Catalog No.
YHD50601
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Leu425
Predicted molecular weight
49.24 kDa
Nature
Recombinant
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P22234
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
SAICAR synthetase, Multifunctional protein ADE2, ADE2, AIRC, PAICS, AIR carboxylase, PAIS
Note
For research use only.
Purine Biosynthesis Enzymes in Hippocampal Neurons., PMID:28866774
Exploration of the diagnostic value and molecular mechanism of miR‑1 in prostate cancer: A study based on meta‑analyses and bioinformatics., PMID:30365107
Chemical Profiling of the Endoplasmic Reticulum Proteome Using Designer Labeling Reagents., PMID:30433779
Development of an Analysis Toolkit, AnalysisFMO, to Visualize Interaction Energies Generated by Fragment Molecular Orbital Calculations., PMID:30517784
Roles of highly expressed PAICS in lung adenocarcinoma., PMID:30641222
PAICS deficiency, a new defect of de novo purine synthesis resulting in multiple congenital anomalies and fatal outcome., PMID:31600779
Combinatorial targeting of MTHFD2 and PAICS in purine synthesis as a novel therapeutic strategy., PMID:31624245
Nwd1 Regulates Neuronal Differentiation and Migration through Purinosome Formation in the Developing Cerebral Cortex., PMID:32344379
The Proteins Interacting with Prmt5 in Medaka (Oryzias latipes) Identified by Yeast Two-Hybridization., PMID:32370700
Potential suppressive functions of microRNA-504 in cervical cancer cells malignant process were achieved by targeting PAICS and regulating EMT., PMID:32417959
PAICS, a De Novo Purine Biosynthetic Enzyme, Is Overexpressed in Pancreatic Cancer and Is Involved in Its Progression., PMID:32422575
Crystal structures of human PAICS reveal substrate and product binding of an emerging cancer target., PMID:32571877
PAICS contributes to gastric carcinogenesis and participates in DNA damage response by interacting with histone deacetylase 1/2., PMID:32632107
Estimation of Hub Genes and Infiltrating Immune Cells in Non-Smoking Females with Lung Adenocarcinoma by Integrated Bioinformatic Analysis., PMID:32669531
Integrated proteomics and metabolomics reveals the comprehensive characterization of antitumor mechanism underlying Shikonin on colon cancer patient-derived xenograft model., PMID:32839531
The CRISPR-Cas9 crATIC HeLa transcriptome: Characterization of a novel cellular model of ATIC deficiency and ZMP accumulation., PMID:32939338
Proteomic Analysis of Atrial Appendages Revealed the Pathophysiological Changes of Atrial Fibrillation., PMID:33041871
Identification of four novel prognosis biomarkers and potential therapeutic drugs for human colorectal cancer by bioinformatics analysis., PMID:33361643
Downregulation of PAICS due to loss of chromosome 4q is associated with poor survival in stage III colorectal cancer., PMID:33596246
PAICS is related to glioma grade and can promote glioma growth and migration., PMID:34173716
Gene Variant of Barrier to Autointegration Factor 2 (Banf2w) Is Concordant with Female Determination in Cichlids., PMID:34209244
Proteome and transcriptome analysis revealed florfenicol via affected drug metabolism and lipid metabolism induce liver injury of broilers., PMID:34293615
In vivo deep network tracing reveals phosphofructokinase-mediated coordination of biosynthetic pathway activity in the myocardium., PMID:34487754
Prediction of Non-canonical Routes for SARS-CoV-2 Infection in Human Placenta Cells., PMID:34820418
Transcriptomic Profile of New Gene Markers Encoding Proteins Responsible for Structure of Porcine Ovarian Granulosa Cells., PMID:34827207
A multiauxotrophic CHO cell line for the rapid isolation of producers of diverse or high levels of recombinant proteins., PMID:35249214
Identification of differentially expressed miRNAs derived from serum exosomes associated with gastric cancer by microarray analysis., PMID:35300960
Combined Targeted and Untargeted Profiling of HeLa Cells Deficient in Purine De Novo Synthesis., PMID:35323684
Multienzyme interactions of the de novo purine biosynthetic protein PAICS facilitate purinosome formation and metabolic channeling., PMID:35331738
Transcriptomic Signatures in Colorectal Cancer Progression., PMID:35490318
GRASP55 regulates the unconventional secretion and aggregation of mutant huntingtin., PMID:35780830
One Stone, Two Birds: A Peptide-Au(I) Infinite Coordination Supermolecule for the Confederate Physical and Biological Radiosensitization in Cancer Radiation Therapy., PMID:36494177
Development of a metabolism-related signature for predicting prognosis, immune infiltration and immunotherapy response in breast cancer., PMID:36628282
CRISPR-Cas9 screen reveals a role of purine synthesis for estrogen receptor α activity and tamoxifen resistance of breast cancer cells., PMID:37172090
PAICS ubiquitination recruits UBAP2 to trigger phase separation for purinosome assembly., PMID:37848033
Mitochondrial subtype MB-G3 contains potential novel biomarkers and therapeutic targets associated with prognosis of medulloblastoma., PMID:37886818
Unanchored Population-Adjusted Indirect Comparison Methods for Time-to-Event Outcomes Using Inverse Odds Weighting, Regression Adjustment, and Doubly Robust Methods With Either Individual Patient or Aggregate Data., PMID:38135212
PAICS/DYRK3 Multienzyme Interactions as Coregulators of Purinosome Formation and Metabolism on Radioresistance in Oral Squamous Cell Carcinoma., PMID:38139175
Genome-wide identification and analysis of epithelial-mesenchymal transition-related RNA-binding proteins and alternative splicing in a human breast cancer cell line., PMID:38783078
Generation of a Rat Monoclonal Antibody for Human PAICS, a de novo Purine Biosynthetic Enzyme., PMID:38836825
Dehydroabietylamine exerts antitumor effects by affecting nucleotide metabolism in gastric cancer., PMID:38869064
Feasibility of Indirect Treatment Comparisons Between Niraparib Plus Abiraterone Acetate and Other First-Line Poly ADP-Ribose Polymerase Inhibitor Treatment Regimens for Patients with BRCA1/2 Mutation-Positive Metastatic Castration-Resistant Prostate Cancer., PMID:38958846
Purinosomes and Purine Metabolism in Mammalian Neural Development: A Review., PMID:38988694
Identification of Potential Biomarkers for Patients with DWI-Negative Ischemic Stroke., PMID:38995420
Role of CENPL, DARS2, and PAICS in determining the prognosis of patients with lung adenocarcinoma., PMID:39507047
Expanding clinical spectrum of PAICS deficiency: Comprehensive analysis of two sibling cases., PMID:39604553
Invasive lobular carcinoma integrated multi-omics analysis reveals silencing of Arginosuccinate synthase and upregulation of nucleotide biosynthesis in tamoxifen resistance., PMID:39868332
GART promotes the proliferation and migration of human non-small cell lung cancer cell lines A549 and H1299 by targeting PAICS-Akt-β-catenin pathway., PMID:40201340
Research advancements in the Use of artificial intelligence for prenatal diagnosis of neural tube defects., PMID:40313675
Phosphoribosylformylglycinamidine Synthase (PFAS) Deficiency: Clinical, Genetic and Metabolic Characterisation of a Novel Defect in Purine de Novo Synthesis., PMID:40421664
For research use only. Not for human or drug use.
