Catalog No.
PHC94101
Species reactivity
Human
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human GZMA (Ile29-Val262).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
H factor,CTLA3,Cytotoxic T-lymphocyte proteinase 1,CTL tryptase,Fragmentin-1,HFSP,HF,Granzyme A,Granzyme-1,GZMA,Hanukkah factor
Purification
Purified by antigen affinity column.
Accession
P12544
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
A novel plant-derived recombinant COBRA infectious bronchitis virus spike protein can elicit a strong immune response in chickens., PMID:40358746
The immune cell dynamics in the peripheral blood of cHL patients receiving anti-PD1 treatment., PMID:40182035
Spatially Resolved, Multiregion Proteomics for Prediction of Immunotherapy Outcome in Deficient Mismatch Repair Metastatic Colorectal Cancer., PMID:39969975
Gene Expression Profiling of the Peritumoral Immune Cell Infiltrate of Penile Squamous Cell Carcinomas., PMID:39596210
An exploratory clinical study of β-glucan combined with camrelizumab and SOX chemotherapy as first-line treatment for advanced gastric adenocarcinoma., PMID:39253086
Selective Detection of Active Extracellular Granzyme A by Using a Novel Fluorescent Immunoprobe with Application to Inflammatory Diseases., PMID:38751645
Differentially Expressed Genes Involved in Primary Resistance to Immunotherapy in Patients with Advanced-Stage Pulmonary Cancer., PMID:38396726
Deciphering the immune landscape of head and neck squamous cell carcinoma: A single-cell transcriptomic analysis of regulatory T cell responses to PD-1 blockade therapy., PMID:38096229
Immune dysfunction revealed by digital spatial profiling of immuno-oncology markers in progressive stages of renal cell carcinoma and in brain metastases., PMID:37586773
Identification of pre-infection markers and differential plasma protein expression following SARS-CoV-2 infection in people living with HIV., PMID:36966617
Nasal administration of anti-CD3 mAb (Foralumab) downregulates NKG7 and increases TGFB1 and GIMAP7 expression in T cells in subjects with COVID-19., PMID:36881624
Neurobiochemical, Peptidomic, and Bioinformatic Approaches to Characterize Tauopathy Peptidome Biomarker Candidates in Experimental Mouse Model of Traumatic Brain Injury., PMID:36635478
Chimeric immune checkpoint protein vaccines inhibit the tumorigenesis and growth of rat cholangiocarcinoma., PMID:36341387
A Single-Cell Atlas of Lymphocyte Adaptive Immune Repertoires and Transcriptomes Reveals Age-Related Differences in Convalescent COVID-19 Patients., PMID:34322127
Identification of Macrophage Polarization-Related Genes as Biomarkers of Chronic Obstructive Pulmonary Disease Based on Bioinformatics Analyses., PMID:34250093
Identification of CD8+ T Cell-Related Genes: Correlations with Immune Phenotypes and Outcomes of Liver Cancer., PMID:34124275
Angiogenic and Immune-Related Biomarkers and Outcomes Following Axitinib/Pembrolizumab Treatment in Patients with Advanced Renal Cell Carcinoma., PMID:32816890
Decrease in immune function and the role of mitogen-activated protein kinase (MAPK) overactivation in apoptosis during T lymphocytes activation induced by zearalenone, deoxynivalenol, and their combinations., PMID:32679628
SerpinB1 controls encephalitogenic T helper cells in neuroinflammation., PMID:31548399
PD-1/PD-L1 Immune Checkpoint Inhibition with Radiation in Bladder Cancer: In Situ and Abscopal Effects., PMID:31534011
Signaling Lymphocytic Activation Molecule Family Member 7 Engagement Restores Defective Effector CD8+ T Cell Function in Systemic Lupus Erythematosus., PMID:28076903
Lesional CD4+ IFN-γ+ cytotoxic T lymphocytes in IgG4-related dacryoadenitis and sialoadenitis., PMID:27358392
Granzyme A impairs host defense during Streptococcus pneumoniae pneumonia., PMID:27343190
