Catalog No.
YHA87101
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Glu121-Thr381
Predicted molecular weight
32.34 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O60296
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
ALS2CR3, Trafficking kinesin-binding protein 2, Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 3 protein, TRAK2, KIAA0549
CircSLC22A3 inhibits the invasion and metastasis of ESCC via the miR-19b-3p/TRAK2 axis and by reducing the stability of m6A-modified ACSBG1 mRNA., PMID:40448098
Clinical implications and molecular mechanism of long noncoding RNA LINC00518 and protein-coding genes in skin cutaneous melanoma by genome‑wide investigation., PMID:39987414
An aggregated mitochondrial distribution in preimplantation embryos disrupts nuclear morphology, function, and developmental potential., PMID:38917013
The amyloid precursor protein and its derived fragments concomitantly contribute to the alterations of mitochondrial transport machinery in Alzheimer's disease., PMID:38806484
Effects of schisandrin B on hypoxia-related cognitive function and protein expression in vascular dementia rats., PMID:38551405
A mammalian-specific Alex3/Gαq protein complex regulates mitochondrial trafficking, dendritic complexity, and neuronal survival., PMID:38320000
Identifying mRNAs Residing in Myelinating Oligodendrocyte Processes as a Basis for Understanding Internode Autonomy., PMID:37109474
Gamma-Aminobutyric Acid Type A Receptor Subunit Pi is a potential chemoresistance regulator in colorectal cancer., PMID:36696022
Mitochondrial adaptor TRAK2 activates and functionally links opposing kinesin and dynein motors., PMID:34321481
GPRASP/ARMCX Protein Family: Potential Involvement in Health and Diseases Revealed by their Novel Interacting Partners., PMID:33267763
Truncated Tau Induces Mitochondrial Transport Failure Through the Impairment of TRAK2 Protein and Bioenergetics Decline in Neuronal Cells., PMID:32848607
Antagomirs targeting miR-142-5p attenuate pilocarpine-induced status epilepticus in mice., PMID:32439493
miR-487b and TRAK2 that form an axis to regulate the aggressiveness of osteosarcoma, are potential therapeutic targets and prognostic biomarkers., PMID:32267991
Myc Regulation of a Mitochondrial Trafficking Network Mediates Tumor Cell Invasion and Metastasis., PMID:31061095
Identification of Miro1 and Miro2 as mitochondrial receptors for myosin XIX., PMID:30111583
Downregulation of splicing regulator RBFOX1 compromises visual depth perception., PMID:30001398
Arf6-driven cell invasion is intrinsically linked to TRAK1-mediated mitochondrial anterograde trafficking to avoid oxidative catastrophe., PMID:29992963
Miro proteins coordinate microtubule- and actin-dependent mitochondrial transport and distribution., PMID:29311115
New splicing variants of mitochondrial Rho GTPase-1 (Miro1) transport peroxisomes., PMID:29222186
Making sense of a seemingly odd connection., PMID:29020393
TRAK2, a novel regulator of ABCA1 expression, cholesterol efflux and HDL biogenesis., PMID:28655204
PINK1 regulates mitochondrial trafficking in dendrites of cortical neurons through mitochondrial PKA., PMID:28556983
TNFα decreases mitochondrial movement in human airway smooth muscle., PMID:28473328
Developmental changes in trak-mediated mitochondrial transport in neurons., PMID:28300646
Huntingtin-associated protein 1: Eutherian adaptation from a TRAK-like protein, conserved gene promoter elements, and localization in the human intestine., PMID:27737633
KIF5A de novo mutation associated with myoclonic seizures and neonatal onset progressive leukoencephalopathy., PMID:27414745
APC binds the Miro/Milton motor complex to stimulate transport of mitochondria to the plasma membrane., PMID:26658612
DISC1-dependent Regulation of Mitochondrial Dynamics Controls the Morphogenesis of Complex Neuronal Dendrites., PMID:26553875
Synergistic action of dendritic mitochondria and creatine kinase maintains ATP homeostasis and actin dynamics in growing neuronal dendrites., PMID:25855183
Localization of the kinesin adaptor proteins trafficking kinesin proteins 1 and 2 in primary cultures of hippocampal pyramidal and cortical neurons., PMID:25653102
Evidence that dendritic mitochondria negatively regulate dendritic branching in pyramidal neurons in the neocortex., PMID:24828647
Neuronal influences are necessary to produce mitochondrial co-localization with glutamate transporters in astrocytes., PMID:24814819
The Armc10/SVH gene: genome context, regulation of mitochondrial dynamics and protection against Aβ-induced mitochondrial fragmentation., PMID:24722288
Delineation of the TRAK binding regions of the kinesin-1 motor proteins., PMID:24161670
Revisiting the TRAK family of proteins as mediators of GABAA receptor trafficking., PMID:24122114
Kinesin-1-syntaphilin coupling mediates activity-dependent regulation of axonal mitochondrial transport., PMID:23857772
TRAK/Milton motor-adaptor proteins steer mitochondrial trafficking to axons and dendrites., PMID:23395375
The Eutherian Armcx genes regulate mitochondrial trafficking in neurons and interact with Miro and Trak2., PMID:22569362
Amplification of thymosin beta 10 and AKAP13 genes in metastatic and aggressive papillary thyroid carcinomas., PMID:22161024
Trafficking kinesin protein (TRAK)-mediated transport of mitochondria in axons of hippocampal neurons., PMID:21454691
N-acetylglucosamine transferase is an integral component of a kinesin-directed mitochondrial trafficking complex., PMID:21034780
Mitofusin 2 is necessary for transport of axonal mitochondria and interacts with the Miro/Milton complex., PMID:20335458
HUMMR, a hypoxia- and HIF-1alpha-inducible protein, alters mitochondrial distribution and transport., PMID:19528298
GTPase dependent recruitment of Grif-1 by Miro1 regulates mitochondrial trafficking in hippocampal neurons., PMID:19103291
GRIF1 binds Hrs and is a new regulator of endosomal trafficking., PMID:17062640
Identification of gamma-aminobutyric acid receptor-interacting factor 1 (TRAK2) as a trafficking factor for the K+ channel Kir2.1., PMID:16895905
Mapping the GRIF-1 binding domain of the kinesin, KIF5C, substantiates a role for GRIF-1 as an adaptor protein in the anterograde trafficking of cargoes., PMID:16835241
GRIF-1-kinesin-1 interactions: a confocal microscopy study., PMID:16417480
GRIF-1 and OIP106, members of a novel gene family of coiled-coil domain proteins: association in vivo and in vitro with kinesin., PMID:15644324
Identification and cloning of a novel family of coiled-coil domain proteins that interact with O-GlcNAc transferase., PMID:12435728
For research use only. Not for human or drug use.
