Catalog No.
PHD11601
Species reactivity
Human
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human AREG (Ser101-Lys187).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
AREG,CRDGF,SDGF,Colorectum cell-derived growth factor,AREGB,Amphiregulin,AR
Purification
Purified by antigen affinity column.
Accession
P15514
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Development and validation of a multiple myeloma diagnostic model based on systemic lupus erythematosus-associated genes and identification of specific genes., PMID:40382732
Hepatic stellate cell-specific Kcnma1 deletion mitigates metabolic dysfunction-associated steatotic liver disease progression via upregulating Amphiregulin secretion., PMID:40348016
Amphiregulin Mediates Epithelial Cell-Eosinophil Interactions and Amplifies Inflammation in Chronic Rhinosinusitis With Nasal Polyps., PMID:40317745
LPS-induced extracellular AREG triggers macrophage pyroptosis through the EGFR/TLR4 signaling pathway., PMID:40292295
EGFR-mediated local invasiveness and response to Cetuximab in head and neck cancer., PMID:40121428
Maternal supplementation with α-tocopherol inhibits the development of offspring food allergy, H1R signaling and ultimately anaphylaxis early in life., PMID:40073242
Neo-adjuvant FOLFOX with and without panitumumab for patients with KRAS-wt locally advanced colon cancer: results following an extended biomarker panel on the FOxTROT trial embedded phase II population., PMID:39805350
Protective effect of TCR-mediated MAIT cell activation during experimental autoimmune encephalomyelitis., PMID:39468055
Amivantamab efficacy in wild-type EGFR NSCLC tumors correlates with levels of ligand expression., PMID:39242834
Sustained amphiregulin expression in intermediate alveolar stem cells drives progressive fibrosis., PMID:39096904
Effects of N361 Glycosylation on Epidermal Growth Factor Receptor Biological Function., PMID:39071333
Stress-induced Rab11a-exosomes induce amphiregulin-mediated cetuximab resistance in colorectal cancer., PMID:38887984
Enhanced amphiregulin exposure promotes modulation of the high grade serous ovarian cancer tumor immune microenvironment., PMID:38831884
Granzyme K- and amphiregulin-expressing cytotoxic T cells and activated extrafollicular B cells are potential drivers of IgG4-related disease., PMID:38092138
EGF-Receptor against Amphiregulin (AREG) Influences Costimulatory Molecules on Monocytes and T Cells and Modulates T-Cell Responses., PMID:38046264
Prognostic and predictive biomarkers for anti-EGFR monoclonal antibody therapy in RAS wild-type metastatic colorectal cancer: a systematic review and meta-analysis., PMID:37974093
[Experimental study on the therapeutic effect and mechanism of erlotinib on non-proliferative diabetic retinopathy]., PMID:37936359
Towards Multiomics-Based Dissection of Anti-EGFR Sensitivity in Colorectal Cancer., PMID:37594733
LepR+ niche cell-derived AREG compromises hematopoietic stem cell maintenance under conditions of DNA repair deficiency and aging., PMID:37584437
Associations between AI-Assisted Tumor Amphiregulin and Epiregulin IHC and Outcomes from Anti-EGFR Therapy in the Routine Management of Metastatic Colorectal Cancer., PMID:37363997
Multi-Color-Emissive Magneto-Luminescent Nanoarchitectures for Targeted Identification of Heterogeneous Exosomes Associated with Lung Cancer Metastasis., PMID:37267204
XBP1-elicited environment by chemotherapy potentiates repopulation of tongue cancer cells by enhancing miR-22/lncRNA/KAT6B-dependent NF-κB signalling., PMID:36639835
Nuclear AREG affects a low-proliferative phenotype and contributes to drug resistance of melanoma., PMID:36054710
Regorafenib inhibits epithelial-mesenchymal transition and suppresses cholangiocarcinoma metastasis via YAP1-AREG axis., PMID:35449153
