Catalog No.
YHE16801
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Tyr280-Arg322
Predicted molecular weight
17.71 kDa
Nature
Recombinant
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P36021
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Monocarboxylate transporter 7, MCT 8, SLC16A2, MCT 7, MCT8, X-linked PEST-containing transporter, XPCT, Monocarboxylate transporter 8, Solute carrier family 16 member 2
Note
For research use only.
Helicobacter pylori infection associated DNA methylation in primary gastric cancer significantly correlates with specific molecular and clinicopathological features., PMID:37846801
Functional enrichment analysis of mutated genes in children with hyperthyroidism., PMID:37876543
Proteome Analysis of Thyroid Hormone Transporter Mct8/Oatp1c1-Deficient Mice Reveals Novel Dysregulated Target Molecules Involved in Locomotor Function., PMID:37887331
Neurovascular unit disruption and blood-brain barrier leakage in MCT8 deficiency., PMID:37924081
Allan-Herndon-Dudley syndrome in Hong Kong: Implication for newborn screening., PMID:37925810
Establishment of a 6-signature risk model associated with cellular senescence for predicting the prognosis of breast cancer., PMID:37986376
Generation of iPSC lines with SLC16A2:G401R or SLC16A2 knock out., PMID:38006677
Impact of Early Intervention with Triiodothyroacetic Acid on Peripheral and Neurodevelopmental Findings in a Boy with MCT8 Deficiency., PMID:38054413
Regulation of Thyroid Hormone Gatekeepers by Thyrotropin in Tanycytes., PMID:38115594
Screening for endocrine disrupting chemicals inhibiting monocarboxylate 8 (MCT8) transporter facilitated thyroid hormone transport using a modified nonradioactive assay., PMID:38151217
Novel SLC16A2 Gene Mutation: A Rare Case of Delayed Myelination with Dysthyroidism,v Allan-Herndon-Dudley Syndrome., PMID:38174482
Genome-Wide Association Analysis of Heat Tolerance in F2 Progeny from the Hybridization between Two Congeneric Oyster Species., PMID:38203295
Late diagnosis of the X-linked MCT8 deficiency (Allan-Herndon-Dudley syndrome) in a teenage girl with primary ovarian insufficiency., PMID:38345890
The dynamic landscape of chromatin accessibility and active regulatory elements in the mediobasal hypothalamus influences the seasonal activation of the reproductive axis in the male quail under long light exposure., PMID:38373887
Impaired T3 uptake and action in MCT8-deficient cerebral organoids underlie Allan-Herndon-Dudley syndrome., PMID:38376950
The Differential Effect of a Shortage of Thyroid Hormone Compared with Knockout of Thyroid Hormone Transporters Mct8 and Mct10 on Murine Macrophage Polarization., PMID:38396788
Movement Disorder Perspectives on Monocarboxylate 8 Deficiency: A Case Series of 3 Colombian Patients with Allan-Herndon-Dudley Syndrome., PMID:38454300
Glycerol Phenylbutyrate Treatment of 2 Patients With Monocarboxylate Transporter 8 Deficiency., PMID:38469646
Spatiotemporal expression of thyroid hormone transporter MCT8 and THRA mRNA in human cerebral organoids recapitulating first trimester cortex development., PMID:38654093
Identification of Iodotyrosines as Novel Substrates for the Thyroid Hormone Transporter MCT8., PMID:38661522
Phenylbutyrate Treatment in a Boy With MCT8 Deficiency: Improvement of Thyroid Function Tests and Possible Hepatotoxicity., PMID:38781537
Identification of Human TRIAC Transmembrane Transporters., PMID:38801167
3,3',5-Triiodothyroacetic Acid Transporters., PMID:38836423
Combined deletion of Mct8 and Dio2 impairs SVZ neurogliogenesis and olfactory function in adult mice., PMID:38901782
A Highly Selective Fluorescent Probe for Monitoring the Thyroid Hormone Transporter Activity in Mammalian Cells., PMID:38995511
Cone photoreceptor differentiation regulated by thyroid hormone transporter MCT8 in the retinal pigment epithelium., PMID:39018199
Identification of a novel nonsense SLC16A2 gene mutation in an infant with severe neurologic phenotype: A case report., PMID:39029020
Melanocortin-4 Receptor PLC Activation Is Modulated by an Interaction with the Monocarboxylate Transporter 8., PMID:39062808
Defective thyroid hormone transport to the brain leads to astroglial alterations., PMID:39097035
Normal Values for the fT3/fT4 Ratio: Centile Charts (0-29 Years) and Their Application for the Differential Diagnosis of Children with Developmental Delay., PMID:39201272
Combined Levothyroxine and Propylthiouracil Treatment in Children with Monocarboxylate Transporter 8 Deficiency: A Multicenter Case Series of 12 Patients., PMID:39283825
Toward a treatment for thyroid hormone transporter MCT8 deficiency - achievements and challenges., PMID:39485732
Magnetic Resonance Imaging Techniques for Investigating the MCT8-Deficient Brain in Murine Disease Models., PMID:39579316
Clinical and genetic characteristics of patients with monocarboxylate transporter-8 deficiency: a multicentre retrospective study., PMID:39699593
Sciatic nerve analysis in thyroid hormone transporters Mct8 and Oatp1c1 knockout mice., PMID:39812369
The interactions between monocarboxylate transporter genes MCT1, MCT2, and MCT4 and the kinetics of blood lactate production and removal after high-intensity efforts in elite males: a cross-sectional study., PMID:39934699
Maternal per- and polyfluoroalkyl substance concentrations and placental DNA methylation of thyroid hormone-related genes., PMID:39947079
Increased seizure susceptibility in thyroid hormone transporter Mct8/Oatp1c1 knockout mice is associated with altered neurotransmitter systems development., PMID:39986448
Identification of a novel non-coding deletion in Allan-Herndon-Dudley syndrome by long-read HiFi genome sequencing., PMID:40033291
Mapping variants in thyroid hormone transporter MCT8 to disease severity by genomic, phenotypic, functional, structural and deep learning integration., PMID:40075072
Patients with Allan-Herndon-Dudley Syndrome (MCT8 Deficiency) Display Symptoms of Parkinsonism in Childhood and Respond to Levodopa/Carbidopa Treatment., PMID:40088079
Cryo-EM structure of the human monocarboxylate transporter 10., PMID:40112803
Correction of the Allan-Herndon-Dudley syndrome-causing SLC16A2 mutation G401R in a patient derived hiPSC line., PMID:40120557
Allan-Herndon-Dudley Syndrome., PMID:40131620
Structural insights into thyroid hormone transporter MCT8., PMID:40140416
Development of a breast cancer invasion score to predict tumor aggressiveness and prognosis via PI3K/AKT/mTOR pathway analysis., PMID:40204712
Genetic aetiologies in relation to response to the ketogenic diet in 226 children with epilepsy., PMID:40290421
Generation of two human induced pluripotent stem cell lines from Allan-Herndon-Dudley syndrome (AHDS) patients with SLC16A2:G401R or SLC16A2: H192R mutation., PMID:40311327
Molecular mechanism of thyroxine transport by monocarboxylate transporters., PMID:40368961
Pathogenic MCT8V235L creates a steric clash that is alleviated by a compensating mutation of MCT8F285A., PMID:40396883
For research use only. Not for human or drug use.
