Catalog No.
RHC09603
Expression system
Mammalian Cells
Species reactivity
Human
Host species
Alpaca
Isotype
VHH-8His-Cys-tag
Clonality
Monoclonal
Target
p185erbB2, HER2, NGL, Tyrosine kinase-type cell surface receptor HER2, NEU, MLN 19, Proto-oncogene Neu, MLN19, ERBB2, Proto-oncogene c-ErbB-2, CD340, Receptor tyrosine-protein kinase erbB-2, Metastatic lymph node gene 19 protein
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Purified by Nickel column.
Accession
P04626
Applications
FCM, SPR
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
SAA1170
Q-TWiST Analysis of Sacituzumab Govitecan vs. Chemotherapy in Previously Treated Patients with HR+/HER2- Metastatic Breast Cancer., PMID:40136373
The generation of a novel HER2-targeting nano PE25 immunotoxin with superior anti-tumor activity and high productivity., PMID:40086588
Her-2 nanobody modified cisplatin nanoparticles for precise chemotherapy of colon cancer., PMID:39976420
A HER2 Specific Nanobody-Drug Conjugate: Site-Selective Bioconjugation and In Vitro Evaluation in Breast Cancer Models., PMID:39860260
Radiolabeled HER2-targeted molecular probes in breast cancer imaging: current knowledge and future prospective., PMID:39751821
Nanobodies' duo facilitates ultrasensitive serum HER-2/neu immunoassays via enhanced avidity interactions., PMID:39643321
Functional evaluation of circulating anti-cancer antibodies with a 3D tumor cell growth inhibition assay., PMID:39515883
Bacterial Living Therapeutics with Engineered Protein Secretion Circuits to Eliminate Breast Cancer Cells., PMID:39367855
Imaging and Monitoring HER2 Expression in Tumors during HER2 Antibody-Drug Conjugate Therapy Utilizing a Radiolabeled Site-Specific Single-Domain Antibody Probe: 68Ga-NODAGA-SNA004-GSC., PMID:39077778
Dual-Targeting of the HER2 Cancer Receptor with an Antibody-Directed Enzyme and a Nanobody-Guided MMAE Prodrug Scaffold., PMID:38945824
Comparative study of optical fiber immunosensors based on traditional antibody or nanobody for detecting HER2., PMID:38810383
Detection of HER2 expression using 99mTc-NM-02 nanobody in patients with breast cancer: a non-randomized, non-blinded clinical trial., PMID:38459598
Chimeric nanobody-decorated liposomes by self-assembly., PMID:38374413
Human Epidermal Growth Factor Receptor 2/Human Epidermal Growth Factor Receptor 3 PET Imaging: Challenges and Opportunities., PMID:37339919
Evaluation of an 131I-labeled HER2-specific single domain antibody fragment for the radiopharmaceutical therapy of HER2-expressing cancers., PMID:35194100
Generation of a nanobody against HER2 tyrosine kinase using phage display library screening for HER2-positive breast cancer therapy development., PMID:34908139
Review: Radionuclide Molecular Imaging Targeting HER2 in Breast Cancer with a Focus on Molecular Probes into Clinical Trials and Small Peptides., PMID:34770887
Anti-HER2 VHH Targeted Fluorescent Liposome as Bimodal Nanoparticle for Drug Delivery and Optical Imaging., PMID:34365930
Development of a 99mTc-Labeled Single-Domain Antibody for SPECT/CT Assessment of HER2 Expression in Breast Cancer., PMID:34328338
Moderating hypoxia and promoting immunogenic photodynamic therapy by HER-2 nanobody conjugate nanoparticles for ovarian cancer treatment., PMID:34319255
Biochemistry, structure, and cellular internalization of a four nanobody-bearing Fc dimer., PMID:34117809
An anti-HER2 nanobody binds to its antigen HER2 via two independent paratopes., PMID:33848543
Immunogenicity Risk Profile of Nanobodies., PMID:33767701
Site-Specific and Residualizing Linker for 18F Labeling with Enhanced Renal Clearance: Application to an Anti-HER2 Single-Domain Antibody Fragment., PMID:33637584
Phase I Trial of 131I-GMIB-Anti-HER2-VHH1, a New Promising Candidate for HER2-Targeted Radionuclide Therapy in Breast Cancer Patients., PMID:33277400
Modular Conjugation of a Potent Anti-HER2 Immunotoxin Using Coassociating Peptides., PMID:32996763
Disparities between Antibody Occupancy, Orientation, and Cytotoxicity in Immunotherapy., PMID:32274876
HER2-specific immunotoxins constructed based on single-domain antibodies and the improved toxin PE24X7., PMID:31836485
A consensus protocol for the in silico optimisation of antibody fragments., PMID:31690899
VHH characterization.Recombinant VHHs: Production, characterization and affinity., PMID:31676284
Labeling of Anti-HER2 Nanobodies with Astatine-211: Optimization and the Effect of Different Coupling Reagents on Their in Vivo Behavior., PMID:31268724
Expression of Human VH Single Domains as Fc Fusions in Mammalian Cells., PMID:30912019
Cancer Immunotherapy with T Cells Carrying Bispecific Receptors That Mimic Antibodies., PMID:30842091
Selective Cytotoxicity to HER2 Positive Breast Cancer Cells by Saporin-Loaded Nanobody-Targeted Polymeric Nanoparticles in Combination with Photochemical Internalization., PMID:30817164
Polyethyleneimine-polyethylene glycol copolymer targeted by anti-HER2 nanobody for specific delivery of transcriptionally targeted tBid containing construct., PMID:30810413
Isolation and characterization of camelid single-domain antibodies against HER2., PMID:30518413
Evaluation of cellular and transcriptional targeting of breast cancer stem cells via anti-HER2 nanobody conjugated PAMAM dendrimers., PMID:30246563
The chimeric TAC receptor co-opts the T cell receptor yielding robust anti-tumor activity without toxicity., PMID:30076299
Generation of Potent Anti-HER1/2 Immunotoxins by Protein Ligation Using Split Inteins., PMID:29920062
Liposomal nanoparticle armed with bivalent bispecific single-domain antibodies, novel weapon in HER2 positive cancerous cell lines targeting., PMID:29549861
Single- and two-photon imaging of human micrometastases and disseminated tumour cells with conjugates of nanobodies and quantum dots., PMID:29545609
Evaluation of an Anti-HER2 Nanobody Labeled with 225Ac for Targeted α-Particle Therapy of Cancer., PMID:29502411
Binding affinity prediction of nanobody-protein complexes by scoring of molecular dynamics trajectories., PMID:29328338
A Bispecific Antibody Based on Pertuzumab Fab Has Potent Antitumor Activity., PMID:29232309
Engineered cross-reacting nanobodies simplify comparative oncology between humans and dogs., PMID:29047203
131I-labeled Anti-HER2 Camelid sdAb as a Theranostic Tool in Cancer Treatment., PMID:28751451
Optimization of an anti-HER2 nanobody expression using the Taguchi method., PMID:28636463
A novel immuno-gold labeling protocol for nanobody-based detection of HER2 in breast cancer cells using immuno-electron microscopy., PMID:28552722
Limiting the protein corona: A successful strategy for in vivo active targeting of anti-HER2 nanobody-functionalized nanostars., PMID:28152380
The effect of superparamagnetic iron oxide nanoparticles surface engineering on relaxivity of magnetoliposome., PMID:27307214
For research use only. Not for human or drug use.
