Catalog No.
YHK57801
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Gly80-Trp368
Predicted molecular weight
35.80 kDa
Nature
Recombinant
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9Y2S7
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Polymerase delta-interacting protein 2, p38, 38 kDa DNA polymerase delta interaction protein, POLDIP2, PDIP38, POLD4
Note
For research use only.
High Salt Enhances Reactive Oxygen Species and Angiotensin II Contractions of Glomerular Afferent Arterioles From Mice With Reduced Renal Mass., PMID:30354808
Poldip2 deficiency protects against lung edema and vascular inflammation in a model of acute respiratory distress syndrome., PMID:30622219
Polymerase-δ-interacting protein 2 activates the RhoGEF epithelial cell transforming sequence 2 in vascular smooth muscle cells., PMID:30726115
PDIP38/PolDIP2 controls the DNA damage tolerance pathways by increasing the relative usage of translesion DNA synthesis over template switching., PMID:30840704
Hepatic deficiency of Poldip2 in type 2 diabetes dampens lipid and glucose homeostasis., PMID:31351995
Matrine pre-treatment suppresses AGEs- induced HCSMCs fibrotic responses by regulating Poldip2/mTOR pathway., PMID:31634459
Mitochondrial Protein Poldip2 (Polymerase Delta Interacting Protein 2) Controls Vascular Smooth Muscle Differentiated Phenotype by O-Linked GlcNAc (N-Acetylglucosamine) Transferase-Dependent Inhibition of a Ubiquitin Proteasome System., PMID:31656131
Poldip2 mediates blood-brain barrier disruption in a model of sepsis-associated encephalopathy., PMID:31779628
A Multifunctional Protein PolDIP2 in DNA Translesion Synthesis., PMID:32383114
The Mouse Heart Mitochondria N Terminome Provides Insights into ClpXP-Mediated Proteolysis., PMID:32467259
Poldip2 mediates blood-brain barrier disruption and cerebral edema by inducing AQP4 polarity loss in mouse bacterial meningitis model., PMID:32790044
Polymerase delta-interacting protein 38 (PDIP38) modulates the stability and activity of the mitochondrial AAA+ protease CLPXP., PMID:33159171
Strand Displacement Activity of PrimPol., PMID:33261049
[PolDIP2 regulates mitochondrial functioning and cellular metabolism]., PMID:33492225
A unique arginine cluster in PolDIP2 enhances nucleotide binding and DNA synthesis by PrimPol., PMID:33533925
Poldip2 controls leukocyte infiltration into the ischemic brain by regulating focal adhesion kinase-mediated VCAM-1 induction., PMID:33692398
Crystal structure and molecular dynamics of human POLDIP2, a multifaceted adaptor protein in metabolism and genome stability., PMID:33884680
Human Polymerase δ-Interacting Protein 2 (PolDIP2) Inhibits the Formation of Human Tau Oligomers and Fibrils., PMID:34071254
MIR31HG regulates the proliferation, migration and invasion of breast cancer by regulating the expression of POLDIP2., PMID:34076993
Mass Spectrometry-Based Proteomic Discovery of Prognostic Biomarkers in Adrenal Cortical Carcinoma., PMID:34359790
Translesion activity of PrimPol on DNA with cisplatin and DNA-protein cross-links., PMID:34475447
Endothelial Poldip2 regulates sepsis-induced lung injury via Rho pathway activation., PMID:34528082
Characterization of Poldip2 knockout mice: Avoiding incorrect gene targeting., PMID:34928942
Inactivity of Peptidase ClpP Causes Primary Accumulation of Mitochondrial Disaggregase ClpX with Its Interacting Nucleoid Proteins, and of mtDNA., PMID:34943861
Poldip2/Nox4 Mediates Lipopolysaccharide-Induced Oxidative Stress and Inflammation in Human Lung Epithelial Cells., PMID:35140544
MicroRNA 148a Suppresses Tuberculous Fibrosis by Targeting NOX4 and POLDIP2., PMID:35328424
Myeloid Poldip2 Contributes to the Development of Pulmonary Inflammation by Regulating Neutrophil Adhesion in a Murine Model of Acute Respiratory Distress Syndrome., PMID:35535614
The genomic profile of double primary secretory breast carcinoma in one patient provides evidence for the treatment of such carcinoma: A case report., PMID:35810566
The Bacterial ClpXP-ClpB Family Is Enriched with RNA-Binding Protein Complexes., PMID:35954215
Capsaicin ameliorates diabetic retinopathy by inhibiting poldip2-induced oxidative stress., PMID:36088760
Poldip2 knockdown protects against lipopolysaccharide-induced acute lung injury via Nox4/Nrf2/NF-κB signaling pathway., PMID:36120334
ZEB1 regulates bone metabolism in osteoporotic rats through inducing POLDIP2 transcription., PMID:36123704
Translesion Synthesis across the N2-Ethyl-deoxyguanosine Adduct by Human PrimPol., PMID:36318733
The polymerase δ-interacting protein family and their emerging roles in diseases., PMID:36425112
Metabolic regulation of the proteasome under hypoxia by Poldip2 controls fibrotic signaling in vascular smooth muscle cells., PMID:36596387
Human papillomavirus E6/E7 oncoproteins promote radiotherapy-mediated tumor suppression by globally hijacking host DNA damage repair., PMID:36793865
Knockout of AMD-associated gene POLDIP2 reduces mitochondrial superoxide in human retinal pigment epithelial cells., PMID:36795578
New insights in the molecular regulation of the NADPH oxidase 2 activity: Negative modulation by Poldip2., PMID:36828293
mRNA markers associated with malignant pleural effusion., PMID:37095178
Therapeutic targets for endometriosis: Genome-wide Mendelian randomization and colocalization analyses., PMID:37931855
Identifying risk loci for FTD and shared genetic component with ALS: A large-scale multitrait association analysis., PMID:37979250
The mitochondrial protease ClpP is a druggable target that controls VSMC phenotype by a SIRT1-dependent mechanism., PMID:38823208
Overexpressed Poldip2 Incurs Retinal Fibrosis via the TGF-β1/SMAD3 Signaling Pathway in Diabetic Retinopathy., PMID:38968428
An adaptor for feedback regulation of heme biosynthesis by the mitochondrial protease CLPXP., PMID:39005287
Obtusin ameliorates diabetic retinopathy by inhibiting oxidative stress and inflammation., PMID:39488807
Old Passengers as New Drivers: Chromosomal Passenger Proteins Engage in Translesion Synthesis., PMID:39513910
Polymerase delta-interacting protein 2 mediates brain vascular permeability by regulating ROS-mediated ZO-1 phosphorylation and localization at the interendothelial border., PMID:39773189
Poldip2 promotes mtDNA elimination during Drosophila spermatogenesis to ensure maternal inheritance., PMID:39934413
Mitochondrial DNA removal is essential for sperm development and activity., PMID:39934414
Poldip2 Aggravates inflammation in diabetic retinopathy by impairing mitophagy via the AMPK/ULK1/Pink1 pathway., PMID:40320136
For research use only. Not for human or drug use.
