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Anti-Human CD4 Nanobody (SAA1296)

Catalog #:   RHB95902 Specific References (49) DATASHEET
Host species: Alpaca
Isotype: VHH-8His-Cys-tag
Applications: ELISA, FCM, SPR
Expression system: Mammalian Cells
Overview

Catalog No.

RHB95902

Expression system

Mammalian Cells

Species reactivity

Human

Host species

Alpaca

Isotype

VHH-8His-Cys-tag

Clonality

Monoclonal

Target

T-cell surface antigen T4/Leu-3, T-cell surface glycoprotein CD4, CD4

Concentration

1.07 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Purified by Nickel column.

Accession

P01730

Applications

ELISA, FCM, SPR

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Clone ID

SAA1296

Data Image
  • SDS-PAGE
    SDS PAGE for Human CD4 Nanobody
References

Indium-111-Labeled Single-Domain Antibody for In Vivo CXCR4 Imaging Using Single-Photon Emission Computed Tomography., PMID:40067691

Focal Molography Allows for Affinity and Concentration Measurements of Proteins in Complex Matrices with High Accuracy., PMID:39996969

PET imaging of HIV-1 envelope protein gp120 using 18F-labeled nanobodies., PMID:39917021

Targeted degradation of the HPV oncoprotein E6 reduces tumor burden in cervical cancer., PMID:39464070

Highly potent and broadly neutralizing anti-CD4 trimeric nanobodies inhibit HIV-1 infection by inducing CD4 conformational alteration., PMID:39138183

Ultrapotent Broadly Neutralizing Human-llama Bispecific Antibodies against HIV-1., PMID:38704686

Novel bispecific nanobody mitigates experimental intestinal inflammation in mice by targeting TNF-α and IL-23p19 bioactivities., PMID:38533646

Methods for studying P2X4 receptor ion channels in immune cells., PMID:38311008

Microbiota-dependent activation of CD4+ T cells induces CTLA-4 blockade-associated colitis via Fcγ receptors., PMID:38175892

Neutrophil-Mediated Tumor-Targeting Delivery System of Oncolytic Bacteria Combined with ICB for Melanoma Lung Metastasis Therapy., PMID:37565362

Nanobody-mediated complement activation to kill HIV-infected cells., PMID:36799046

Bispecific antibody CAP256.J3LS targets V2-apex and CD4-binding sites with high breadth and potency., PMID:36729903

Structural basis for llama nanobody recognition and neutralization of HIV-1 at the CD4-binding site., PMID:35413243

Combination therapy with Nab-paclitaxel and the interleukin-15 fused with anti-human serum albumin nanobody as a synergistic treatment for colorectal cancer., PMID:35019820

Single-Domain Antibodies for Targeting, Detection, and In Vivo Imaging of Human CD4+ Cells., PMID:34956237

Improved targeting of human CD4+ T cells by nanobody-modified AAV2 gene therapy vectors., PMID:34928979

Cell membrane-anchored anti-HIV single-chain antibodies and bifunctional inhibitors targeting the gp41 fusion protein: new strategies for HIV gene therapy., PMID:34821542

Selective inhibition of IL-6 trans-signaling by a miniaturized, optimized chimeric soluble gp130 inhibits TH17 cell expansion., PMID:34404751

Therapeutic depletion of CCR8+ tumor-infiltrating regulatory T cells elicits antitumor immunity and synergizes with anti-PD-1 therapy., PMID:33589525

Generation of HIV-resistant cells with a single-domain antibody: implications for HIV-1 gene therapy., PMID:33462383

Anti-NKG2D single domain-based antibodies for the modulation of anti-tumor immune response., PMID:33457075

Labeling and tracking of immune cells in ex vivo human skin., PMID:33349704

The Potential of Nanobody-Targeted Photodynamic Therapy to Trigger Immune Responses., PMID:32326519

Super Potent Bispecific Llama VHH Antibodies Neutralize HIV via a Combination of gp41 and gp120 Epitopes., PMID:31544844

Domain swapping of complementarity-determining region in nanobodies produced by Pichia pastoris., PMID:31309388

The Antigenic Topology of Norovirus as Defined by B and T Cell Epitope Mapping: Implications for Universal Vaccines and Therapeutics., PMID:31083353

Peptide barcoding for establishment of new types of genotype-phenotype linkages., PMID:31013333

Novel fusion cells derived from tumor cells expressing the heterologous α-galactose epitope and dendritic cells effectively target cancer., PMID:30661833

In Vivo Blockade of Murine ARTC2.2 During Cell Preparation Preserves the Vitality and Function of Liver Tissue-Resident Memory T Cells., PMID:30038627

Nanobody-Antigen Conjugates Elicit HPV-Specific Antitumor Immune Responses., PMID:29792298

A defucosylated bispecific multivalent molecule exhibits broad HIV-1-neutralizing activity and enhanced antibody-dependent cellular cytotoxicity against reactivated HIV-1 latently infected cells., PMID:29762173

Intracellular immunization against HIV infection with an intracellular antibody that mimics HIV integrase binding to the cellular LEDGF protein., PMID:29203900

Selection of nanobodies with broad neutralizing potential against primary HIV-1 strains using soluble subtype C gp140 envelope trimers., PMID:28827559

Generation of Immunity against Pathogens via Single-Domain Antibody-Antigen Constructs., PMID:27821668

The Tax-Inducible Actin-Bundling Protein Fascin Is Crucial for Release and Cell-to-Cell Transmission of Human T-Cell Leukemia Virus Type 1 (HTLV-1)., PMID:27776189

The Glycosylphosphatidylinositol-Anchored Variable Region of Llama Heavy Chain-Only Antibody JM4 Efficiently Blocks both Cell-Free and T Cell-T Cell Transmission of Human Immunodeficiency Virus Type 1., PMID:27654286

Expression of Human Immunodeficiency Virus Type 1 Neutralizing Antibody Fragments Using Human Vaginal Lactobacillus., PMID:26950606

The transduction pattern of IL-12-encoding lentiviral vectors shapes the immunological outcome., PMID:26377033

CD4 binding site broadly neutralizing antibody selection of HIV-1 escape mutants., PMID:25762593

Neutralisation of HIV-1 cell-cell spread by human and llama antibodies., PMID:25700025

Rational design and characterization of the novel, broad and potent bispecific HIV-1 neutralizing antibody iMabm36., PMID:24853313

Specificities of human CD4+ T cell responses to an inactivated flavivirus vaccine and infection: correlation with structure and epitope prediction., PMID:24789782

Structural basis for the inhibition of HIV-1 Nef by a high-affinity binding single-domain antibody., PMID:24620746

Immunogenicity of targeted lentivectors., PMID:24519916

Exceptionally potent and broadly cross-reactive, bispecific multivalent HIV-1 inhibitors based on single human CD4 and antibody domains., PMID:24198429

Heavy chain-only IgG2b llama antibody effects near-pan HIV-1 neutralization by recognizing a CD4-induced epitope that includes elements of coreceptor- and CD4-binding sites., PMID:23843638

Straightforward selection of broadly neutralizing single-domain antibodies targeting the conserved CD4 and coreceptor binding sites of HIV-1 gp120., PMID:23152508

Single-domain antibody-SH3 fusions for efficient neutralization of HIV-1 Nef functions., PMID:22345475

Inhibition of the Nef regulatory protein of HIV-1 by a single-domain antibody., PMID:21292773

Datasheet
$ 372
Product specifications
100 μg 372 1 mg 1860

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For research use only. Not for human or drug use.

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Anti-Human CD4 Nanobody (SAA1296) [RHB95902]
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