Multi-lineage transcriptional and cell communication signatures define pathways in individuals at-risk for developing rheumatoid arthritis that initiate and perpetuate disease., PMID:40235495
Pre-B-cell leukemia transcription factor 1 contributes to liver fibrosis by enabling IL-7 signaling in HSC., PMID:40080840
Multi-lineage transcriptional and cell communication signatures define pathways in individuals at-risk for developing rheumatoid arthritis that initiate and perpetuate disease., PMID:39974976
Another Notch in the Belt of Rheumatoid Arthritis., PMID:38961731
Perivascular NOTCH3+ Stem Cells Drive Meningioma Tumorigenesis and Resistance to Radiotherapy., PMID:38742767
Impaired retinal oxygen metabolism and perfusion are accompanied by plasma protein and lipid alterations in recovered COVID-19 patients., PMID:38600099
Synovial Tissue Insights into Heterogeneity of Rheumatoid Arthritis., PMID:38157158
Notch ligands are biomarkers of anti-TNF response in RA patients., PMID:37796367
Nestin and Notch3 collaboratively regulate angiogenesis, collagen production, and endothelial-mesenchymal transition in lung endothelial cells., PMID:37735673
NOTCH3 drives meningioma tumorigenesis and resistance to radiotherapy., PMID:37503127
Preferential rabbit antibody responses to C-termini of NOTCH3 peptide immunogens., PMID:37280231
Inhibition of PCSK9 Improves the Development of Pulmonary Arterial Hypertension Via Down-Regulating Notch3 Expression., PMID:37256417
Inflammatory Optic Neuropathy as a Presenting Feature of Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy., PMID:37064940
Concentration of non-myocyte proteins in arterial media of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy., PMID:36753487
A midposition NOTCH3 truncation in inherited cerebral small vessel disease may affect the protein interactome., PMID:36470429
Akt1-dependent expression of angiopoietin 1 and 2 in vascular smooth muscle cells leads to vascular stabilization., PMID:35931736
Detection of Vascular Notch3 Deposits in Unfixed Frozen Skin Biopsy Sample in CADASIL., PMID:35775048
Notch3 expression in capillary pericytes predicts worse graft outcome in human renal grafts with antibody-mediated rejection., PMID:35611804
JAGGED-NOTCH3 signaling in vascular remodeling in pulmonary arterial hypertension., PMID:35507674
Notch-Signaling Deregulation Induces Myeloid-Derived Suppressor Cells in T-Cell Acute Lymphoblastic Leukemia., PMID:35444651
Hydrolysis of a second Asp-Pro site at the N-terminus of NOTCH3 in inherited vascular dementia., PMID:34446744
The Role of Notch3 Signaling in Cancer Stemness and Chemoresistance: Molecular Mechanisms and Targeting Strategies., PMID:34195229
NOTCH3-targeted antibody drug conjugates regress tumors by inducing apoptosis in receptor cells and through transendocytosis into ligand cells., PMID:34095881
Electrophilic and Drug-Induced Stimulation of NOTCH3 N-terminal Fragment Oligomerization in Cerebrovascular Pathology., PMID:33939102
Calcium channel α2δ1 subunit is a functional marker and therapeutic target for tumor-initiating cells in non-small cell lung cancer., PMID:33707423
The Skeleton of Lateral Meningocele Syndrome., PMID:33519922
AKT-dependent NOTCH3 activation drives tumor progression in a model of mesenchymal colorectal cancer., PMID:32749453
Tetraspanin18 regulates angiogenesis through VEGFR2 and Notch pathways., PMID:32694189
The potential danger of blocking CGRP for treating migraine in CADASIL patients., PMID:32660269
Novel dot-blot assay for detection of vascular Notch3 aggregates in patients with CADASIL., PMID:32470649
Transcriptomics analysis of pericytes from retinas of diabetic animals reveals novel genes and molecular pathways relevant to blood-retinal barrier alterations in diabetic retinopathy., PMID:32376470
NOTCH3 T6746C and TP53 P72R Polymorphisms Are Associated with the Susceptibility to Diffuse Cutaneous Systemic Sclerosis., PMID:32185220
Thiol-mediated and catecholamine-enhanced multimerization of a cerebrovascular disease enriched fragment of NOTCH3., PMID:32119934
NOTCH3 is non-enzymatically fragmented in inherited cerebral small-vessel disease., PMID:31901894
Precision medicine for human cancers with Notch signaling dysregulation (Review)., PMID:31894255
Loss of the serine protease HTRA1 impairs smooth muscle cells maturation., PMID:31796853
Therapeutic targeting of Notch signaling and immune checkpoint blockade in a spontaneous, genetically heterogeneous mouse model of T-cell acute lymphoblastic leukemia., PMID:31399482
A randomized phase II trial of nab-paclitaxel and gemcitabine with tarextumab or placebo in patients with untreated metastatic pancreatic cancer., PMID:31347292
An antibody to Notch3 reverses the skeletal phenotype of lateral meningocele syndrome in male mice., PMID:31188489
A phase I, dose-escalation study of PF-06650808, an anti-Notch3 antibody-drug conjugate, in patients with breast cancer and other advanced solid tumors., PMID:30887250
Serum biomarker panels for the diagnosis of gastric cancer., PMID:30873760
A phase 1 dose escalation and expansion study of Tarextumab (OMP-59R5) in patients with solid tumors., PMID:30591982
Expression of Notch 3 and Jagged 1 Is Associated With Merkel Cell Polyomavirus Status and Prognosis in Merkel Cell Carcinoma., PMID:30591475
The soluble ligand Y box-1 activates Notch3 receptor by binding to epidermal growth factor like repeats 20-23., PMID:30321499
Notch3ECD immunotherapy improves cerebrovascular responses in CADASIL mice., PMID:30014602
NOTCH3 contributes to rhinovirus-induced goblet cell hyperplasia in COPD airway epithelial cells., PMID:29991510
Stem Cell Factor in Combination with Granulocyte Colony-Stimulating Factor reduces Cerebral Capillary Thrombosis in a Mouse Model of CADASIL., PMID:29871518
Notch3 protein expression in skin fibroblasts from CADASIL patients., PMID:29801872
Advances in antibody therapeutics targeting small-cell lung cancer., PMID:29790694
Tumor-Infiltrating Lymphocytes in Patients Receiving Trastuzumab/Pertuzumab-Based Chemotherapy: A TRYPHAENA Substudy., PMID:29788230
For research use only. Not for human or drug use.
