Catalog No.
YHK53301
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Gly96-Thr141
Predicted molecular weight
17.31 kDa
Nature
Recombinant
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q8IY63
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Angiomotin-like protein 1, AMOTL1
Note
For research use only.
MiR-124 represses vasculogenic mimicry and cell motility by targeting amotL1 in cervical cancer cells., PMID:25218344
Energy stress regulates hippo-YAP signaling involving AMPK-mediated regulation of angiomotin-like 1 protein., PMID:25373897
Exosome-mediated microRNA signaling from breast cancer cells is altered by the anti-angiogenesis agent docosahexaenoic acid (DHA)., PMID:26178901
AMOTL1 Promotes Breast Cancer Progression and Is Antagonized by Merlin., PMID:26806348
Powerful and Adaptive Testing for Multi-trait and Multi-SNP Associations with GWAS and Sequencing Data., PMID:27075728
Mitigation of tight junction protein dysfunction in lung microvascular endothelial cells with pitavastatin., PMID:27179426
Angiomotin like-1 is a novel component of the N-cadherin complex affecting endothelial/pericyte interaction in normal and tumor angiogenesis., PMID:27464479
The endothelial E3 ligase HECW2 promotes endothelial cell junctions by increasing AMOTL1 protein stability via K63-linked ubiquitination., PMID:27498087
Amotl1 mediates sequestration of the Hippo effector Yap1 downstream of Fat4 to restrict heart growth., PMID:28239148
A circular RNA promotes tumorigenesis by inducing c-myc nuclear translocation., PMID:28622299
Angiomotin Family Members: Oncogenes or Tumor Suppressors?, PMID:28656002
The Circular RNA Interacts with STAT3, Increasing Its Nuclear Translocation and Wound Repair by Modulating Dnmt3a and miR-17 Function., PMID:28676341
Tankyrase inhibitors suppress hepatocellular carcinoma cell growth via modulating the Hippo cascade., PMID:28877210
A Circular RNA Binds To and Activates AKT Phosphorylation and Nuclear Localization Reducing Apoptosis and Enhancing Cardiac Repair., PMID:29109781
Human Papillomavirus E6 interaction with cellular PDZ domain proteins modulates YAP nuclear localization., PMID:29346075
A missense mutation in TRAPPC6A leads to build-up of the protein, in patients with a neurodevelopmental syndrome and dysmorphic features., PMID:29391579
The physiological role of Motin family and its dysregulation in tumorigenesis., PMID:29650031
Angiomotins stimulate LATS kinase autophosphorylation and act as scaffolds that promote Hippo signaling., PMID:30266805
Using human sequencing to guide craniofacial research., PMID:30375152
Dysregulation of p53-RBM25-mediated circAMOTL1L biogenesis contributes to prostate cancer progression through the circAMOTL1L-miR-193a-5p-Pcdha pathway., PMID:30531834
Oxyquinoline-Dependent Changes in Claudin-Encoding Genes Contribute to Impairment of the Barrier Function of the Trophoblast Monolayer., PMID:30627900
Angiomotin-Like 1 Links Paramyxovirus M Proteins to NEDD4 Family Ubiquitin Ligases., PMID:30708959
AMOTL1 enhances YAP1 stability and promotes YAP1-driven gastric oncogenesis., PMID:32313226
De novo variant in AMOTL1 in infant with cleft lip and palate, imperforate anus and dysmorphic features., PMID:33026150
NEDD4L-mediated Merlin ubiquitination facilitates Hippo pathway activation., PMID:33058421
Abnormally increased DNA methylation in chorionic tissue might play an important role in development of ectopic pregnancy., PMID:34215268
Angiomotin-like 1 plays a tumor-promoting role in glioma by enhancing the activation of YAP1 signaling., PMID:34480788
The podocyte-specific knockout of palladin in mice with a 129 genetic background affects podocyte morphology and the expression of palladin interacting proteins., PMID:34879092
Fragment-based exploration of the 14-3-3/Amot-p130 interface., PMID:35036934
Multivalent Angiomotin-like 1 and Yes-associated protein form a dynamic complex., PMID:35481651
Game-theoretic link relevance indexing on genome-wide expression dataset identifies putative salient genes with potential etiological and diapeutics role in colorectal cancer., PMID:35927308
Estrogen Regulates the Expression and Localization of YAP in the Uterus of Mice., PMID:36077170
Clinical report: Chronic liver dysfunction in an individual with an AMOTL1 variant., PMID:36116699
DAR 16-II Primes Endothelial Cells for Angiogenesis Improving Bone Ingrowth in 3D-Printed BCP Scaffolds and Regeneration of Critically Sized Bone Defects., PMID:36358970
The chaperone-assisted selective autophagy complex dynamics and dysfunctions., PMID:36594740
A mutational hotspot in AMOTL1 defines a new syndrome of orofacial clefting, cardiac anomalies, and tall stature., PMID:36751037
CircAMOTL1 RNA and AMOTL1 Protein: Complex Functions of AMOTL1 Gene Products., PMID:36768425
The role of Motin family proteins in tumorigenesis-an update., PMID:36973516
SRSF3/AMOTL1 splicing axis promotes the tumorigenesis of nasopharyngeal carcinoma through regulating the nucleus translocation of YAP1., PMID:37558679
Circ-AMOTL1 enhances cardiac fibrosis through binding with EIF4A3 and stabilizing MARCKS expression in diabetic cardiomyopathy., PMID:37586467
Hsa_circ_0001278 Facilitates Colorectal Cancer Progression via Sponging miR-338-5p and Regulating AMOTL1 Expression., PMID:38018210
Hypomethylation of Wnt signaling regulator genes in developmental language disorder., PMID:38264859
circ-Amotl1 in extracellular vesicles derived from ADSCs improves wound healing by upregulating SPARC translation., PMID:38318480
The cellular localization and oncogenic or tumor suppressive effects of angiomiotin-like protein 2 in tumor and normal cells., PMID:38717123
Angiomotin family proteins in the Hippo signaling pathway., PMID:38760875
Role of angiomotin family members in human diseases (Review)., PMID:38766307
Acetylcytidine modification of Amotl1 by N-acetyltransferase 10 contributes to cardiac fibrotic expansion in mice after myocardial infarction., PMID:38839936
Biliary atresia: insights into mechanisms using a toxic model of the disease including Wnt and Hippo signaling pathways and microtubules., PMID:38914763
AMOTL1 -Associated Multiple Congenital Anomalies (Craniofaciocardiohepatic Syndrome, CFCHS): A Novel Clinical Spectrum Including Craniofacial, Heart and Liver Abnormalities., PMID:39538375
Harnessing machine learning and multi-omics to explore tumor evolutionary characteristics and the role of AMOTL1 in prostate cancer., PMID:39643184
For research use only. Not for human or drug use.
