Catalog No.
PHC85601
Species reactivity
Human, Mouse, Rat
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human HSPA8 (Asp534-Gly615).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
Lipopolysaccharide-associated protein 1,HSPA10,Heat shock 70 kDa protein 8,LPS-associated protein 1,LAP-1,HSP73,HSC70,HSPA8,Heat shock cognate 71 kDa protein
Purification
Purified by antigen affinity column.
Accession
P11142
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Anti-TNFα and Anti-IL-1β Monoclonal Antibodies Preserve BV-2 Microglial Homeostasis Under Hypoxia by Mitigating Inflammatory Reactivity and ATF4/MAPK-Mediated Apoptosis., PMID:40338234
Rituximab-Chidamide combination chemotherapy enhances autophagy to overcome drug resistance in diffuse large B-cell lymphoma., PMID:40258315
Proximity proteomics reveals unique and shared pathological features between multiple system atrophy and Parkinson's disease., PMID:40122840
Comparing alpha-synuclein-interactomes between multiple systems atrophy and Parkinson's disease reveals unique and shared pathological features., PMID:39345456
SHISA3 Reprograms Tumor-Associated Macrophages Toward an Antitumoral Phenotype and Enhances Cancer Immunotherapy., PMID:39054639
Hsc70 promotes anti-tumor immunity by targeting PD-L1 for lysosomal degradation., PMID:38762492
Identification of key genes and imbalance of immune cell infiltration in immunoglobulin A associated vasculitis nephritis by integrated bioinformatic analysis., PMID:37026011
The Effect of the Histone Chaperones HSPA8 and DEK on Tumor Immunity in Hepatocellular Carcinoma., PMID:36768989
Immunohistochemical Detection of the Chaperone-Mediated Autophagy Markers LAMP2A and HSPA8 in Formalin-Fixed and Paraffin-Embedded Tissues., PMID:36152248
Heat Shock Protein Member 8 (HSPA8) Is Involved in Porcine Reproductive and Respiratory Syndrome Virus Attachment and Internalization., PMID:35138165
Proteomic identification of arginine-methylated proteins in colon cancer cells and comparison of messenger RNA expression between colorectal cancer and adjacent normal tissues., PMID:35081685
Stress-induced phosphoprotein 1 restrains spinal cord ischaemia-reperfusion injury by modulating NF-κB signalling., PMID:34734476
Chaperone-Mediated Autophagy Markers LAMP2A and HSPA8 in Advanced Non-Small Cell Lung Cancer after Neoadjuvant Therapy., PMID:34685711
Extracellular Vesicle and Particle Biomarkers Define Multiple Human Cancers., PMID:32795414
Heat Shock Protein Member 8 Is an Attachment Factor for Infectious Bronchitis Virus., PMID:32765462
Functional surface proteomic profiling reveals the host heat-shock protein A8 as a mediator of Lichtheimia corymbifera recognition by murine alveolar macrophages., PMID:32583550
Chaperone-assisted selective autophagy in healthy and papillomavirus-associated neoplastic urothelium of cattle., PMID:29981700
Small and big Hodgkin-Reed-Sternberg cells of Hodgkin lymphoma cell lines L-428 and L-1236 lack consistent differences in gene expression profiles and are capable to reconstitute each other., PMID:28505189
Fatty acid synthase inhibits the O-GlcNAcase during oxidative stress., PMID:28232487
The Mesenchymal Precursor Cell Marker Antibody STRO-1 Binds to Cell Surface Heat Shock Cognate 70., PMID:28026090
Chaperone-mediated autophagy regulates proliferation by targeting RND3 in gastric cancer., PMID:26761524
Circulating Autoantibodies in Age-Related Macular Degeneration Recognize Human Macular Tissue Antigens Implicated in Autophagy, Immunomodulation, and Protection from Oxidative Stress and Apoptosis., PMID:26717306
Serological proteome analysis reveals new specific biases in the IgM and IgG autoantibody repertoires in autoimmune polyendocrine syndrome type 1., PMID:26312540
