Catalog No.
PHE28701
Species reactivity
Human
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human PMEL (Gln65-Thr299).
Applications
ELISA, IHC, WB
Recommended Dilution
| Application |
Dilution |
| ELISA |
1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000 |
Target
ME20M, Melanocyte protein PMEL, Silver locus protein homolog, Secreted melanoma-associated ME20 antigen, D12S53E, 95 kDa melanocyte-specific secreted glycoprotein, SILV, P100, Premelanosome protein, PMEL17, ME20S, PMEL, ME20-S, ME20-M, P26, P1, Melanocytes lineage-specific antigen GP100, Melanocyte protein Pmel 17, Melanoma-associated ME20 antigen
Purification
Purified by antigen affinity column.
Accession
P40967
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Note
For research use only.
Antiangiogenic agents can increase lymphocyte infiltration into tumor and enhance the effectiveness of adoptive immunotherapy of cancer., PMID:20631075
The tetraspanin CD63 regulates ESCRT-independent and -dependent endosomal sorting during melanogenesis., PMID:21962903
The use of immunocytochemical study in the cytologic diagnosis of melanoma: evaluation of three antibodies., PMID:22021247
Primary oral melanoma: a histopathological and immunohistochemical study of 22 cases of Latin America., PMID:22143732
Epithelioid angiosarcoma of bone and soft tissue: a report of seven cases with emphasis on morphologic diversity, immunohistochemical features and clinical outcome., PMID:22158488
Aberrant expression of HMB-45 in traumatized melanocytic nevi., PMID:22285619
A mouse model of vitiligo with focused epidermal depigmentation requires IFN-γ for autoreactive CD8⁺ T-cell accumulation in the skin., PMID:22297636
Perivascular epithelioid cell tumor (PEComa) of gynecologic origin: a clinicopathological study of three cases., PMID:22439417
The melanosomal protein PMEL17 as a target for antibody drug conjugate therapy in melanoma., PMID:22613716
Inhibition of TGF-β signaling in genetically engineered tumor antigen-reactive T cells significantly enhances tumor treatment efficacy., PMID:22972494
Metastatic melanoma presenting as an isolated breast tumor: a study of 20 cases with emphasis on several primary mimickers., PMID:23276173
A multifunctional chimeric chaperone serves as a novel immune modulator inducing therapeutic antitumor immunity., PMID:23333935
[Detection of serum autoantibodies against premelanosome protein 17 increases in the vitiligo patients]., PMID:23643172
Value of melanocytic-associated immunohistochemical markers in the diagnosis of malignant melanoma: a review and update., PMID:23648379
Marginal and joint distributions of S100, HMB-45, and Melan-A across a large series of cutaneous melanomas., PMID:23899062
Cytotoxic T lymphocyte antigen-4 blockade enhances antitumor immunity by stimulating melanoma-specific T-cell motility., PMID:25038199
A monoclonal antibody against PMEL., PMID:25118787
Cytotoxic T lymphocytes block tumor growth both by lytic activity and IFNγ-dependent cell-cycle arrest., PMID:25127875
Hyperosmotic stress reduces melanin production by altering melanosome formation., PMID:25170965
Antibody αPEP13h reacts with lymphangioleiomyomatosis cells in lung nodules., PMID:25411763
Metastatic melanoma of the tongue: a case report with immunohistochemical profile., PMID:25427453
Improved antitumor activity of immunotherapy with BRAF and MEK inhibitors in BRAF(V600E) melanoma., PMID:25787767
Hashimoto's thyroiditis could be secondary to vitiligo: the possibility of antigen crossover and oxidative stress between the two diseases., PMID:27020052
Isolating RNA from precursor and mature melanocytes from human vitiligo and normal skin using laser capture microdissection., PMID:27193292
Cross-talk between 4-1BB and TLR1-TLR2 Signaling in CD8+ T Cells Regulates TLR2's Costimulatory Effects., PMID:27267778
Increased Activity and Number of Epidermal Melanocytes in Lesional Psoriatic Skin., PMID:27497917
The stress kinase GCN2 does not mediate suppression of antitumor T cell responses by tryptophan catabolism in experimental melanomas., PMID:28123877
Hepatic perivascular epithelioid cell tumor (PEComa): a case report with a review of literatures., PMID:28288506
Blockade of surface-bound TGF-β on regulatory T cells abrogates suppression of effector T cell function in the tumor microenvironment., PMID:28851824
Radiologic and Histopathologic Correlation of Different Growth Patterns of Metastatic Uveal Melanoma to the Liver., PMID:29122287
ABCB6 Resides in Melanosomes and Regulates Early Steps of Melanogenesis Required for PMEL Amyloid Matrix Formation., PMID:29940187
Utility of p16-Ki-67-HMB45 score in sorting benign from malignant Spitz tumors., PMID:31351802
Optimizing T-cell receptor avidity with somatic hypermutation., PMID:31381134
PNL2: A Useful Adjunct Biomarker to HMB45 in the Diagnosis of Uterine Perivascular Epithelioid Cell Tumor (PEComa)., PMID:31851063
CD10 and p63 expression in a sarcomatoid undifferentiated melanoma: A cautionary (and molecularly annotated) tale., PMID:31943331
SLAMF6 deficiency augments tumor killing and skews toward an effector phenotype revealing it as a novel T cell checkpoint., PMID:32122464
Indication of Premelanosome Protein (PMEL) Expression Outside of Pigmented Bovine Skin Suggests Functions Beyond Eumelanogenesis., PMID:32668786
Rapid tumor vaccine using Toll-like receptor-activated ovarian cancer ascites monocytes., PMID:32817208
Autoimmune response against tyrosinase induces depigmentation in C57BL/6 black mice., PMID:33084421
Primary leptomeningeal melanomatosis successfully treated with PD-1 inhibitor pembrolizumab: A case report., PMID:33327228
Dry Formulation of Virus-Like Particles in Electrospun Nanofibers., PMID:33802376
CCL17-CCR4 axis contributes to the onset of vitiligo in mice., PMID:34077992
Adiponectin negatively regulates pigmentation, Wnt/β-catenin and HGF/c-Met signalling within human scalp hair follicles ex vivo., PMID:34854998
Increased LCN2 (lipocalin 2) in the RPE decreases autophagy and activates inflammasome-ferroptosis processes in a mouse model of dry AMD., PMID:35473441
Requirements for anti-aquaporin 5 autoantibody production in a mouse model., PMID:37718989
β-Catenin in Dendritic Cells Negatively Regulates CD8 T Cell Immune Responses through the Immune Checkpoint Molecule Tim-3., PMID:38793711
PRAME and Historical Immunohistochemical Antibodies Ki-67, P16, and HMB-45 in Ambiguous Melanocytic Tumors., PMID:38916203
In Situ Protein Expression Analysis of Melanocyte Differentiation Antigen TRP1 (Tyrosinase-Related Protein-1)., PMID:39008470
[Clinicopathological features of metastatic melanoma in effusion cytology of serosal cavity]., PMID:39103266
CD93 blockade promotes effector T-cell infiltration and facilitates adoptive cell therapy in solid tumors., PMID:39805660
For research use only. Not for human or drug use.
