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Research Grade Veltuzumab

Catalog #:   DHC90711 Specific References (100) DATASHEET
Host species: Humanized
Isotype: IgG1-kappa
Applications: Research Grade Biosimilar
Expression system: Mammalian Cells
Overview

Catalog No.

DHC90711

Expression system

Mammalian Cells

Species reactivity

Human

Host species

Humanized

Isotype

IgG1-kappa

Clonality

Monoclonal

Target

B-lymphocyte surface antigen B1, Membrane-spanning 4-domains subfamily A member 1, MS4A1, Leukocyte surface antigen Leu-16, B-lymphocyte antigen CD20, Bp35, CD20

Concentration

1 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

P11836

Applications

Research Grade Biosimilar

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Alternative Names

hA20 / IMMU-106, CAS: 728917-18-8

Clone ID

Veltuzumab

Data Image
  • SDS-PAGE
    SDS PAGE for Veltuzumab
References

Veltuzumab (humanized anti-CD20 monoclonal antibody): characterization, current clinical results, and future prospects, PMID: 20214444

Rituximab in B-Cell Hematologic Malignancies: A Review of 20 Years of Clinical Experience, PMID: 28983798

Novel therapies for immune-mediated inflammatory diseases: What can we learn from their use in rheumatoid arthritis, spondyloarthritis, systemic lupus erythematosus, psoriasis, Crohn's disease and ulcerative colitis?, PMID: 28765121

Treatment Update of Autoimmune Blistering Diseases, PMID: 30850044

Subcutaneous veltuzumab, a humanized anti-CD20 antibody, in the treatment of refractory pemphigus vulgaris, PMID: 25133328

Properties and structure-function relationships of veltuzumab (hA20), a humanized anti-CD20 monoclonal antibody, PMID: 18941114

Low-dose anti-CD20 veltuzumab given intravenously or subcutaneously is active in relapsed immune thrombocytopenia: a phase I study, PMID: 23829485

Subcutaneous injections of low-dose veltuzumab (humanized anti-CD20 antibody) are safe and active in patients with indolent non-Hodgkin's lymphoma, PMID: 21173095

Humanized anti-CD20 antibody, veltuzumab, in refractory/recurrent non-Hodgkin's lymphoma: phase I/II results, PMID: 19451441

Comparison of two dosing schedules for subcutaneous injections of low-dose anti-CD20 veltuzumab in relapsed immune thrombocytopenia, PMID: 27515248

Subcutaneous injections of low doses of humanized anti-CD20 veltuzumab: a phase I study in chronic lymphocytic leukemia, PMID: 26389849

Pretargeted versus directly targeted radioimmunotherapy combined with anti-CD20 antibody consolidation therapy of non-Hodgkin lymphoma, PMID: 19223402

The combination of milatuzumab, a humanized anti-CD74 antibody, and veltuzumab, a humanized anti-CD20 antibody, demonstrates activity in patients with relapsed and refractory B-cell non-Hodgkin lymphoma, PMID: 25847298

Anti-CD22 90Y-epratuzumab tetraxetan combined with anti-CD20 veltuzumab: a phase I study in patients with relapsed/refractory, aggressive non-Hodgkin lymphoma, PMID: 25150258

Veltuzumab, an anti-CD20 mAb for the treatment of non-Hodgkin's lymphoma, chronic lymphocytic leukemia and immune thrombocytopenic purpura, PMID: 19330725

Therapy of advanced B-lymphoma xenografts with a combination of 90Y-anti-CD22 IgG (epratuzumab) and unlabeled anti-CD20 IgG (veltuzumab), PMID: 18829494

Milatuzumab and veltuzumab induce apoptosis through JNK signalling in an NF-κB dependent human transformed follicular lymphoma cell line, PMID: 24386925

Rituximab resistance, PMID: 21658619

Bullous Diseases, PMID: 29131038

Future therapies for pemphigus vulgaris: Rituximab and beyond, PMID: 26792592

Novel agents for chronic lymphocytic leukemia, PMID: 23680477

Emerging immunological drugs for chronic lymphocytic leukemia, PMID: 26153226

B-cell depletion in immune thrombocytopenia, PMID: 23664523

New anti-CD20 monoclonal antibodies for the treatment of B-cell lymphoid malignancies, PMID: 21090841

CD20-targeted tetrameric interferon-alpha, a novel and potent immunocytokine for the therapy of B-cell lymphomas, PMID: 19710501

Novel CD20 monoclonal antibodies for lymphoma therapy, PMID: 23057966

Shifting Focus in the Therapeutics of Immunobullous Disease, PMID: 28584371

CD20-targeted therapy: the next generation of antibodies, PMID: 20350667

Multiple signaling pathways induced by hexavalent, monospecific, anti-CD20 and hexavalent, bispecific, anti-CD20/CD22 humanized antibodies correlate with enhanced toxicity to B-cell lymphomas and leukemias, PMID: 20628151

