Catalog No.
YHE82701
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Arg599
Predicted molecular weight
70.85 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P51530
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
DNA replication ATP-dependent helicase-like homolog, KIAA0083, hDNA2, DNA2, DNA2L, DNA replication ATP-dependent helicase/nuclease DNA2
DNA2 and FANCM function in two distinctive pathways in disrupting TERRA R-loops and suppressing replication stress at ALT telomeres., PMID:40475582
CTC1-STN1-TEN1 controls DNA break repair pathway choice via DNA end resection blockade., PMID:40403056
LoC-SERS detection platform based on targeted signal anchoring mechanism, high-sensitivity detection of protein biomarkers in precancerous lesions of gastric cancer., PMID:40280078
A naturally integrated RolD-like gene in sweet potato mediates stress-responsive pathways., PMID:40188529
MRN-CtIP, EXO1, and DNA2-WRN/BLM act bidirectionally to process DNA gaps in PARPi-treated cells without strand cleavage., PMID:40127955
Targeting WEE1 kinase as a therapeutic strategy in ATIP3-deficient breast cancers., PMID:40127815
Mitochondrial exonuclease EXOG supports DNA integrity by the removal of single-stranded DNA flaps., PMID:40042814
DNA2 knockout aggravates cerebral ischemia/reperfusion injury by reducing postsynaptic Homer1a., PMID:39846189
Synergistic protection of nascent DNA at stalled forks by MSANTD4 and BRCA1/2-RAD51., PMID:39809895
Dynamic control of RNA-DNA hybrid formation orchestrates DNA2 activation at stalled forks by RNAPII and DDX39A., PMID:39706186
DDX39A resolves replication fork-associated RNA-DNA hybrids to balance fork protection and cleavage for genomic stability maintenance., PMID:39706185
Single-Molecule Visualization of BLM-DNA2-Mediated DNA End Resection Using DNA Curtains., PMID:39704945
Identification and evaluation of plasma exosome RNA biomarkers for non-invasive diagnosis of hepatocellular carcinoma using RNA-seq., PMID:39696145
DNA Conformation-Regulated Hemin Switch for Lab-on-Chip Chemiluminescent Detection of an Antibody Secreted from Hybridoma Cells., PMID:39503400
Microfluidic-SERS sensing system based on dual signal amplification and aptamer for gastric cancer detection., PMID:39400726
Intragenic DNA inversions expand bacterial coding capacity., PMID:39322669
USP50 suppresses alternative RecQ helicase use and deleterious DNA2 activity during replication., PMID:39284827
Simultaneous detection of breast cancer biomarkers HER2 and miRNA-21 based on duplex-specific nuclease signal amplification., PMID:39263860
Promotion of DNA end resection by BRCA1-BARD1 in homologous recombination., PMID:39261729
Mechanism of BRCA1-BARD1 function in DNA end resection and DNA protection., PMID:39261728
Genetic microevolution of clinical Candida auris with reduced Amphotericin B sensitivity in China., PMID:39234778
Replication fork stalling in late S-phase elicits nascent strand degradation by DNA mismatch repair., PMID:39180395
Senataxin RNA/DNA helicase promotes replication restart at co-transcriptional R-loops to prevent MUS81-dependent fork degradation., PMID:39119900
ATM and 53BP1 regulate alternative end joining-mediated V(D)J recombination., PMID:39083600
TRF2-RAP1 represses RAD51-dependent homology-directed telomere repair by promoting BLM-mediated D-loop unwinding and inhibiting BLM-DNA2-dependent 5'-end resection., PMID:39082275
Rad51 determines pathway usage in post-replication repair., PMID:38915629
A novel mutation of DNA2 regulates neuronal cell membrane potential and epileptogenesis., PMID:38802339
Two residues in the DNA binding site of Pif1 helicase are essential for nuclear functions but dispensable for mitochondrial respiratory growth., PMID:38752483
EXO1 and DNA2-mediated ssDNA gap expansion is essential for ATR activation and to maintain viability in BRCA1-deficient cells., PMID:38721777
One-tube B7-H3 detection based on isothermal exponential amplification and dendritic hybridization chain reaction., PMID:38633035
BLM helicase unwinds lagging strand substrates to assemble the ALT telomere damage response., PMID:38593805
Dbf4-dependent kinase promotes cell cycle controlled resection of DNA double-strand breaks and repair by homologous recombination., PMID:38570537
Variants in mitochondrial disease genes are common causes of inherited peripheral neuropathies., PMID:38549004
Identification of clinical characteristics biomarkers for rheumatoid arthritis through targeted DNA methylation sequencing., PMID:38508093
Resection of DNA double-strand breaks activates Mre11-Rad50-Nbs1- and Rad9-Hus1-Rad1-dependent mechanisms that redundantly promote ATR checkpoint activation and end processing in Xenopus egg extracts., PMID:38349040
Targeting DNA2 overcomes metabolic reprogramming in multiple myeloma., PMID:38331987
Rare and common genetic determinants of mitochondrial function determine severity but not risk of amyotrophic lateral sclerosis., PMID:38317984
Loss of Dna2 fidelity results in decreased Exo1-mediated resection at DNA double-strand breaks., PMID:38311177
Mismatch repair protein MLH1 suppresses replicative stress in BRCA2-deficient breast tumors., PMID:38271119
USP50 suppresses alternative RecQ helicase use and deleterious DNA2 activity during replication., PMID:38260523
Target-induced hot spot construction for sensitive and selective surface-enhanced Raman scattering detection of matrix metalloproteinase MMP-9., PMID:38240894
Tandem MutSβ binding to long extruded DNA trinucleotide repeats underpins pathogenic expansions., PMID:38168405
Electrochemical biosensing for E.coli detection based on triple helix DNA inhibition of CRISPR/Cas12a cleavage activity., PMID:38057050
Rothmund-Thomson syndrome, a disorder far from solved., PMID:38021400
Checkpoint phosphorylation sites on budding yeast Rif1 protect nascent DNA from degradation by Sgs1-Dna2., PMID:37956214
MBD1 protects replication fork stability by recruiting PARP1 and controlling transcription-replication conflicts., PMID:37949945
The cancer testes antigen, HORMAD1, limits genomic instability in cancer cells by protecting stalled replication forks., PMID:37838177
DNA2 Nuclease Inhibition Confers Synthetic Lethality in Cancers with Mutant p53 and Synergizes with PARP Inhibitors., PMID:37756561
Proximity hybridization regulated dual-mode ratiometric biosensor for estriol detection in pregnancy serum., PMID:37709442
Structural characterization of human RPA70N association with DNA damage response proteins., PMID:37668474
For research use only. Not for human or drug use.