Cytotoxic CD4+ T cells are correlated with better prognosis in Han Chinese grade II and grade III glioma subjects and are suppressed by PD-1 signaling., PMID:27167139
TGF-β-Induced Regulatory T Cells Directly Suppress B Cell Responses through a Noncytotoxic Mechanism., PMID:27001954
Association Between Response to Etrolizumab and Expression of Integrin αE and Granzyme A in Colon Biopsies of Patients With Ulcerative Colitis., PMID:26522261
Genetic deletion of granzyme B does not confer resistance to the development of spontaneous diabetes in non-obese diabetic mice., PMID:23663075
Postexposure treatment with the live-attenuated rabies virus (RV) vaccine TriGAS triggers the clearance of wild-type RV from the Central Nervous System (CNS) through the rapid induction of genes relevant to adaptive immunity in CNS tissues., PMID:22238315
Role of the inflammatory protein serine protease inhibitor Kazal in preventing cytolytic granule granzyme A-mediated apoptosis., PMID:22043941
Capsaicin promotes a more aggressive gene expression phenotype and invasiveness in null-TRPV1 urothelial cancer cells., PMID:21310942
A novel and divergent role of granzyme A and B in resistance to helminth infection., PMID:21248253
Transcriptional analysis of host responses to Marek's disease virus infection in genetically resistant and susceptible chickens., PMID:18371127
Ligation of CD8alpha on human natural killer cells prevents activation-induced apoptosis and enhances cytolytic activity., PMID:16236125
Differential expression of granzymes A and B in human cytotoxic lymphocyte subsets and T regulatory cells., PMID:15238416
Cationic lipid gene transfer of an IL-2 transgene leads to activation of natural killer cells in a SCID mouse human tumor xenograft., PMID:11069717
Gammadelta receptor bearing T cells in scleroderma: enhanced interaction with vascular endothelial cells in vitro., PMID:10227811
Extracellular granzymes A and B in humans: detection of native species during CTL responses in vitro and in vivo., PMID:9531325
Can histopathology guide immunosuppression for cardiac allograft rejection in the light of new techniques?, PMID:9414672
The participation of the Fas-mediated cytotoxic pathway by natural killer cells is tumor-cell-dependent., PMID:9247563
Role of perforin, granzymes and the proliferative state of the target cells in apoptosis and necrosis mediated by bispecific-antibody-activated cytotoxic T cells., PMID:9177467
Mechanism of serum-mediated endothelial injury in scleroderma: identification of a granular enzyme in scleroderma skin and sera., PMID:9073533
Inhibition of CPP32-like proteases prevents granzyme B- and Fas-, but not granzyme A-based cytotoxicity exerted by CTL clones., PMID:9036942
Expression of human recombinant granzyme A zymogen and its activation by the cysteine proteinase cathepsin C., PMID:8621589
Two pathways of exocytosis of cytoplasmic granule contents and target cell killing by cytokine-induced CD3+ CD56+ killer cells., PMID:7579455
Loss of cytotoxic T lymphocyte function in Chediak-Higashi syndrome arises from a secretory defect that prevents lytic granule exocytosis., PMID:7751653
Localization and identification of granzymes A and B-expressing cells in normal human lymphoid tissue and peripheral blood., PMID:7697916
Demonstration of granzyme A and perforin messenger RNA in the synovium of patients with rheumatoid arthritis., PMID:7536415
Expression of granzyme A and B proteins by cytotoxic lymphocytes involved in acute renal allograft rejection., PMID:7731173
Granzyme-positive cytotoxic cells are specifically increased in early rheumatoid synovial tissue., PMID:7986219
Immunohistochemical analysis of perforin and granzyme A in inflammatory myopathies., PMID:7919969
For research use only. Not for human or drug use.
