Catalog No.
PHD11901
Species reactivity
Human
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human CD46 (Cys35-Asp325).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
Trophoblast leukocyte common antigen,CD46,TLX,MCP,Membrane cofactor protein,MIC10
Purification
Purified by antigen affinity column.
Accession
P15529
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Evidence for Complement Activation in Preeclampsia Placenta and Its Presence in Circulation., PMID:40388260
The multiverse of CD46 and oncologic interactions., PMID:40309774
Complementing Anticancer Therapy: Antibody-Drug Conjugates Targeting CD46 as Prostate Cancer Treatment., PMID:40262077
Mechanism and regulation of the complement activity in kidney xenotransplantation., PMID:40233672
Targeting the tumour cell surface in advanced prostate cancer., PMID:40169837
Phase I, First-in-Human Study of FOR46 (FG-3246), an Immune-Modulating Antibody-Drug Conjugate Targeting CD46, in Patients With Metastatic Castration-Resistant Prostate Cancer., PMID:40138611
Atypical presentation of H1N1-induced thrombotic microangiopathy with CD46 gene mutation
., PMID:40115863
Claudin-2 enhances human antibody-mediated complement-dependent cytotoxicity of porcine endothelial cells by modulating antibody binding and complement activation., PMID:40040710
The generation and evaluation of TKO/hCD55/hTM/hEPCR gene-modified pigs for clinical organ xenotransplantation., PMID:39902050
Complement-Mediated Hemolytic Uremic Syndrome Due to MCP/CD46 Mutation: A Case Report., PMID:39871416
Complement regulators as novel targets for anti-cancer therapy: A comprehensive review., PMID:39826189
Citrullinated IGF2BP1 promotes rheumatoid synovial aggression via increasing the mRNA stability of SEMA3D., PMID:39809921
Antibody‑drug conjugates in prostate cancer: Emerging strategies to enhance therapeutic index and current clinical landscape (Review)., PMID:39670293
A humanized neutralizing antibody protects against human adenovirus type 7 infection in humanized desmoglein-2 and CD46 double-receptor transgenic mice., PMID:39548554
The outer membrane protein, OMP71, of Riemerella anatipestifer, mediates adhesion and virulence by binding to CD46 in ducks., PMID:39407352
Unveiling the impact of Leptospira TolC efflux protein on host tissue adherence, complement evasion, and diagnostic potential., PMID:39392312
Complement biosensors identify a classical pathway stimulus in complement-mediated thrombotic microangiopathy., PMID:39357054
The intricate allostery in factor VIIa: triggering the trigger., PMID:39332529
Development of betabodies: The next generation of phosphatidylserine targeting agents., PMID:39159812
Protein-losing enteropathy as a new phenotype in atypical hemolytic uremic syndrome caused by CD46 gene mutation., PMID:39097532
Proximity Ligation Assay for the Analysis of Iron-Mediated Protein-Protein Interactions in the Nucleus., PMID:39008248
Feasibility study of ADCs targeting TROP-2, HER2, and CD46 in Ductal Adenocarcinoma and Intraductal Carcinoma of the prostate., PMID:38990246
Prolonged xenokidney graft survival in sensitized NHP recipients by expression of multiple human transgenes in a triple knockout pig., PMID:38865482
Complement Biosensors Identify a Classical Pathway Stimulus in Complement-Mediated Hemolytic Uremic Syndrome., PMID:38854038
Anti-pig antibodies in swine veterinarian serum: Implications for clinical xenotransplantation., PMID:38853364
Dual topology of equine arteritis virus GP3 protein and the role of arginine motif RXR in GP3 ER retention., PMID:38850896
Complement regulatory protein CD46 promotes bladder cancer metastasis through activation of MMP9., PMID:38847230
Adolescence-onset atypical hemolytic uremic syndrome: is it different from infant-onset?, PMID:38704765
A 21-bp deletion in the complement regulator CD55 promotor region is associated with multifocal motor neuropathy and its disease course., PMID:38528725
Development of CD46 targeted alpha theranostics in prostate cancer using 134Ce/225Ac-Macropa-PEG4-YS5., PMID:38389832
CD46 and CD59 inhibitors enhance complement-dependent cytotoxicity of anti-CD38 monoclonal antibodies daratumumab and isatuximab in multiple myeloma and other B-cell malignancy cells., PMID:38361357
The complement cascade in lung injury and disease., PMID:38178176
Genetics and measles, mumps and rubella vaccine response in childhood and adolescence-A systematic review., PMID:38157324
CD46-Targeted Theranostics for PET and 225Ac-Radiopharmaceutical Therapy of Multiple Myeloma., PMID:38109209
CD46-ADC Reduces the Engraftment of Multiple Myeloma Patient-Derived Xenografts., PMID:38001595
Eculizumab Versus Ravulizumab for the Treatment of Atypical Hemolytic Uremic Syndrome: A Systematic Review., PMID:37905269
Complement-membrane regulatory proteins are absent from the nodes of Ranvier in the peripheral nervous system., PMID:37875972
Atypical hemolytic uremic syndrome: genetically-based insights into pathogenesis through an analysis of the complement regulator CD46., PMID:39949759
Exploring urinary extracellular vesicles for organ transplant monitoring: A comprehensive study for detection of allograft dysfunction using immune-specific markers., PMID:37633321
Comprehensive cell surface protein profiling of human mesenchymal stromal cells from peritoneal dialysis effluent and comparison with those from human bone marrow and adipose tissue., PMID:37603218
The association between CD46 expression in B cells and the pathogenesis of airway allergy., PMID:37579982
Preclinical Development in Radiopharmaceutical Therapy for Prostate Cancer., PMID:37468417
Membrane Cholesterol Inhibits Progesterone-Mediated Sperm Function through the Possible Involvement of ABHD2., PMID:37298205
Polymorphisms within Autophagy-Related Genes as Susceptibility Biomarkers for Multiple Myeloma: A Meta-Analysis of Three Large Cohorts and Functional Characterization., PMID:37239846
HDAd6/35++ - A new helper-dependent adenovirus vector platform for in vivo transduction of hematopoietic stem cells., PMID:37081854
Treatment of Prostate Cancer with CD46-targeted 225Ac Alpha Particle Radioimmunotherapy., PMID:36917693
CD46 targeted 212Pb alpha particle radioimmunotherapy for prostate cancer treatment., PMID:36906664
Detection of immunoreactive proteins of Escherichia coli, Streptococcus uberis, and Streptococcus agalactiae isolated from cows with diagnosed mastitis., PMID:36844415
Treatment of Human Pancreatic Cancers Following Local and Systemic Administration of Oncolytic Adenovirus Serotype 35., PMID:36697099
Variants in complement genes are uncommon in patients with anti-factor H autoantibody-associated atypical hemolytic uremic syndrome., PMID:36622444
For research use only. Not for human or drug use.
