Catalog No.
RHC17902
Species reactivity
Human
Host species
Mouse
Isotype
IgG1, kappa
Clonality
Monoclonal
Target
Type-II keratin Kb8, CYK8, Keratin-8, KRT8, Keratin, type II cytoskeletal 8, Cytokeratin-8, CK-8, K8, Cytokeratin-18, CYK18, K18, Keratin, type I cytoskeletal 18, KRT18, CK-18, Keratin-18, Cell proliferation-inducing gene 46 protein
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P05787, P05783
Applications
ELISA, FCM, FuncS, IHC
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
SAA1385
Identifying Space-Resolved Proteins of the Murine Thymus, by Combining MALDI Mass Spectrometry Imaging and Proteomics., PMID:40502118
Luminex-based pilot study identifies novel serum autoantibodies associated with disease activity in patients with lupus nephritis., PMID:40500568
Association of Keratin 8 Level in Aqueous Humor With Outcomes of Intravitreal Ranibizumab Treatment for Neovascular Age-Related Macular Degeneration., PMID:35040914
Novel Autoantibodies in Idiopathic Small Fiber Neuropathy., PMID:34761434
The influence of the long-term chemical activation of the nuclear receptor pregnane X receptor (PXR) on liver carcinogenesis in mice., PMID:33398415
Comprehensive analysis of ALK, ROS1 and RET rearrangements in locally advanced rectal cancer., PMID:33168793
The O-Linked N-Acetylglucosamine Containing Epitope H (O-GlcNAcH) is Upregulated in the Trophoblastic and Downregulated in the Fibroblastic Cells in Missed Miscarriage Human Chorionic Villi With Simple Hydropic Degeneration., PMID:32897971
Dimethylarsinic acid (DMA) enhanced lung carcinogenesis via histone H3K9 modification in a transplacental mouse model., PMID:32052077
Kinesin-dependent transport of keratin filaments: a unified mechanism for intermediate filament transport., PMID:29944446
Single lipoaminoglycoside promotes efficient intracellular antibody delivery: A comprehensive insight into the mechanism of action., PMID:28939489
Molecular manipulation of keratin 8/18 intermediate filaments: modulators of FAS-mediated death signaling in human ovarian granulosa tumor cells., PMID:26911253
Absence of keratin 8 or 18 promotes antimitochondrial autoantibody formation in aging male mice., PMID:26399787
Keratin 8 is a novel autoantigen of rheumatoid arthritis., PMID:26277397
[Screening of citrullinated proteins in ten tumor cell lines]., PMID:25975782
Sensitivity and specificity of in situ proximity ligation for protein interaction analysis in a model of steatohepatitis with Mallory-Denk bodies., PMID:24798445
Investigating citrullinated proteins in tumour cell lines., PMID:24099319
Keratin 8 is required for the maintenance of architectural structure in thymus epithelium., PMID:24086449
A conserved rod domain phosphotyrosine that is targeted by the phosphatase PTP1B promotes keratin 8 protein insolubility and filament organization., PMID:24003221
[Clinicopathologic features of papillary tumors of the pineal region]., PMID:23769439
The feasibility of sentinel lymph node biopsy for gastric cancer: the experience from Serbia., PMID:23613402
Clinical and histopathological features and immunoreactivity of human choroidal and ciliary melanomas as prognostic factors for metastasis and death., PMID:21847577
Cytoskeletal keratin glycosylation protects epithelial tissue from injury., PMID:20729838
Keratin 18 provides resistance to Fas-mediated liver failure in mice., PMID:19397691
Proteomic analysis of tumor necrosis factor-alpha resistant human breast cancer cells reveals a MEK5/Erk5-mediated epithelial-mesenchymal transition phenotype., PMID:19087274
Detection of disseminated tumor cells in bone marrow of gastric cancer using magnetic activated cell sorting and fluorescent activated cell sorting., PMID:19032456
A sensitive three-step protocol for fluorescence-based Western blot detection., PMID:18400233
Human renal cells from the thick ascending limb and early distal tubule: characterization of primary isolated and cultured cells by reverse transcription polymerase chain reaction., PMID:18331438
Bispecific and human disease-related anti-keratin rabbit monoclonal antibodies., PMID:16343483
Keratins as susceptibility genes for end-stage liver disease., PMID:16143128
Keratin 8 phosphorylation by protein kinase C delta regulates shear stress-mediated disassembly of keratin intermediate filaments in alveolar epithelial cells., PMID:15972820
Identification of trichoplein, a novel keratin filament-binding protein., PMID:15731013
p62 is involved in the mechanism of Mallory body formation., PMID:15507232
Cytokeratin 5/6 in normal human breast: lack of evidence for a stem cell phenotype., PMID:15376255
Keratin 8 and 18 hyperphosphorylation is a marker of progression of human liver disease., PMID:15368451
[Immunomorphological characteristics of the infiltrative growth in well differentiated thyroid carcinoma]., PMID:15338719
Morphological and immunohistochemical analysis of ductal plate malformation: correlation with fetal liver., PMID:15330804
Keratin 8/18 breakdown and reorganization during apoptosis., PMID:15194421
Human keratin 8 mutations that disturb filament assembly observed in inflammatory bowel disease patients., PMID:15090596
Conformational changes in the rod domain of human keratin 8 following heterotypic association with keratin 18 and its implication for filament stability., PMID:14756564
Keratin-8 null mice have different gallbladder and liver susceptibility to lithogenic diet-induced injury., PMID:14576356
Keratin mutation in transgenic mice predisposes to Fas but not TNF-induced apoptosis and massive liver injury., PMID:12717381
Formation of Mallory body-like inclusions and cell death induced by deregulated expression of keratin 18., PMID:12388748
Simple epithelium keratins 8 and 18 provide resistance to Fas-mediated apoptosis. The protection occurs through a receptor-targeting modulation., PMID:11514590
Sequence of events in the assembly of Mallory body components in mouse liver: clues to the pathogenesis and significance of Mallory body formation., PMID:11434612
Keratin 8 mutations in patients with cryptogenic liver disease., PMID:11372009
For research use only. Not for human or drug use.
