Catalog No.
YHK68001
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ser69-Ile579
Predicted molecular weight
60.25 kDa
Nature
Recombinant
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9BYV7
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Beta-carotene dioxygenase 2, BCO2, Beta,beta-carotene 9',10'-oxygenase, B-diox-II, BCDO2
Note
For research use only.
Associations for BCO2, PCSK9, and TR1B1 Polymorphism and Lifestyle Factors with Ischemic Stroke: A Nested Case-Control Study., PMID:31250580
Expression and Characterization of Mammalian Carotenoid Cleavage Dioxygenases., PMID:31745914
Interplay between β-carotene and lipoprotein metabolism at the maternal-fetal barrier., PMID:31863969
Xanthophyll β-Cryptoxanthin Inhibits Highly Refined Carbohydrate Diet-Promoted Hepatocellular Carcinoma Progression in Mice., PMID:31891208
Genetic Basis of De Novo Appearance of Carotenoid Ornamentation in Bare Parts of Canaries., PMID:31930402
Enzymology of vertebrate carotenoid oxygenases., PMID:32035229
Evolutionary aspects and enzymology of metazoan carotenoid cleavage oxygenases., PMID:32061750
Being red, blue and green: the genetic basis of coloration differences in the strawberry poison frog (Oophaga pumilio)., PMID:32293261
Palmitoylation of Metazoan Carotenoid Oxygenases., PMID:32331396
Molecular components affecting ocular carotenoid and retinoid homeostasis., PMID:32339666
A ketocarotenoid-based colour polymorphism in the Sira poison frog Ranitomeya sirensis indicates novel gene interactions underlying aposematic signal variation., PMID:32402099
β-Carotene Oxygenase 1 Activity Modulates Circulating Cholesterol Concentrations in Mice and Humans., PMID:32433733
Astaxanthin-Shifted Gut Microbiota Is Associated with Inflammation and Metabolic Homeostasis in Mice., PMID:32810865
The human mitochondrial enzyme BCO2 exhibits catalytic activity toward carotenoids and apocarotenoids., PMID:32873706
Deficiency of β-carotene oxygenase 2 induces mitochondrial fragmentation and activates the STING-IRF3 pathway in the mouse hypothalamus., PMID:33129969
Pigmentation Genes Show Evidence of Repeated Divergence and Multiple Bouts of Introgression in Setophaga Warblers., PMID:33259789
Ionone Is More than a Violet's Fragrance: A Review., PMID:33321809
β-carotene oxygenase 2 deficiency-triggered mitochondrial oxidative stress promotes low-grade inflammation and metabolic dysfunction., PMID:33453359
The Structural and Biochemical Basis of Apocarotenoid Processing by β-Carotene Oxygenase-2., PMID:33600157
Xanthophylls Modulate Palmitoylation of Mammalian β-Carotene Oxygenase 2., PMID:33803144
Lutein and zeaxanthin reduce A2E and iso-A2E levels and improve visual performance in Abca4-/-/Bco2-/- double knockout mice., PMID:34161819
Insertion of an endogenous Jaagsiekte sheep retrovirus element into the BCO2 - gene abolishes its function and leads to yellow discoloration of adipose tissue in Norwegian Spælsau (Ovis aries)., PMID:34193038
A multispecies BCO2 beak color polymorphism in the Darwin's finch radiation., PMID:34687609
Fenretinide inhibits vitamin A formation from β-carotene and regulates carotenoid levels in mice., PMID:34742949
HDL is the primary transporter for carotenoids from liver to retinal pigment epithelium in transgenic ApoA-I-/-/Bco2-/- mice., PMID:34942193
β-Carotene Oxygenase 2 Genotype Modulates the Impact of Dietary Lycopene on Gene Expression during Early TRAMP Prostate Carcinogenesis., PMID:34964896
Analysis of yellow mutant rainbow trout transcriptomes at different developmental stages reveals dynamic regulation of skin pigmentation genes., PMID:34997156
Aster proteins mediate carotenoid transport in mammalian cells., PMID:35394870
Xanthophyll β-cryptoxanthin treatment inhibits hepatic steatosis without altering vitamin A status in β-carotene 9',10'-oxygenase knockout mice., PMID:35464265
Retinoic acid regulates pyruvate dehydrogenase kinase 4 (Pdk4) to modulate fuel utilization in the adult heart: Insights from wild-type and β-carotene 9',10' oxygenase knockout mice., PMID:36004605
The Effect of the BCO2 Genotype on the Expression of Genes Related to Carotenoid, Retinol, and α-Tocopherol Metabolism in Rabbits Fed a Diet with Aztec Marigold Flower Extract., PMID:36142463
A Computer Simulation Insight into the Formation of Apocarotenoids: Study of the Carotenoid Oxygenases BCO1 and BCO2 and Their Interaction with Putative Substrates., PMID:36431912
The BCO2 Genotype and the Expression of BCO1, BCO2, LRAT, and TTPA Genes in the Adipose Tissue and Brain of Rabbits Fed a Diet with Marigold Flower Extract., PMID:36768627
β-Cryptoxanthin Attenuates Cigarette-Smoke-Induced Lung Lesions in the Absence of Carotenoid Cleavage Enzymes (BCO1/BCO2) in Mice., PMID:36771049
miR-330 targeting BCO2 is involved in carotenoid metabolism to regulate skin pigmentation in rainbow trout (Oncorhynchus mykiss)., PMID:36927381
Prenatal Carotenoid Supplementation With Lutein or Zeaxanthin Ameliorates Oxygen-Induced Retinopathy (OIR) in Bco2-/- Macular Pigment Mice., PMID:37036416
Genetic deletion of Bco2 and Isx establishes a golden mouse model for carotenoid research., PMID:37225015
Lycopene Accumulation in Transgenic Mice Lacking One or Both Carotenoid Cleaving Enzymes., PMID:37269907
Bioavailability and provitamin A activity of neurosporaxanthin in mice., PMID:37864015
Preventive Action of Beta-Carotene against the Indoxyl Sulfate-Induced Renal Dysfunction in Male Adult Zebrafish via Regulations of Mitochondrial Inflammatory and β-Carotene Oxygenase-2 Actions., PMID:37893028
Significant genomic introgression from grey junglefowl (Gallus sonneratii) to domestic chickens (Gallus gallus domesticus)., PMID:38556896
Functional Analysis of β-Carotene Oxygenase 2 (BCO2) Gene in Yesso Scallop (Patinopecten yessoensis)., PMID:38612756
Potential molecular and cellular mechanisms of the effects of cuproptosis-related genes in the cardiomyocytes of patients with diabetic heart failure: a bioinformatics analysis., PMID:38883603
Imaging macular carotenoids and their related proteins in the human retina with confocal resonance Raman and fluorescence microscopy., PMID:39151780
Impact of β-Carotene Enrichment on Carotenoid Composition and Gene Expression in Artemia Metanauplii., PMID:39728457
Distinct pathways for the absorption and metabolism of β-carotene and zeaxanthin in the mouse intestine., PMID:39971162
Unveiling BCO2 function in macular pigment metabolism: Mitochondrial processing and expression in the primate retina., PMID:39978586
Male-Specific Effects of β-Carotene Supplementation on Lipid Metabolism in the Liver and Gonadal Adipose Tissue of Healthy Mice., PMID:40005219
Disentangling the molecular mechanisms underlying yellow body coloration in a soft-shelled turtle., PMID:40091532
Sequence characteristics, evolutionary history and expression pattern of BCO2 in Chinese mitten crab Eriocheir sinensis., PMID:40393191
For research use only. Not for human or drug use.
