Catalog No.
YHE68701
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Ser201
Predicted molecular weight
25.00 kDa
Nature
Recombinant
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P49721
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Multicatalytic endopeptidase complex subunit C7-I, Macropain subunit C7-I, Proteasome component C7-I, Proteasome subunit beta type-2, PSMB2
Note
For research use only.
Intermediates in the formation of mouse 20S proteasomes: implications for the assembly of precursor beta subunits., PMID:9311996
Genetic relationships of the genes encoding the human proteasome beta subunits and the proteasome PA28 complex., PMID:9344661
The complete primary structure of mouse 20S proteasomes., PMID:10436176
Differential expression of genes encoding constitutive and inducible 20S proteasomal core subunits in the testis and epididymis of theophylline- or 1,3-dinitrobenzene-exposed rats., PMID:16988215
Comparative analysis of transcriptional profiling of CD3+, CD4+ and CD8+ T cells identifies novel immune response players in T-cell activation., PMID:18485203
A new tick Kunitz type inhibitor, Amblyomin-X, induces tumor cell death by modulating genes related to the cell cycle and targeting the ubiquitin-proteasome system., PMID:20570593
Proteome alterations of cortex and hippocampus tissues in mice subjected to vitamin A depletion., PMID:21190828
RNAi screen of the druggable genome identifies modulators of proteasome inhibitor sensitivity in myeloma including CDK5., PMID:21289309
The over-expression of the β2 catalytic subunit of the proteasome decreases homologous recombination and impairs DNA double-strand break repair in human cells., PMID:21660142
AGR2 is a novel surface antigen that promotes the dissemination of pancreatic cancer cells through regulation of cathepsins B and D., PMID:21948970
Modulation of autophagy and ubiquitin-proteasome pathways during ultra-endurance running., PMID:22345427
Dopaminergic therapies modulate the T-CELL proteome of patients with Parkinson's disease., PMID:22815142
The homeodomain transcription factor Hoxa2 interacts with and promotes the proteasomal degradation of the E3 ubiquitin protein ligase RCHY1., PMID:24244684
TLR4 mediates the impairment of ubiquitin-proteasome and autophagy-lysosome pathways induced by ethanol treatment in brain., PMID:24556681
Chronic schizophrenia is associated with over-expression of the interleukin-2 receptor gamma gene., PMID:24713359
Apigenin manipulates the ubiquitin-proteasome system to rescue estrogen receptor-β from degradation and induce apoptosis in prostate cancer cells., PMID:25408199
Gene expression profiling identifies the novel role of immunoproteasome in doxorubicin-induced cardiotoxicity., PMID:25896364
Functional analysis of keratinocyte and fibroblast gene expression in skin and keloid scar tissue based on deviation analysis of dynamic capabilities., PMID:28101157
Inhibition of the Proteasome β2 Site Sensitizes Triple-Negative Breast Cancer Cells to β5 Inhibitors and Suppresses Nrf1 Activation., PMID:28132893
Elevated transcriptional levels of aldolase A (ALDOA) associates with cell cycle-related genes in patients with NSCLC and several solid tumors., PMID:28191039
Quercetin Prevents In Vivo and In Vitro Myocardial Hypertrophy Through the Proteasome-GSK-3 Pathway., PMID:29435775
NUDT21 negatively regulates PSMB2 and CXXC5 by alternative polyadenylation and contributes to hepatocellular carcinoma suppression., PMID:29780166
Structure-Based Design of Inhibitors Selective for Human Proteasome β2c or β2i Subunits., PMID:30657666
Upregulation of Proteolytic Pathways and Altered Protein Biosynthesis Underlie Retinal Pathology in a Mouse Model of Alzheimer's Disease., PMID:30707393
Host-Viral Interactions Revealed among Shared Transcriptomics Signatures of ARDS and Thrombosis: A Clue into COVID-19 Pathogenesis., PMID:33354650
Expression of immunoproteasome subunits in the brains of Toxoplasma gondii-infected mice., PMID:34547302
Effectiveness of bortezomib and temozolomide for eradication of recurrent human glioblastoma cells, resistant to radiation., PMID:34689859
Shared Molecular Mechanisms between Atherosclerosis and Periodontitis by Analyzing the Transcriptomic Alterations of Peripheral Blood Monocytes., PMID:34899963
Exploration of a Novel Prognostic Nomogram and Diagnostic Biomarkers Based on the Activity Variations of Hallmark Gene Sets in Hepatocellular Carcinoma., PMID:35359370
Bioinformatic Analysis Identifying PSMB 1/2/3/4/6/8/9/10 as Prognostic Indicators in Clear Cell Renal Cell Carcinoma., PMID:35693739
Genome-Wide Association Study of Egg-Laying Traits and Egg Quality in LingKun Chickens., PMID:35795788
PSMB5 overexpression is correlated with tumor proliferation and poor prognosis in hepatocellular carcinoma., PMID:36062301
PSMB2 knockdown suppressed proteasome activity and cell proliferation, promoted apoptosis, and blocked NRF1 activation in gastric cancer cells., PMID:36110152
Luteolin Attenuates Diabetic Myocardial Hypertrophy by Inhibiting Proteasome Activity., PMID:36423586
Genome-wide siRNA screens identify RBBP9 function as a potential target in Fanconi anaemia-deficient head-and-neck squamous cell carcinoma., PMID:36639418
Optimized whole-genome CRISPR interference screens identify ARID1A-dependent growth regulators in human induced pluripotent stem cells., PMID:37028423
Cathelicidin Antimicrobial Peptide Acts as a Tumor Suppressor in Hepatocellular Carcinoma., PMID:37958632
Zonisamide attenuates pressure overload-induced myocardial hypertrophy in mice through proteasome inhibition., PMID:38097716
[Bioinformatics analysis of primary biliary cholangitis key genes and molecular mechanisms]., PMID:38238956
PSMB2 plays an oncogenic role in glioma and correlates to the immune microenvironment., PMID:38467767
Comparative proteomic analyses to investigate premature browning in high‑oxygen modified atmosphere packaged beef patties., PMID:38876067
The Proteomic Analysis of Chronic Migraine Exosomes Reveals Disease Patterns and Potential Biomarkers., PMID:39066974
Sevoflurane Mediates LINC00339/miR-671-5p/PSMB2 Axis to Improve Cardiomyocytes Against Hypoxia/Reoxygenation Injury., PMID:40143635
For research use only. Not for human or drug use.
