Catalog No.
PHE71801
Species reactivity
Human
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human TSC2 (Asp1541-Asn1731).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
Tuberous sclerosis 2 protein, TSC2, TSC4, Tuberin
Purification
Purified by antigen affinity column.
Accession
P49815
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
HMGB1 mediates inflammation response of epileptogenicity in tuberous sclerosis complex-related epilepsy., PMID:40501216
Synergistic activity of tafasitamab and metronomic chemotherapy on diffuse large B-cell lymphoma through inhibition of the AKT/mTOR signaling pathway., PMID:40175588
CRISPR screens with trastuzumab emtansine in HER2-positive breast cancer cell lines reveal new insights into drug resistance., PMID:40165206
Molecular-based targeted therapies in patients with hepatocellular carcinoma and hepato-cholangiocarcinoma refractory to atezolizumab/bevacizumab., PMID:37647991
Complete Remission of a Diffuse Large B-Cell Lymphoma in a Young Patient, with Severe Tuberous Sclerosis, Treated with Metronomic Chemotherapy and Ibrutinib: A Case Report., PMID:37549660
Pulmonary Sarcoidosis: Experimental Models and Perspectives of Molecular Diagnostics Using Quantum Dots., PMID:37511027
A Phase I/II Investigation of Safety and Efficacy of Nivolumab and nab-Sirolimus in Patients With a Variety of Tumors With Genetic Mutations in the mTOR Pathway., PMID:37097693
Tuberous sclerosis complex is associated with a novel human tauopathy., PMID:36469115
Loss of TSC1/TSC2 sensitizes immune checkpoint blockade in non-small cell lung cancer., PMID:35119931
Differential Modulation of Matrix Metalloproteinases-2 and -7 in LAM/TSC Cells., PMID:34944575
Successful Immunotherapy for Pancreatic Cancer in a Patient With TSC2 and SMAD4 Mutations: A Case Report., PMID:34880877
Interleukin-6 mediates PSAT1 expression and serine metabolism in TSC2-deficient cells., PMID:34544857
Diagnostic and prognostic potential of the proteomic profiling of serum-derived extracellular vesicles in prostate cancer., PMID:34155195
Optimized EGFR Blockade Strategies in EGFR Addicted Gastroesophageal Adenocarcinomas., PMID:33542076
Tsc1 haploinsufficiency in Nkx2.1 cells upregulates hippocampal interneuron mTORC1 activity, impairs pyramidal cell synaptic inhibition, and alters contextual fear discrimination and spatial working memory in mice., PMID:32375878
Long non-coding RNA MALAT1 enhances the apoptosis of cardiomyocytes through autophagy inhibition by regulating TSC2-mTOR signaling., PMID:31783925
Immunotherapy for Lymphangioleiomyomatosis and Tuberous Sclerosis: Progress and Future Directions., PMID:31437431
Selenium nanoparticles for targeted stroke therapy through modulation of inflammatory and metabolic signaling., PMID:30988361
Durable response to anti-PD-1 immunotherapy in epithelioid angiomyolipoma: a report on the successful treatment of a rare malignancy., PMID:30285856
Butein Activates Autophagy Through AMPK/TSC2/ULK1/mTOR Pathway to Inhibit IL-6 Expression in IL-1β Stimulated Human Chondrocytes., PMID:30184535
Immune Checkpoint Ligand PD-L1 Is Upregulated in Pulmonary Lymphangioleiomyomatosis., PMID:30095976
IRF-1 SNPs influence the risk for childhood allergic asthma: A critical role for pro-inflammatory immune regulation., PMID:29047170
Mammalian target of rapamycin complex 1 activation sensitizes human glioma cells to hypoxia-induced cell death., PMID:28969371
p62/SQSTM1 Cooperates with Hyperactive mTORC1 to Regulate Glutathione Production, Maintain Mitochondrial Integrity, and Promote Tumorigenesis., PMID:28512249
Role of mTOR signaling pathway in the pathogenesis of subependymal giant cell astrocytoma - A study of 28 cases., PMID:27625244
Evidence Supporting a Lymphatic Endothelium Origin for Angiomyolipoma, a TSC2(-) Tumor Related to Lymphangioleiomyomatosis., PMID:27289491
Isolation of individual cellular components from lung tissues of patients with lymphangioleiomyomatosis., PMID:27016587
CHO cells knocked out for TSC2 display an improved productivity of antibodies under fed batch conditions., PMID:26888596
Lysosomal recruitment of TSC2 is a universal response to cellular stress., PMID:26868506
Co-activation of AMPK and mTORC1 Induces Cytotoxicity in Acute Myeloid Leukemia., PMID:26004183
Wild type mesenchymal cells contribute to the lung pathology of lymphangioleiomyomatosis., PMID:25978616
MCRS1 binds and couples Rheb to amino acid-dependent mTORC1 activation., PMID:25816988
TSC1 activates TGF-β-Smad2/3 signaling in growth arrest and epithelial-to-mesenchymal transition., PMID:25727005
Anti-EGFR antibody reduces lung nodules by inhibition of EGFR-pathway in a model of lymphangioleiomyomatosis., PMID:25699271
Oncotargets in different renal cancer subtypes., PMID:25619751
Lycopene in the prevention of renal cell cancer in the TSC2 mutant Eker rat model., PMID:25602702
New strategy for in vitro activation of primordial follicles with mTOR and PI3K stimulators., PMID:25590233
Antibody αPEP13h reacts with lymphangioleiomyomatosis cells in lung nodules., PMID:25411763
Tsc2 Haploinsufficiency Has Limited Effects on Fetal Brain Cytokine Levels during Gestational Immune Activation., PMID:25114803
Hyperactivation of Akt/mTOR and deficiency in tuberin increased the oxidative DNA damage in kidney cancer patients with diabetes., PMID:24797175
TSC2 epigenetic defect in primary LAM cells. Evidence of an anchorage-independent survival., PMID:24606538
Sirolimus decreases circulating lymphangioleiomyomatosis cells in patients with lymphangioleiomyomatosis., PMID:24051985
Mammalian target of rapamycin pathway activity in alveolar soft part sarcoma., PMID:23871289
Osteoprotegerin contributes to the metastatic potential of cells with a dysfunctional TSC2 tumor-suppressor gene., PMID:23867796
LAM cells biology and lymphangioleiomyomatosis., PMID:23690211
Positioning ganglioside D3 as an immunotherapeutic target in lymphangioleiomyomatosis., PMID:23665200
Chromatin remodeling by rosuvastatin normalizes TSC2-/meth cell phenotype through the expression of tuberin., PMID:23426956
Deletion of Rictor in neural progenitor cells reveals contributions of mTORC2 signaling to tuberous sclerosis complex., PMID:23049074
TSC2 modulates cell adhesion and migration via integrin-α1β1., PMID:22923640
Development of a lymphangioleiomyomatosis model by endonasal administration of human TSC2-/- smooth muscle cells in mice., PMID:22770663
For research use only. Not for human or drug use.
