Catalog No.
RHE72401
Species reactivity
Human
Host species
Mouse
Isotype
IgG2a, kappa
Clonality
Monoclonal
Target
hSCCE, Stratum corneum chymotryptic enzyme, PRSS6, Kallikrein-7, Serine protease 6, hK7, KLK7, SCCE
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P49862
Applications
Blocking, ELISA
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
SAA0869
Blocking of IL-4/IL-13 Signalling With Dupilumab Results in Restoration of Serum and Cutaneous Abnormalities in Netherton Syndrome., PMID:40344324
KLK7 expression in human tumors: a tissue microarray study on 13,447 tumors., PMID:38961454
Recombinant scFv-Fc Anti-kallikrein 7 Antibody-Loaded Thermosensitive Hydrogels Against Skin Desquamation Disorders., PMID:38886921
Αnti-KLK5/KLK7 Antibody-based Strategies for the Treatment of Epidermal Diseases., PMID:37987118
Overcoming Soluble Target Interference in Measurement of Total Bispecific Therapeutic Antibody Concentrations., PMID:37594571
Mini-PBPK-Based Population Model and Covariate Analysis to Assess the Complex Pharmacokinetics and Pharmacodynamics of RO7449135, an Anti-KLK5/KLK7 Bispecific Antibody in Cynomolgus Monkeys., PMID:37353723
Dual antibody inhibition of KLK5 and KLK7 for Netherton syndrome and atopic dermatitis., PMID:36516271
Anti-inflammatory effects of amarogentin on 2,4-dinitrochlorobenzene-induced atopic dermatitis-like mice and in HaCat cells., PMID:36131559
Therapeutic effects of quinine in a mouse model of atopic dermatitis., PMID:34240224
Validation of the Production of Antibodies in Different Formats in the HEK 293 Transient Gene Expression System., PMID:33301112
Generation of recombinant antibodies against human tissue kallikrein 7 to treat skin diseases., PMID:33096161
Drug promiscuity: Exploring the polypharmacology potential of 1, 3, 6-trisubstituted 1, 4-diazepane-7-ones as an inhibitor of the 'god father' of immune checkpoint., PMID:31146119
Kallikrein-related peptidases represent attractive therapeutic targets for ovarian cancer., PMID:30114962
SCCA2 is a reliable biomarker for evaluating pediatric atopic dermatitis., PMID:29421276
Evidence of an abnormal epithelial barrier in active, untreated and corticosteroid-treated eosinophilic esophagitis., PMID:28712126
Episodic binge ethanol exposure impairs murine macrophage infiltration and delays wound closure by promoting defects in early innate immune responses., PMID:24689549
Caspase-14 protocols., PMID:24567096
Transgenic kallikrein 5 mice reproduce major cutaneous and systemic hallmarks of Netherton syndrome., PMID:24534191
Keratinocyte-specific mesotrypsin contributes to the desquamation process via kallikrein activation and LEKTI degradation., PMID:24390132
Thymic stromal lymphopoietin expression is increased in the horny layer of patients with atopic dermatitis., PMID:23379440
Tickling stimulation causes the up-regulation of the kallikrein family in the submandibular gland of the rat., PMID:22982067
Kallikrein-related peptidase-7 regulates caspase-14 maturation during keratinocyte terminal differentiation by generating an intermediate form., PMID:22825846
Kallikrein-related peptidase 7 promotes multicellular aggregation via the alpha(5)beta(1) integrin pathway and paclitaxel chemoresistance in serous epithelial ovarian carcinoma., PMID:20332224
Binding of alpha2ML1 to the low density lipoprotein receptor-related protein 1 (LRP1) reveals a new role for LRP1 in the human epidermis., PMID:18648652
Human tissue kallikrein 7, a novel biomarker for advanced ovarian carcinoma using a novel in situ quantitative method of protein expression., PMID:18325919
Expression of kallikrein-related peptidases (KRP/hK5, 7, 6, 8) in subtypes of human lung carcinoma., PMID:18182244
Analysis of SPINK 5, KLK 7 and FLG genotypes in a French atopic dermatitis cohort., PMID:17989887
Activation of proteinase-activated receptor-2 by human kallikrein-related peptidases., PMID:17625593
[Cloning and expression of the gene of chymotrypsin-like protease of human kallikrein-7 in Escherichia coli and isolation of recombinant protein]., PMID:17598454
LEKTI fragments specifically inhibit KLK5, KLK7, and KLK14 and control desquamation through a pH-dependent interaction., PMID:17596512
Human tissue kallikrein expression in the stratum corneum and serum of atopic dermatitis patients., PMID:17518992
Unfavorable prognostic value of human kallikrein 7 quantified by ELISA in ovarian cancer cytosols., PMID:16916986
An anti-pso p27 monoclonal antibody reacts with skin and peripheral blood leukocytes from Japanese psoriatic patients and shows cross-reactivity with SCCA2b., PMID:15592934
Degradation of corneodesmosome proteins by two serine proteases of the kallikrein family, SCTE/KLK5/hK5 and SCCE/KLK7/hK7., PMID:15140227
Expression of stratum corneum chymotryptic enzyme in ichthyoses and squamoproliferative processes., PMID:12834483
Stratum corneum tryptic enzyme in normal epidermis: a missing link in the desquamation process?, PMID:10620116
Stratum corneum chymotryptic enzyme in psoriasis., PMID:10335915
In situ evidence that the population of Langerhans cells in normal human epidermis may be heterogeneous., PMID:9205500
Formation of active IL-1 beta from pro-IL-1 beta catalyzed by stratum corneum chymotryptic enzyme in vitro., PMID:9188871
Association between expression of stratum corneum chymotryptic enzyme and pathological keratinization in human oral mucosa., PMID:8800294
Evidence that stratum corneum chymotryptic enzyme is transported to the stratum corneum extracellular space via lamellar bodies., PMID:7537777
Immunolocalization of stratum corneum chymotryptic enzyme in human skin and oral epithelium with monoclonal antibodies: evidence of a proteinase specifically expressed in keratinizing squamous epithelia., PMID:7510318
Expression of stratum corneum chymotryptic enzyme in reconstructed human epidermis and its suppression by retinoic acid., PMID:8105613
For research use only. Not for human or drug use.
