Catalog No.
YHH87801
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Thr125
Predicted molecular weight
15.58 kDa
Nature
Recombinant
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q53FT3
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
HIKESHI, Protein Hikeshi, C11orf73
Note
For research use only.
Hikeshi, a nuclear import carrier for Hsp70s, protects cells from heat shock-induced nuclear damage., PMID:22541429
Heat-shock stress activates a novel nuclear import pathway mediated by Hikeshi., PMID:22895094
The Schizosaccharomyces pombe Hikeshi/Opi10 protein has similar biochemical functions to its human homolog but acts in different physiological contexts., PMID:24768994
Nucleocytoplasmic transport under stress conditions and its role in HSP70 chaperone systems., PMID:24797038
Functional analysis of the Hikeshi-like protein and its interaction with HSP70 in Arabidopsis., PMID:24942879
Crystallization and preliminary X-ray crystallographic study of human Hikeshi, a new nuclear transport receptor for Hsp70., PMID:25484218
Structural and functional analysis of Hikeshi, a new nuclear transport receptor of Hsp70s., PMID:25760597
Structural Biology and Regulation of Protein Import into the Nucleus., PMID:26523678
Leukoencephalopathy and early death associated with an Ashkenazi-Jewish founder mutation in the Hikeshi gene., PMID:26545878
[Hikeshi: Nucleocytoplasmic protein transport under stress conditions]., PMID:26571552
Absence of Hikeshi, a nuclear transporter for heat-shock protein HSP70, causes infantile hypomyelinating leukoencephalopathy., PMID:28000699
Heat shock-induced HIKESHI protects cell viability via nuclear translocation of heat shock protein 70., PMID:28731175
Hikeshi modulates the proteotoxic stress response in human cells: Implication for the importance of the nuclear function of HSP70s., PMID:28980748
Heat stress-induced nuclear transport mediated by Hikeshi confers nuclear function of Hsp70s., PMID:29490261
Nuclear Accumulation of HSP70 in Mouse Skeletal Muscles in Response to Heat Stress, Aging, and Unloading With or Without Reloading., PMID:30619453
Glucose-Regulated HLP1 Acts as a Key Molecule in Governing Thermomemory., PMID:30890662
Alterations of Brain Quantitative Proteomics Profiling Revealed the Molecular Mechanisms of Diosgenin against Cerebral Ischemia Reperfusion Effects., PMID:31940440
HIKESHI silencing can enhance mild hyperthermia sensitivity in human oral squamous cell carcinoma HSC‑3 cells., PMID:32377716
The Infantile Leukoencephalopathy-Associated Mutation of C11ORF73/HIKESHI Proteins Generates de novo Interactive Activity with Filamin A, Inhibiting Oligodendroglial Cell Morphological Differentiation., PMID:33535532
Further Delineation of the Clinical and Pathologic Features of HIKESHI-Related Hypomyelinating Leukodystrophy., PMID:34111619
Diosgenin revealed potential effect against cerebral ischemia reperfusion through HIKESHI/HSP70/NF-κB anti-inflammatory axis., PMID:35217435
Combination therapy with radiation and hyperthermia-induced clinical complete response of small cell carcinoma of prostate., PMID:35252794
Lack of Hikeshi activates HSF1 activity under normal conditions and disturbs the heat-shock response., PMID:35580988
Role of HIKESHI on Hyperthermia for Castration-Resistant Prostate Cancer and Application of a Novel Magnetic Nanoparticle with Carbon Nanohorn for Magnetic Hyperthermia., PMID:36839948
Nuclear import carrier Hikeshi cooperates with HSP70 to promote murine oligodendrocyte differentiation and CNS myelination., PMID:37865085
Defective oligodendrocyte differentiation by hypomyelinating leukodystrophy 13 (HLD13)-associated mutation of Hikeshi., PMID:37965292
Genome-Wide Admixture and Association Study of Serum Selenium Deficiency to Identify Genetic Variants Indirectly Linked to Selenium Regulation in Brazilian Adults., PMID:38892560
A novel missense variant in HIKESHI: Clinical phenotype, in vitro functional testing, and potential for gene therapy., PMID:38922739
The interaction between the import carrier Hikeshi and HSP70 is modulated by heat, facilitating the nuclear import of HSP70 under heat stress conditions., PMID:38987995
Thermal Stress and Nuclear Transport., PMID:39289274
Functional analysis of Hikeshi reveals physiological significance of nuclear Hsp70., PMID:39317134
For research use only. Not for human or drug use.
