Human CD55 Expression and C1 Inhibition Partially Protect Gene-Edited Pig Red Blood Cells From Human Complement-Mediated Hemolysis In Vitro., PMID:40492338
Single-cell transcriptomic profiling reveals dysregulation of B-cell subset function in patients with chronic hepatitis B., PMID:40489024
Evidence for Complement Activation in Preeclampsia Placenta and Its Presence in Circulation., PMID:40388260
Complement dysregulation at lymphatics., PMID:40300720
Mechanism and regulation of the complement activity in kidney xenotransplantation., PMID:40233672
Minimally invasive retrieval and characterisation of tenosynovial tissue in rheumatoid arthritis: a novel approach to study at-risk, active, and remission stages., PMID:40148202
Claudin-2 enhances human antibody-mediated complement-dependent cytotoxicity of porcine endothelial cells by modulating antibody binding and complement activation., PMID:40040710
Complement Activation and Hemolysis in Non-Human Primates Following Transfusion of Genetically Modified Pig Red Blood Cells., PMID:39933991
Complement regulators as novel targets for anti-cancer therapy: A comprehensive review., PMID:39826189
Exosome-Mediated Lectin Pathway and Resistin-MIF-AA Metabolism Axis Drive Immune Dysfunction in Immune Thrombocytopenia., PMID:39792656
EBV-induced upregulation of CD55 reduces the efficacy of cetuximab treatment in nasopharyngeal carcinoma., PMID:39695702
An evaluation of pozelimab for the treatment of CHAPLE disease., PMID:39657032
Generation and characterization of genetically modified pigs with GGTA1/β4GalNT2/CMAH knockout and human CD55/CD47 expression for xenotransfusion studies., PMID:39622959
SARS-CoV-2 hijacks host CD55, CD59 and factor H to impair antibody-dependent complement-mediated lysis., PMID:39435487
Complement biosensors identify a classical pathway stimulus in complement-mediated thrombotic microangiopathy., PMID:39357054
Population pharmacokinetic analyses of pozelimab in patients with CD55-deficient protein-losing enteropathy (CHAPLE disease)., PMID:39349796
Navigating the Complement Pathway to Optimize PNH Treatment with Pegcetacoplan and Other Currently Approved Complement Inhibitors., PMID:39273426
Iscalimab Combined With Transient Tesidolumab Prolongs Survival in Pig-to-Rhesus Monkey Renal Xenografts., PMID:39185772
Pozelimab for CHAPLE disease: results from in-trial interviews and clinical outcome assessments., PMID:39118150
Protein-losing enteropathy as a new phenotype in atypical hemolytic uremic syndrome caused by CD46 gene mutation., PMID:39097532
Intestinal mRNA expression profiles associated with mucosal healing in ustekinumab-treated Crohn's disease patients: bioinformatics analysis and prospective cohort validation., PMID:38926732
Prolonged xenokidney graft survival in sensitized NHP recipients by expression of multiple human transgenes in a triple knockout pig., PMID:38865482
Complement Biosensors Identify a Classical Pathway Stimulus in Complement-Mediated Hemolytic Uremic Syndrome., PMID:38854038
Structure and function of therapeutic antibodies approved by the US FDA in 2023., PMID:38617189
CD14 facilitates perinatal human cytomegalovirus infection in biliary epithelial cells via CD55., PMID:38601478
Pozelimab, a human monoclonal immunoglobulin for the treatment of CHAPLE disease., PMID:38598858
A 21-bp deletion in the complement regulator CD55 promotor region is associated with multifocal motor neuropathy and its disease course., PMID:38528725
The complement regulator CD55 modulates TLR9 signaling and supports survival in marginal zone B cells., PMID:38496511
Triple-fusion protein (TriFu): A potent, targeted, enzyme-like inhibitor of all three complement activation pathways., PMID:38401844
Evaluating the efficacy and safety of pozelimab in patients with CD55 deficiency with hyperactivation of complement, angiopathic thrombosis, and protein-losing enteropathy disease: an open-label phase 2 and 3 study., PMID:38278170
Interosseous tendon inflammation in the hands of patients with clinically suspect arthralgia: analysis of MRI data from a prospective cohort study., PMID:38251551
The complement cascade in lung injury and disease., PMID:38178176
FLAER as a standalone reagent for paroxysmal nocturnal hemoglobinuria: Do we need to reconsider the guidelines for testing?, PMID:38069562
Dynamic encounters with red blood cells trigger splenic marginal zone B cell retention and function., PMID:38049580
Initial investigation on the feasibility of porcine red blood cells from genetically modified pigs as an alternative to human red blood cells for transfusion., PMID:38035112
CD55 Deficiency With Budd-Chiari Syndrome Treated by Liver Transplantation and Eculizumab., PMID:38018238
Effective clearance of rituximab-resistant tumor cells by breaking the mirror-symmetry of immunoglobulin G and simultaneous binding to CD55 and CD20., PMID:37880350
Complement-membrane regulatory proteins are absent from the nodes of Ranvier in the peripheral nervous system., PMID:37875972
Pozelimab: First Approval., PMID:37856038
MAP-2:CD55 chimeric construct effectively modulates complement activation., PMID:37823685
Single-cell RNA sequencing identifies distinct transcriptomic signatures between PMA/ionomycin- and αCD3/αCD28-activated primary human T cells., PMID:37704208
Metalloporphyrins Reduce Proteinuria in Podocyte Immune Injury: The Role of Metal and Porphyrin Moieties., PMID:37628958
Comprehensive cell surface protein profiling of human mesenchymal stromal cells from peritoneal dialysis effluent and comparison with those from human bone marrow and adipose tissue., PMID:37603218
Ravulizumab Can Effectively Treat Ischemic Enteritis Caused by Paroxysmal Nocturnal Hemoglobinuria., PMID:37558427
Single-cell protein expression profiling resolves circulating and resident memory T cell diversity across tissues and infection contexts., PMID:37392736
Prostate cancer cell-platelet bidirectional signaling promotes calcium mobilization, invasion and apoptotic resistance via distinct receptor-ligand pairs., PMID:36806315
Milestones on the path to clinical pig organ xenotransplantation., PMID:36775767
Generation of novel oncolytic vaccinia virus with improved intravenous efficacy through protection against complement-mediated lysis and evasion of neutralization by vaccinia virus-specific antibodies., PMID:36717184
Inhibition of complement activation by CD55 overexpression in human induced pluripotent stem cell derived kidney organoids., PMID:36713440
Daratumumab induces cell-mediated cytotoxicity of primary effusion lymphoma and is active against refractory disease., PMID:36632565
For research use only. Not for human or drug use.
