Catalog No.
RHC21004
Expression system
Mammalian Cells
Species reactivity
Human
Host species
Alpaca
Isotype
VHH-8His-Cys-tag
Clonality
Monoclonal
Target
Meconium antigen 100, CEACAM5, CEA, CD66e, Carcinoembryonic antigen-related cell adhesion molecule 5, Carcinoembryonic antigen
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Purified by Nickel column.
Accession
P06731
Applications
ELISA, FCM, SPR
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
SAA1298
Nanobody-Directed CEA-targeting CAR T Cells Eliminate Gastrointestinal Cancer Xenografts., PMID:40439687
Expression-Dependent Tumor Pretargeting via Engineered Avidity., PMID:39704255
Camelid-derived Tcell engagers harnessing human γδ T cells as promising antitumor immunotherapeutic agents., PMID:38804118
A novel human single-domain antibody-drug conjugate targeting CEACAM5 exhibits potent in vitro and in vivo antitumor activity., PMID:38030799
Development of a highly sensitive immunoassay based on pentameric nanobodies for carcinoembryonic antigen detection., PMID:37827654
Immuno-PET of colorectal cancer with a CEA-targeted [68 Ga]Ga-nanobody: from bench to bedside., PMID:37382662
Optimized silk fibroin nanoparticle functionalization with anti-CEA nanobody enhancing active targeting of colorectal cancer cells., PMID:37321227
Albumin binding improves nanobody pharmacokinetics for dual-modality PET/NIRF imaging of CEACAM5 in colorectal cancer models., PMID:37191678
Near-Infrared Fluorescence Imaging of Pancreatic Cancer Using a Fluorescently Labelled Anti-CEA Nanobody Probe: A Preclinical Study., PMID:37189366
Identification of a CEACAM5 targeted nanobody for positron emission tomography imaging and near-infrared fluorescence imaging of colorectal cancer., PMID:36914753
NIR-II fluorescence imaging-guided colorectal cancer surgery targeting CEACAM5 by a nanobody., PMID:36801616
Correlated STORM-homoFRET imaging reveals highly heterogeneous membrane receptor structures., PMID:36063991
Reprogramming Synthetic Cells for Targeted Cancer Therapy., PMID:35255684
Rapid tumor-labeling kinetics with a site-specific near-infrared anti-CEA nanobody in a patient-derived orthotopic xenograft mouse model of colon cancer., PMID:34309885
Tumor-specific near-infrared nanobody probe rapidly labels tumors in an orthotopic mouse model of pancreatic cancer., PMID:32370916
Development of a highly thermostable immunoassay based on a nanobody-alkaline phosphatase fusion protein for carcinoembryonic antigen detection., PMID:32030492
Carcinoembryonic Antigen (CEA)-Specific 4-1BB-Costimulation Induced by CEA-Targeted 4-1BB-Agonistic Trimerbodies., PMID:31417564
An efficient constitutive expression system for Anti-CEACAM5 nanobody production in the yeast Pichia pastoris., PMID:30414968
A novel multifunctional anti-CEA-IL15 molecule displays potent antitumor activities., PMID:30214153
Site-specific PEGylation of an anti-CEA/CD3 bispecific antibody improves its antitumor efficacy., PMID:29881272
Single- and two-photon imaging of human micrometastases and disseminated tumour cells with conjugates of nanobodies and quantum dots., PMID:29545609
Improving biosensing activity to carcinoembryonic antigen with orientated single domain antibodies., PMID:29423452
A Novel Affinity Tag, ABTAG, and Its Application to the Affinity Screening of Single-Domain Antibodies Selected by Phage Display., PMID:29163485
Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) promotes EGF receptor signaling of oral squamous cell carcinoma metastasis via the complex N-glycosylation., PMID:28892050
A nanobody targeting carcinoembryonic antigen as a promising molecular probe for non-small cell lung cancer., PMID:28586008
Single domain antibody-based bispecific antibody induces potent specific anti-tumor activity., PMID:27645568
Intramolecular trimerization, a novel strategy for making multispecific antibodies with controlled orientation of the antigen binding domains., PMID:27345490
A novel bispecific antibody, S-Fab, induces potent cancer cell killing., PMID:26448579
Detection of carcinoembryonic antigen using single-domain or full-size antibodies stained with quantum dot conjugates., PMID:25766579
Construction of a pIX-modified Adenovirus Vector Able to Effectively Bind to Nanoantibodies for Targeting., PMID:25093116
Multiphoton imaging of tumor biomarkers with conjugates of single-domain antibodies and quantum dots., PMID:24941465
Nanobody: the "magic bullet" for molecular imaging?, PMID:24578722
Single-domain antibody-based and linker-free bispecific antibodies targeting FcγRIII induce potent antitumor activity without recruiting regulatory T cells., PMID:23757164
Single domain antibody against carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) inhibits proliferation, migration, invasion and angiogenesis of pancreatic cancer cells., PMID:22918079
Oriented conjugates of single-domain antibodies and quantum dots: toward a new generation of ultrasmall diagnostic nanoprobes., PMID:21839049
Single-domain antibody bioconjugated near-IR quantum dots for targeted cellular imaging of pancreatic cancer., PMID:21780366
Isolation of functional single domain antibody by whole cell immunization: implications for cancer treatment., PMID:21741385
Strong and oriented immobilization of single domain antibodies from crude bacterial lysates for high-throughput compatible cost-effective antibody array generation., PMID:20859568
In vitro analysis and in vivo tumor targeting of a humanized, grafted nanobody in mice using pinhole SPECT/micro-CT., PMID:20554727
COMBODY: one-domain antibody multimer with improved avidity., PMID:20212511
Llama single-domain antibodies directed against nonconventional epitopes of tumor-associated carcinoembryonic antigen absent from nonspecific cross-reacting antigen., PMID:19531051
ES1, a new lung carcinoma antibody--an immunohistochemical study., PMID:17064298
A pentavalent single-domain antibody approach to tumor antigen discovery and the development of novel proteomics reagents., PMID:15312770
Efficient cancer therapy with a nanobody-based conjugate., PMID:15087403
For research use only. Not for human or drug use.