[Novel B-cell directed strategies for the treatment of rheumatic diseases], PMID: 19513729

Dancing partners at the ball: Rational selection of next generation anti-CD20 antibodies for combination therapy of chronic lymphocytic leukemia in the novel agents era, PMID: 28499646

Next-generation anti-CD20 monoclonal antibodies in autoimmune disease treatment, PMID: 29143151

Treatment strategies for nodal and gastrointestinal follicular lymphoma: current status and future development, PMID: 21105187

Current and emerging monoclonal antibody treatments for chronic lymphocytic leukemia: state of the art, PMID: 25249370

The future of CD20 monoclonal antibody therapy in B-cell malignancies, PMID: 20367564

Anti-CD22/CD20 Bispecific antibody with enhanced trogocytosis for treatment of Lupus, PMID: 24841238

Beyond rituximab: The future of monoclonal antibodies in B-cell non-Hodgkin lymphoma, PMID: 20425465

Epratuzumab-SN-38: a new antibody-drug conjugate for the therapy of hematologic malignancies, PMID: 22039078

Novel designs of multivalent anti-CD20 humanized antibodies as improved lymphoma therapeutics, PMID: 18922911

Optimization of multivalent bispecific antibodies and immunocytokines with improved in vivo properties, PMID: 23116517

Dual-targeting immunotherapy of lymphoma: potent cytotoxicity of anti-CD20/CD74 bispecific antibodies in mantle cell and other lymphomas, PMID: 22271448

Bispecific anti-CD20/22 antibodies inhibit B-cell lymphoma proliferation by a unique mechanism of action, PMID: 18025153

Hexavalent bispecific antibodies represent a new class of anticancer therapeutics: 1. Properties of anti-CD20/CD22 antibodies in lymphoma, PMID: 19372261

Improving the treatment of non-Hodgkin lymphoma with antibody-targeted radionuclides, PMID: 20127947

Variable contribution of monoclonal antibodies to ADCC in patients with chronic lymphocytic leukemia, PMID: 19562616

Hepatocyte paraffin 1 immunoexpression in esophageal brush samples, PMID: 15918175

A bispecific antibody-IFNalpha2b immunocytokine targeting CD20 and HLA-DR is highly toxic to human lymphoma and multiple myeloma cells, PMID: 20876805

Improved therapy of non-Hodgkin's lymphoma xenografts using radionuclides pretargeted with a new anti-CD20 bispecific antibody, PMID: 15815716

Three different B-cell depletion (anti-CD20 monoclonal antibodies) treatments for severe resistant systemic lupus erythematosus, PMID: 20534646

Interferon-λ1 linked to a stabilized dimer of Fab potently enhances both antitumor and antiviral activities in targeted cells, PMID: 23696859

Biologics in Systemic Lupus Erythematosus: Recent Evolutions and Benefits., PMID:39339212

Immunotherapy in indolent Non-Hodgkin's Lymphoma., PMID:35663281

Epitope Mapping of Rituximab Using HisMAP Method., PMID:35225667

Systematic Review of Safety and Efficacy of Second- and Third-Generation CD20-Targeting Biologics in Treating Immune-Mediated Disorders., PMID:35185862

Complicated Diagnosis and Treatment of HA20 due to Contiguous Gene Deletions involving 6q23.3., PMID:34032947

Treatment Update of Autoimmune Blistering Diseases., PMID:30850044

Next-generation anti-CD20 monoclonal antibodies in autoimmune disease treatment., PMID:29143151

Bullous Diseases., PMID:29131038

Rituximab in B-Cell Hematologic Malignancies: A Review of 20 Years of Clinical Experience., PMID:28983798

Novel therapies for immune-mediated inflammatory diseases: What can we learn from their use in rheumatoid arthritis, spondyloarthritis, systemic lupus erythematosus, psoriasis, Crohn's disease and ulcerative colitis?, PMID:28765121

Shifting Focus in the Therapeutics of Immunobullous Disease., PMID:28584371

Dancing partners at the ball: Rational selection of next generation anti-CD20 antibodies for combination therapy of chronic lymphocytic leukemia in the novel agents era., PMID:28499646

Comparison of two dosing schedules for subcutaneous injections of low-dose anti-CD20 veltuzumab in relapsed immune thrombocytopenia., PMID:27515248

Future therapies for pemphigus vulgaris: Rituximab and beyond., PMID:26792592

Subcutaneous injections of low doses of humanized anti-CD20 veltuzumab: a phase I study in chronic lymphocytic leukemia., PMID:26389849

