Catalog No.
RHG53501
Expression system
Mammalian Cells
Species reactivity
Human
Host species
Alpaca
Isotype
VHH-8His-Cys-tag
Clonality
Monoclonal
Target
Disintegrin and metalloproteinase domain-containing protein 9, Meltrin-gamma, ADAM9, MDC9, MLTNG, ADAM 9, Metalloprotease/disintegrin/cysteine-rich protein 9, Cellular disintegrin-related protein, KIAA0021, MCMP, Myeloma cell metalloproteinase
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Purified by Nickel column.
Accession
Q13443
Applications
ELISA
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
SAA1216
ADAM Proteases in Cancer: Biological Roles, Therapeutic Challenges, and Emerging Opportunities., PMID:40427200
An Antibody of the Secreted Isoform of Disintegrin and Metalloprotease 9 (sADAM9) Inhibits Epithelial-Mesenchymal Transition and Migration of Prostate Cancer Cell Lines., PMID:38928352
Preclinical Evaluation of IMGC936, a Next-Generation Maytansinoid-based Antibody-drug Conjugate Targeting ADAM9-expressing Tumors., PMID:35511740
Long Non-coding RNA RUNDC3A-AS1 Promotes Lung Metastasis of Thyroid Cancer via Targeting the miR-182-5p/ADAM9., PMID:34046406
Gingival Crevicular Fluid Zinc- and Aspartyl-Binding Protease Profile of Individuals with Moderate/Severe Atopic Dermatitis., PMID:33255937
Tetraspanin CD9 interacts with α-secretase to enhance its oncogenic function in pancreatic cancer., PMID:33042435
Fisetin Suppresses the Proliferation and Metastasis of Renal Cell Carcinoma through Upregulation of MEK/ERK-Targeting CTSS and ADAM9., PMID:31438640
Meprin β induces activities of A disintegrin and metalloproteinases 9, 10, and 17 by specific prodomain cleavage., PMID:31381863
Licochalcone A inhibits the invasive potential of human glioma cells by targeting the MEK/ERK and ADAM9 signaling pathways., PMID:30465574
Fisetin suppresses malignant proliferation in human oral squamous cell carcinoma through inhibition of Met/Src signaling pathways., PMID:29312520
Overexpression of ADAM9 in oral squamous cell carcinoma., PMID:29285199
ADAM9 is over-expressed in human ovarian clear cell carcinomas and suppresses cisplatin-induced cell death., PMID:29247567
ADAM9 expression promotes an aggressive lung adenocarcinoma phenotype., PMID:28675123
Areca nut components stimulate ADAM17, IL-1α, PGE2 and 8-isoprostane production in oral keratinocyte: role of reactive oxygen species, EGF and JAK signaling., PMID:26919242
The Protective Roles of IL-6 Trans-Signaling Regulated by ADAM9 on the Liver in Carbon Tetrachloride-Induced Liver Injury in Mice., PMID:26044069
Fisetin suppresses ADAM9 expression and inhibits invasion of glioma cancer cells through increased phosphorylation of ERK1/2., PMID:25527158
The effect of disintegrin-metalloproteinase ADAM9 in gastric cancer progression., PMID:25344581
Proteomics analysis of cancer exosomes using a novel modified aptamer-based array (SOMAscan™) platform., PMID:24505114
A murine model for retinopathy of prematurity identifies endothelial cell proliferation as a potential mechanism for plus disease., PMID:23833070
High expression of the "A Disintegrin And Metalloprotease" 19 (ADAM19), a sheddase for TNF-α in the mucosa of patients with inflammatory bowel diseases., PMID:23429442
Lung cancer-derived galectin-1 enhances tumorigenic potentiation of tumor-associated dendritic cells by expressing heparin-binding EGF-like growth factor., PMID:22291012
Quantitative and dynamic expression profile of premature and active forms of the regional ADAM proteins during chicken brain development., PMID:21786032
Secretome signature of invasive glioblastoma multiforme., PMID:21574646
ADAM10 is the physiologically relevant, constitutive alpha-secretase of the amyloid precursor protein in primary neurons., PMID:20676056
Cell migration in response to the amino-terminal fragment of urokinase requires epidermal growth factor receptor activation through an ADAM-mediated mechanism., PMID:19394555
Human parainfluenza virus type 2 (HPIV2) induced host ADAM8 expression in human salivary adenocarcinoma cell line (HSY) during cell fusion., PMID:19284887
Expression of ADAMs ("a disintegrin and metalloprotease") in the human lung., PMID:19255780
MMSET deregulation affects cell cycle progression and adhesion regulons in t(4;14) myeloma plasma cells., PMID:19059936
UV-induced EGFR signal transactivation is dependent on proligand shedding by activated metalloproteases in skin cancer cell lines., PMID:19003995
Angiotensin II and epidermal growth factor receptor cross-talk mediated by a disintegrin and metalloprotease accelerates tumor cell proliferation of hepatocellular carcinoma cell lines., PMID:18452483
Role of ADAM-9 disintegrin-cysteine-rich domains in human keratinocyte migration., PMID:17704059
ADAM-9 (MDC-9/meltrin-gamma), a member of the a disintegrin and metalloproteinase family, regulates myeloma-cell-induced interleukin-6 production in osteoblasts by direct interaction with the alpha(v)beta5 integrin., PMID:16373656
Gene expression analysis of pancreatic cell lines reveals genes overexpressed in pancreatic cancer., PMID:15983444
The disintegrin-metalloproteinases ADAM9, ADAM12, and ADAM15 are upregulated in gastric cancer., PMID:15586220
Increased expression of ADAM family members in human breast cancer and breast cancer cell lines., PMID:15565459
The disintegrin domain of ADAM9: a ligand for multiple beta1 renal integrins., PMID:15361064
Overexpression of ADAM9 in non-small cell lung cancer correlates with brain metastasis., PMID:15205330
Identification of novel proteins associated with hepatocellular carcinomas using protein microarrays., PMID:14517841
Transmembrane collagen XVII, an epithelial adhesion protein, is shed from the cell surface by ADAMs., PMID:12356719
Involvement of ADAM9 in multinucleated giant cell formation of blood monocytes., PMID:11831872
MDC-9 (ADAM-9/Meltrin gamma) functions as an adhesion molecule by binding the alpha(v)beta(5) integrin., PMID:11162558
Antibody from mice immunized with DNA encoding the carboxyl-disintegrin and cysteine-rich domain (JD9) of the haemorrhagic metalloprotease, Jararhagin, inhibits the main lethal component of viper venom., PMID:10931154
Meltrin gamma(ADAM-9) mediates cellular adhesion through alpha(6)beta(1 )integrin, leading to a marked induction of fibroblast cell motility., PMID:10825303
Identification, cellular distribution and potential function of the metalloprotease-disintegrin MDC9 in the kidney., PMID:10752518
For research use only. Not for human or drug use.
