:33953634
Comparative analysis of drug response and gene profiling of HER2-targeted tyrosine kinase inhibitors., PMID:33473169
Overexpression of B7-H4 is associated with infiltrating immune cells and poor prognosis in metastatic colorectal cancer., PMID:33187907
B7-H4 Inhibits the Development of Primary Sjögren's Syndrome by Regulating Treg Differentiation in NOD/Ltj Mice., PMID:33062721
The anti-B7-H4 checkpoint synergizes trastuzumab treatment to promote phagocytosis and eradicate breast cancer., PMID:32966956
Antibody targeting of B7-H4 enhances the immune response in urothelial carcinoma., PMID:32363111
Identification of the cis‑molecular neighbours of the immune checkpoint protein B7‑H4 in the breast cancer cell‑line SK‑BR‑3 by proteomic proximity labelling., PMID:32319587
B7x-from bench to bedside., PMID:31555486
Immunoglobulin Binding Protein 1 as a Potential Urine Biomarker in Patients with Lupus Nephritis., PMID:31137925
Increased Serum Levels of Soluble B7-H4 in Patients with Systemic Lupus Erythematosus., PMID:30864554
Expression and clinical significance of PD-L1, B7-H3, B7-H4 and TILs in human small cell lung Cancer (SCLC)., PMID:30850021
A T-cell-engaging B7-H4/CD3-bispecific Fab-scFv Antibody Targets Human Breast Cancer., PMID:30737243
Construction, expression and functional analysis of anti-B7-H4- scFv-CH3 recombinant antibody., PMID:30207312
B7-H3 Expression in NSCLC and Its Association with B7-H4, PD-L1 and Tumor-Infiltrating Lymphocytes., PMID:28539467
Molecular Pathways: Evaluating the Potential for B7-H4 as an Immunoregulatory Target., PMID:28325750
Potential targeting of B7-H4 for the treatment of cancer., PMID:28258701
New checkpoints in cancer immunotherapy., PMID:28258699
The third group of the B7-CD28 immune checkpoint family: HHLA2, TMIGD2, B7x, and B7-H3., PMID:28258693
Unstable B7-H4 cell surface expression and T-cell redirection as a means of cancer therapy., PMID:27632942
[Construction of anti-B7-H4-scFv library and screening and identification of anti-B7-H4-scFv]., PMID:27609584
Immune response-associated gene analysis of 1,000 cancer patients using whole-exome sequencing and gene expression profiling-Project HOPE., PMID:27544999
B7-H4 expression indicates poor prognosis of oral squamous cell carcinoma., PMID:27383830
Higher preoperative serum levels of PD-L1 and B7-H4 are associated with invasive and metastatic potential and predictable for poor response to VEGF-targeted therapy and unfavorable prognosis of renal cell carcinoma., PMID:27292320
Expression of B7-H4 and hepatitis B virus X in hepatitis B virus-related hepatocellular carcinoma., PMID:27182163
B7-H4 facilitates proliferation of esophageal squamous cell carcinoma cells through promoting interleukin-6/signal transducer and activator of transcription 3 pathway activation., PMID:27088889
B7-H4(B7x)-Mediated Cross-talk between Glioma-Initiating Cells and Macrophages via the IL6/JAK/STAT3 Pathway Lead to Poor Prognosis in Glioma Patients., PMID:27001312
Isolation and Validation of Anti-B7-H4 scFvs from an Ovarian Cancer scFv Yeast-Display Library., PMID:26060068
B7-H4 expression by nonhematopoietic cells in the tumor microenvironment promotes antitumor immunity., PMID:25527357
[Inhibition of PI3K/AKT signaling pathway promotes the nuclear translocation of B7-H4]., PMID:25374071
B7x/B7-H4 modulates the adaptive immune response and ameliorates renal injury in antibody-mediated nephritis., PMID:25205493
Preparation and characterization of monoclonal antibody against human B7-H4 molecule., PMID:25171007
VISTA is a novel broad-spectrum negative checkpoint regulator for cancer immunotherapy., PMID:24894088
Inhibition of mouse SP2/0 myeloma cell growth by the B7-H4 protein vaccine., PMID:24314141
B7-H4-Ig treatment of normal mice changes lymphocyte homeostasis and increases the potential of regulatory T cells., PMID:23841452
The expression of B7-H1 and B7-H4 co-stimulatory molecules on myeloid and plasmacytoid dendritic cells in pre-eclampsia and normal pregnancy., PMID:23773232
Novel recombinant human b7-h4 antibodies overcome tumoral immune escape to potentiate T-cell antitumor responses., PMID:23722540
B7-H4Ig inhibits mouse and human T-cell function and treats EAE via IL-10/Treg-dependent mechanisms., PMID:23683881
B7-H4.Ig inhibits the development of type 1 diabetes by regulating Th17 cells in NOD mice., PMID:23623902
Coinhibitory molecules in cancer biology and therapy., PMID:23380546
For research use only. Not for human or drug use.