Emerging immunological drugs for chronic lymphocytic leukemia., PMID:26153226

The combination of milatuzumab, a humanized anti-CD74 antibody, and veltuzumab, a humanized anti-CD20 antibody, demonstrates activity in patients with relapsed and refractory B-cell non-Hodgkin lymphoma., PMID:25847298

Current and emerging monoclonal antibody treatments for chronic lymphocytic leukemia: state of the art., PMID:25249370

Anti-CD22 90Y-epratuzumab tetraxetan combined with anti-CD20 veltuzumab: a phase I study in patients with relapsed/refractory, aggressive non-Hodgkin lymphoma., PMID:25150258

Subcutaneous veltuzumab, a humanized anti-CD20 antibody, in the treatment of refractory pemphigus vulgaris., PMID:25133328

Anti-CD22/CD20 Bispecific antibody with enhanced trogocytosis for treatment of Lupus., PMID:24841238

Milatuzumab and veltuzumab induce apoptosis through JNK signalling in an NF-κB dependent human transformed follicular lymphoma cell line., PMID:24386925

Low-dose anti-CD20 veltuzumab given intravenously or subcutaneously is active in relapsed immune thrombocytopenia: a phase I study., PMID:23829485

Interferon-λ1 linked to a stabilized dimer of Fab potently enhances both antitumor and antiviral activities in targeted cells., PMID:23696859

Novel agents for chronic lymphocytic leukemia., PMID:23680477

B-cell depletion in immune thrombocytopenia., PMID:23664523

Optimization of multivalent bispecific antibodies and immunocytokines with improved in vivo properties., PMID:23116517

Novel CD20 monoclonal antibodies for lymphoma therapy., PMID:23057966

Dual-targeting immunotherapy of lymphoma: potent cytotoxicity of anti-CD20/CD74 bispecific antibodies in mantle cell and other lymphomas., PMID:22271448

Epratuzumab-SN-38: a new antibody-drug conjugate for the therapy of hematologic malignancies., PMID:22039078

Rituximab resistance., PMID:21658619

Subcutaneous injections of low-dose veltuzumab (humanized anti-CD20 antibody) are safe and active in patients with indolent non-Hodgkin's lymphoma., PMID:21173095

Treatment strategies for nodal and gastrointestinal follicular lymphoma: current status and future development., PMID:21105187

New anti-CD20 monoclonal antibodies for the treatment of B-cell lymphoid malignancies., PMID:21090841

A bispecific antibody-IFNalpha2b immunocytokine targeting CD20 and HLA-DR is highly toxic to human lymphoma and multiple myeloma cells., PMID:20876805

Multiple signaling pathways induced by hexavalent, monospecific, anti-CD20 and hexavalent, bispecific, anti-CD20/CD22 humanized antibodies correlate with enhanced toxicity to B-cell lymphomas and leukemias., PMID:20628151

Three different B-cell depletion (anti-CD20 monoclonal antibodies) treatments for severe resistant systemic lupus erythematosus., PMID:20534646

The future of CD20 monoclonal antibody therapy in B-cell malignancies., PMID:20367564

CD20-targeted therapy: the next generation of antibodies., PMID:20350667

Veltuzumab (humanized anti-CD20 monoclonal antibody): characterization, current clinical results, and future prospects., PMID:20214444

Improving the treatment of non-Hodgkin lymphoma with antibody-targeted radionuclides., PMID:20127947

CD20-targeted tetrameric interferon-alpha, a novel and potent immunocytokine for the therapy of B-cell lymphomas., PMID:19710501

Variable contribution of monoclonal antibodies to ADCC in patients with chronic lymphocytic leukemia., PMID:19562616

[Novel B-cell directed strategies for the treatment of rheumatic diseases]., PMID:19513729

Humanized anti-CD20 antibody, veltuzumab, in refractory/recurrent non-Hodgkin's lymphoma: phase I/II results., PMID:19451441

Hexavalent bispecific antibodies represent a new class of anticancer therapeutics: 1. Properties of anti-CD20/CD22 antibodies in lymphoma., PMID:19372261

Veltuzumab, an anti-CD20 mAb for the treatment of non-Hodgkin's lymphoma, chronic lymphocytic leukemia and immune thrombocytopenic purpura., PMID:19330725

Pretargeted versus directly targeted radioimmunotherapy combined with anti-CD20 antibody consolidation therapy of non-Hodgkin lymphoma., PMID:19223402

Properties and structure-function relationships of veltuzumab (hA20), a humanized anti-CD20 monoclonal antibody., PMID:18941114

Novel designs of multivalent anti-CD20 humanized antibodies as improved lymphoma therapeutics., PMID:18922911

Datasheet

Document Download

Research Grade Veltuzumab.pdf

 

$ 328
Product specifications
100 μg 328 1 mg 1314

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Research Grade Veltuzumab [DHC90711]
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