Catalog No.
YHK52301
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Thr162-Thr266
Predicted molecular weight
24.22 kDa
Nature
Recombinant
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9H7Z3
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Nuclear exosome regulator NRDE2, Protein NRDE2 homolog, C14orf102, NRDE2
Note
For research use only.
A functional homing endonuclease in the Bacillus anthracis nrdE group I intron., PMID:17496101
Small regulatory RNAs inhibit RNA polymerase II during the elongation phase of transcription., PMID:20543824
Gene silencing: small RNAs control RNA polymerase II elongation., PMID:20833310
A pre-mRNA-associating factor links endogenous siRNAs to chromatin regulation., PMID:21901112
Nuclear RNAi maintains heritable gene silencing in Caenorhabditis elegans., PMID:22106253
Genome-wide characterization of circulating tumor cells identifies novel prognostic genomic alterations in systemic melanoma metastasis., PMID:24718909
Caenorhabditis elegans RSD-2 and RSD-6 promote germ cell immortality by maintaining small interfering RNA populations., PMID:25258416
lin-4 and the NRDE pathway are required to activate a transgenic lin-4 reporter but not the endogenous lin-4 locus in C. elegans., PMID:29324872
NRDE-2, the human homolog of fission yeast Nrl1, prevents DNA damage accumulation in human cells., PMID:29902117
Human nuclear RNAi-defective 2 (NRDE2) is an essential RNA splicing factor., PMID:30538148
NRDE2 negatively regulates exosome functions by inhibiting MTR4 recruitment and exosome interaction., PMID:30842217
Identification of proteins associated with splicing factors Ntr1, Ntr2, Brr2 and Gpl1 in the fission yeast Schizosaccharomyces pombe., PMID:31219728
Chromatin Compaction by Small RNAs and the Nuclear RNAi Machinery in C. elegans., PMID:31227740
Kaposi's Sarcoma-Associated Herpesvirus Fine-Tunes the Temporal Expression of Late Genes by Manipulating a Host RNA Quality Control Pathway., PMID:32376621
Stealing the Show: KSHV Hijacks Host RNA Regulatory Pathways to Promote Infection., PMID:32937781
A Conserved NRDE-2/MTR-4 Complex Mediates Nuclear RNAi in Caenorhabditis elegans., PMID:33055090
Antisense ribosomal siRNAs inhibit RNA polymerase I-directed transcription in C. elegans., PMID:34365510
The nuclear Argonaute HRDE-1 directs target gene re-localization and shuttles to nuage to promote small RNA-mediated inherited silencing., PMID:37083324
Mouse nuclear RNAi-defective 2 promotes splicing of weak 5' splice sites., PMID:37137667
A germline-targeted genetic screen for xrn-2 suppressors identifies a novel gene C34C12.2 in Caenorhabditis elegans., PMID:37216322
Genome-wide association and environmental suppression of the mortal germline phenotype of wild C. elegans., PMID:37983674
NRDE2 deficiency impairs homologous recombination repair and sensitizes hepatocellular carcinoma to PARP inhibitors., PMID:38697125
For research use only. Not for human or drug use.