AREG is involved in scleral remodeling in form-deprivation myopia via the ERK1/2-MMP-2 pathway., PMID:35436023
Mechanisms for Alternaria alternata Function in the Skin During Induction of Peanut Allergy in Neonatal Mice With Skin Barrier Mutations., PMID:35387035
IL-17A Promotes Psoriasis-Associated Keratinocyte Proliferation through ACT1-Dependent Activation of YAP-AREG Axis., PMID:35304250
Combining gene expression analysis of gastric cancer cell lines and tumor specimens to identify biomarkers for anti-HER therapies-the role of HAS2, SHB and HBEGF., PMID:35264144
Prevalence of Inflammatory Pathways Over Immuno-Tolerance in Peripheral Blood Mononuclear Cells of Recent-Onset Type 1 Diabetes., PMID:35058920
Amphiregulin can predict treatment resistance to palliative first-line cetuximab plus FOLFIRI chemotherapy in patients with RAS wild-type metastatic colorectal cancer., PMID:34893673
Anti-tumor efficacy of an MMAE-conjugated antibody targeting cell surface TACE/ADAM17-cleaved Amphiregulin in breast cancer., PMID:34877472
Propofol induces apoptosis and ameliorates 5‑fluorouracil resistance in OSCC cells by reducing the expression and secretion of amphiregulin., PMID:34859260
Microglial-stimulation of glioma invasion involves the EGFR ligand amphiregulin., PMID:34843542
Cullin3 deficiency shapes tumor microenvironment and promotes cholangiocarcinoma in liver-specific Smad4/Pten mutant mice., PMID:34803491
DDX3 modulates the tumor microenvironment via its role in endoplasmic reticulum-associated translation., PMID:34568799
Risk-Predictive and Diagnostic Biomarkers for Colorectal Cancer; a Systematic Review of Studies Using Pre-Diagnostic Blood Samples Collected in Prospective Cohorts and Screening Settings., PMID:34503217
Serum Amphiregulin and Heparin-Binding Epidermal Growth Factor as Biomarkers in Patients with Idiopathic Inflammatory Myopathy., PMID:34442026
Targeting autocrine amphiregulin robustly and reproducibly inhibits ovarian cancer in a syngeneic model: roles for wildtype p53., PMID:33941851
Artificial Intelligence-Assisted Amphiregulin and Epiregulin IHC Predicts Panitumumab Benefit in RAS Wild-Type Metastatic Colorectal Cancer., PMID:33888518
Subconjunctival Injection of Regulatory T Cells Potentiates Corneal Healing Via Orchestrating Inflammation and Tissue Repair After Acute Alkali Burn., PMID:33326018
Amphiregulin Expression Is a Predictive Biomarker for EGFR Inhibition in Metastatic Colorectal Cancer: Combined Analysis of Three Randomized Trials., PMID:32943459
Contraceptive and molecular function of a novel recombinant vaccine based human leukemia inhibitory factor on Balb/c mice: An experimental in vivo study., PMID:32927320
Kidney GATA3+ regulatory T cells play roles in the convalescence stage after antibody-mediated renal injury., PMID:32917984
Amphiregulin Aggravates Glomerulonephritis via Recruitment and Activation of Myeloid Cells., PMID:32616537
Fibroblast growth factor receptor 4 increases epidermal growth factor receptor (EGFR) signaling by inducing amphiregulin expression and attenuates response to EGFR inhibitors in colon cancer., PMID:32533590
Knockdown of Amphiregulin Triggers Doxorubicin-Induced Autophagic and Apoptotic Death by Regulating Endoplasmic Reticulum Stress in Glioblastoma Cells., PMID:32472393
Clinical and molecular characteristics and treatment outcomes of advanced right-colon, left-colon and rectal cancers: data from 1180 patients in a phase III trial of panitumumab with an extended biomarker panel., PMID:32387453
Osimertinib Overcomes Alectinib Resistance Caused by Amphiregulin in a Leptomeningeal Carcinomatosis Model of ALK-Rearranged Lung Cancer., PMID:31972351
The dichotomous role of epiregulin in pain., PMID:31917773
For research use only. Not for human or drug use.
