Catalog No.
YHH06401
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ser182-His338
Predicted molecular weight
20.15 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q15319
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Brn-3C, Brain-3C, Brain-specific homeobox/POU domain protein 3C, POU4F3, BRN3C, POU domain, class 4, transcription factor 3
Functional Correlation of Two Novel Nonsense POU4F3 Mutations Causing Late-Onset Progressive Nonsyndromic Hearing Loss in DFNA15 Families., PMID:40364746
A gene regulatory network for specification and morphogenesis of a Mauthner Cell homolog in non-vertebrate chordates., PMID:40096956
Conditional Overexpression of Serpine2 Promotes Hair Cell Regeneration from Lgr5+ Progenitors in the Neonatal Mouse Cochlea., PMID:40091489
Co-overexpression of Atoh1, Pou4f3, and Gfi1 enhances the transdifferentiation of supporting cells into hair cells in the neonatal mouse utricle., PMID:39884380
Extent of genetic and epigenetic factor reprogramming via a single viral vector construct in deaf adult mice., PMID:39848037
Oligogenic effect is associated with the clinical heterogeneity of autosomal dominant deafness-15., PMID:39809934
Conditional Overexpression of Net1 Enhances the Trans-Differentiation of Lgr5+ Progenitors into Hair Cells in the Neonatal Mouse Cochlea., PMID:39675772
Reprogramming with Atoh1, Gfi1, and Pou4f3 promotes hair cell regeneration in the adult organ of Corti., PMID:39411090
POU4F3 Is a Sensitive and Specific Marker of Merkel Cell Carcinoma., PMID:39341281
AAV-mediated Gene Cocktails Enhance Supporting Cell Reprogramming and Hair Cell Regeneration., PMID:38810137
Sensorineural correlates of failed functional recovery after natural regeneration of vestibular hair cells in adult mice., PMID:38523617
Deciphering the genetic interactions between Pou4f3, Gfi1, and Rbm24 in maintaining mouse cochlear hair cell survival., PMID:38483314
Expression of Atoh1, Gfi1, and Pou4f3 in the mature cochlea reprograms nonsensory cells into hair cells., PMID:38266052
Combinatorial Atoh1, Gfi1, Pou4f3, and Six1 gene transfer induces hair cell regeneration in the flat epithelium of mature guinea pigs., PMID:38103445
Cochlear organoids reveal transcriptional programs of postnatal hair cell differentiation from supporting cells., PMID:37952154
Gene mutations as a non-invasive measure of adult cochlear implant performance: Variable outcomes in patients with select TMPRSS3 mutations., PMID:37713394
Ramifications of POU4F3 variants associated with autosomal dominant hearing loss in various molecular aspects., PMID:37537203
Highly variable hearing loss due to POU4F3 (c.37del) is revealed by longitudinal, frequency specific analyses., PMID:37072551
Cellular reprogramming with ATOH1, GFI1, and POU4F3 implicate epigenetic changes and cell-cell signaling as obstacles to hair cell regeneration in mature mammals., PMID:36445327
Knockdown and mutation of Pou4f3 gene mutation promotes pyroptosis of cochleae in cisplatin-induced deafness mice by NLRP3/caspase-3/GSDME pathway., PMID:36341876
Critical roles of FGF, RA, and WNT signalling in the development of the human otic placode and subsequent lineages in a dish., PMID:35620640
Repair of surviving hair cells in the damaged mouse utricle., PMID:35380897
Small activating RNA activation of ATOH1 promotes regeneration of human inner ear hair cells., PMID:35246011
Semi-automated quantification of hair cells in the mature mouse utricle., PMID:35081508
POU4F3 Acts as a Tumor Suppressor in Lung Adenocarcinoma via the Endoplasmic Reticulum Stress Signaling Pathway., PMID:35069902
Genetic etiology of non-syndromic hearing loss in Europe., PMID:35044523
A Screen of Autophagy Compounds Implicates the Proteasome in Mammalian Aminoglycoside-Induced Hair Cell Damage., PMID:34765606
The cell adhesion molecule Sdk1 shapes assembly of a retinal circuit that detects localized edges., PMID:34545809
Norrie disease protein is essential for cochlear hair cell maturation., PMID:34544869
Hearing Impairment with Monoallelic GJB2 Variants: A GJB2 Cause or Non-GJB2 Cause?, PMID:34325055
A Genome-First Approach to Rare Variants in Dominant Postlingual Hearing Loss Genes in a Large Adult Population., PMID:34281439
POU4F3 pioneer activity enables ATOH1 to drive diverse mechanoreceptor differentiation through a feed-forward epigenetic mechanism., PMID:34266958
A Missense POU4F3 Variant Associated with Autosomal Dominant Midfrequency Hearing Loss Alters Subnuclear Localization and Transcriptional Capabilities., PMID:34250087
Generation of mature and functional hair cells by co-expression of Gfi1, Pou4f3, and Atoh1 in the postnatal mouse cochlea., PMID:33882317
Alpha synuclein (SNCA) rs7684318 variant contributes to Parkinson's disease risk by altering transcription factor binding related with Notch and Wnt signaling., PMID:33705925
Dynamic patterns of YAP1 expression and cellular localization in the developing and injured utricle., PMID:33495483
Combinatorial Atoh1 and Gfi1 induction enhances hair cell regeneration in the adult cochlea., PMID:33293609
Effects of cochlear hair cell ablation on spatial learning/memory., PMID:33244175
Identification of retinal ganglion cell types and brain nuclei expressing the transcription factor Brn3c/Pou4f3 using a Cre recombinase knock-in allele., PMID:33135183
Aldh inhibitor restores auditory function in a mouse model of human deafness., PMID:32970669
GFI1 functions to repress neuronal gene expression in the developing inner ear hair cells., PMID:32917668
The role of gfi1.2 in the development of zebrafish inner ear., PMID:32814237
Four Novel Variants in POU4F3 Cause Autosomal Dominant Nonsyndromic Hearing Loss., PMID:32684921
Generation of inner ear hair cells by direct lineage conversion of primary somatic cells., PMID:32602462
Identification of two novel mutations in POU4F3 gene associated with autosomal dominant hearing loss in Chinese families., PMID:32390314
Brn3/POU-IV-type POU homeobox genes-Paradigmatic regulators of neuronal identity across phylogeny., PMID:32012462
Dynamic changes in cis-regulatory occupancy by Six1 and its cooperative interactions with distinct cofactors drive lineage-specific gene expression programs during progressive differentiation of the auditory sensory epithelium., PMID:31956913
The emergence of transcriptional identity in somatosensory neurons., PMID:31915380
Pou4f3 gene mutation promotes autophagy and apoptosis of cochlear hair cells in cisplatin-induced deafness mice., PMID:31830441
For research use only. Not for human or drug use.