Serum reactivity against herpes simplex virus type 1 UL48 protein in Behçet's disease patients and a Behçet's disease-like mouse model., PMID:25916670
Electrophoretic and immunocytochemical analysis of Hsp72 and Hsp73 expression in heat-stressed mouse testis and epididymis., PMID:23352621
70-kDa heat shock cognate protein hsc70 mediates calmodulin-dependent nuclear import of the sex-determining factor SRY., PMID:23235156
Sustained productivity in recombinant Chinese hamster ovary (CHO) cell lines: proteome analysis of the molecular basis for a process-related phenotype., PMID:21781345
Comment to: Humanization of a mouse monoclonal antibody directed against a cell surface-exposed epitope of membrane-associated heat shock protein 70 (Hsp70)., PMID:20668964
Exosomes from human lymphoblastoid B cells express enzymatically active CD38 that is associated with signaling complexes containing CD81, Hsc-70 and Lyn., PMID:20570673
Hispolon promotes MDM2 downregulation through chaperone-mediated autophagy., PMID:20540933
Insulin-degrading enzyme binds to the nonglycosylated precursor of varicella-zoster virus gE protein found in the endoplasmic reticulum., PMID:19864391
Chromatin-associated proteins HMGB1/2 and PDIA3 trigger cellular response to chemotherapy-induced DNA damage., PMID:19372559
Effects of oviductal proteins, including heat shock 70 kDa protein 8, on survival of ram spermatozoa over 48 h in vitro., PMID:19261218
Heat shock cognate protein 70 contributes to Brucella invasion into trophoblast giant cells that cause infectious abortion., PMID:19055850
Effects of HSPA8, an evolutionarily conserved oviductal protein, on boar and bull spermatozoa., PMID:18996976
Long-term exposure to low lithium concentrations stimulates proliferation, modifies stress protein expression pattern and enhances resistance to oxidative stress in SH-SY5Y cells., PMID:18688712
Critical role of extracellular heat shock cognate protein 70 in the myocardial inflammatory response and cardiac dysfunction after global ischemia-reperfusion., PMID:18441202
The clinical significance of anti-heat shock cognate protein 71 antibody in myasthenia gravis., PMID:17981040
Heat shock 70-kDa protein 8 isoform 1 is expressed on the surface of human embryonic stem cells and downregulated upon differentiation., PMID:16100000
Different sources of "help" facilitate the antibody response to hepatitis D virus delta antigen., PMID:15776288
Effects of nickel poisoning on expression pattern of the 72/73 and 94 kDa stress proteins in rat organs and in the COS-7, HepG2, and A549 cell lines., PMID:15736156
Identification of proteins binding the native tubulin dimer., PMID:15629426
Intracellular localization of constitutive and inducible heat shock protein 70 in rat liver after in vivo heat stress., PMID:15543931
Novel biomarker of HTLV-1-associated disease: specific appearance of antibody recognizing the receptor-binding site on HTLV-1 envelope protein., PMID:15504252
N-myristoyltransferase inhibitor protein is homologous to heat shock cognate protein 70., PMID:15156568
Gene expression profiles define a key checkpoint for type 1 diabetes in NOD mice., PMID:14747287
Continuous enhanced expression of Hsc70 but not Hsp70 in rheumatoid arthritis synovial tissue., PMID:14730603
Antibodies to HSP-70 in normal donors and autoimmune hearing loss patients., PMID:14520104
T-cell receptor variable gamma chain gene expression in the interaction between rat gammadelta-type T cells and heat-shock protein 70-like molecule., PMID:12825896
Prevalence of HSP47 antigen and autoantibodies to HSP47 in the sera of patients with mixed connective tissue disease., PMID:12659832
For research use only. Not for human or drug use.
