Catalog No.
YHK78701
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ser21-Gln180
Predicted molecular weight
20.49 kDa
Nature
Recombinant
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q96NA2
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Rab-interacting lysosomal protein, RILP
Note
For research use only.
Charcot-Marie-Tooth Type 2B: A New Phenotype Associated with a Novel RAB7A Mutation and Inhibited EGFR Degradation., PMID:32326241
NRBF2 is a RAB7 effector required for autophagosome maturation and mediates the association of APP-CTFs with active form of RAB7 for degradation., PMID:32543313
A RILP-regulated pathway coordinating autophagosome biogenesis with transport., PMID:32597306
Identification of key genes in ruptured atherosclerotic plaques by weighted gene correlation network analysis., PMID:32616722
A comprehensive analysis of Rab GTPases reveals a role for Rab34 in serum starvation-induced primary ciliogenesis., PMID:32669361
ATM loss disrupts the autophagy-lysosomal pathway., PMID:32757690
The RNA binding protein FMR1 controls selective exosomal miRNA cargo loading during inflammation., PMID:32970791
Inflammasomes: Exosomal miRNAs loaded for action., PMID:32970793
RILP gets cleaved and exosomes leave., PMID:32989292
Methylation of RILP in lung cancer promotes tumor cell proliferation and invasion., PMID:33128214
Deciphering the LRRK code: LRRK1 and LRRK2 phosphorylate distinct Rab proteins and are regulated by diverse mechanisms., PMID:33459343
Role of the V1G1 subunit of V-ATPase in breast cancer cell migration., PMID:33633298
Roles of the multivalent dynein adaptors BicD2 and RILP in neurons., PMID:33667600
Vps34 Inhibits Hepatocellular Carcinoma Invasion by Regulating Endosome-Lysosome Trafficking via Rab7-RILP and Rab11., PMID:33781048
Biochemical and structural insights into Rab12 interactions with RILP and its family members., PMID:33986343
CLN5 and CLN3 function as a complex to regulate endolysosome function., PMID:34060589
Amyloid-β oligomers block lysosomal targeting of miRNPs to prevent miRNP recycling and target repression in glial cells., PMID:34096603
DYNC1LI2 regulates localization of the chaperone-mediated autophagy receptor LAMP2A and improves cellular homeostasis in cystinosis., PMID:34643468
Improving Lipophagy by Restoring Rab7 Cycle: Protective Effects of Quercetin on Ethanol-Induced Liver Steatosis., PMID:35277017
Dynein Is Required for Rab7-Dependent Endosome Maturation, Retrograde Dendritic Transport, and Degradation., PMID:35474277
JIP3 interacts with dynein and kinesin-1 to regulate bidirectional organelle transport., PMID:35829703
RILP inhibits proliferation, migration, and invasion of PC3 prostate cancer cells., PMID:35981451
Lysosomal positioning regulates Rab10 phosphorylation at LRRK2+ lysosomes., PMID:36256825
Loss of small GTPase Rab7 activation in prion infection negatively affects a feedback loop regulating neuronal cholesterol metabolism., PMID:36623732
A Novel Role for RILP in Regulating Osteoclastogenesis and Bone Resorption., PMID:36801641
Lipid droplets as multifunctional organelles related to the mechanism of evasion during mycobacterial infection., PMID:36909724
"Disruption of Golgi markers by two RILP-directed shRNAs in neurons: a new role for RILP or a neuron-specific off-target phenotype?"., PMID:36945482
Inflammatory macrophage to hepatocyte signals can be prevented by extracellular vesicle reprogramming., PMID:37051862
Disruption of Golgi markers by two RILP-directed shRNAs in neurons: A new role for RILP or a neuron-specific off-target phenotype?, PMID:37315786
A low-temperature digital microfluidic system used for protein-protein interaction detection., PMID:37721054
RILP inhibits tumor progression in osteosarcoma via Grb10-mediated inhibition of the PI3K/AKT/mTOR pathway., PMID:37789274
Functional assessment of lysosomal Rab7 and RILP with RNA interference and overexpression in Spodoptera frugiperda Sf9 cell lines., PMID:37851568
Collapse of late endosomal pH elicits a rapid Rab7 response via V-ATPase and RILP., PMID:37961579
TRIM25 dictates selective miRNA loading into extracellular vesicles during inflammation., PMID:38135735
DENND6A links Arl8b to a Rab34/RILP/dynein complex, regulating lysosomal positioning and autophagy., PMID:38296963
Collapse of late endosomal pH elicits a rapid Rab7 response via the V-ATPase and RILP., PMID:38578235
Septin-coated microtubules promote maturation of multivesicular bodies by inhibiting their motility., PMID:38668767
Autophagy initiation triggers p150Glued-AP-2β interaction on the lysosomes and facilitates their transport., PMID:38758395
Legionella effectors SidC/SdcA ubiquitinate multiple small GTPases and SNARE proteins to promote phagosomal maturation., PMID:38836877
Targeting Rab7-Rilp Mediated Microlipophagy Alleviates Lipid Toxicity in Diabetic Cardiomyopathy., PMID:38837607
Cholesterol-rich lysosomes induced by respiratory syncytial virus promote viral replication by blocking autophagy flux., PMID:39060258
RILP Induces Cholesterol Accumulation in Lysosomes by Inhibiting Endoplasmic Reticulum-Endolysosome Interactions., PMID:39195203
Systems mapping of bidirectional endosomal transport through the crowded cell., PMID:39276769
Photoprotective Melanin Is Maintained within Keratinocytes in Storage Lysosomes., PMID:39303907
USP5-dependent HDAC1 promotes cisplatin resistance and the malignant progression of non-small cell lung cancer by regulating RILP acetylation levels., PMID:39582290
USP4 depletion-driven RAB7A ubiquitylation impairs autophagosome-lysosome fusion and aggravates periodontitis., PMID:39663592
Loss of PRICKLE1 leads to subfertility, aberrant extracellular matrix and abnormal myometrial architecture in mice., PMID:39679867
RILP cleavage links an inflammatory state to enhanced tau propagation in a cell culture model of Alzheimer's disease., PMID:40137558
Methamphetamine and Methamphetamine-Induced Neuronal Exosomes Modulate the Activity of Rab7a via PTEN to Exert an Influence on the Disordered Autophagic Flux Induced in Neurons., PMID:40141286
AP2A1 activates Rab7 to promote axonal autophagosome transport and slow the progression of Alzheimer's disease., PMID:40490761
For research use only. Not for human or drug use.
