Catalog No.
YHK50901
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Gly246
Predicted molecular weight
30.61 kDa
Nature
Recombinant
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9UPT5
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
KIAA1067, EXO70, EXOC7, Exocyst complex component Exo70, Exocyst complex component 7
Note
For research use only.
Exo70 subunit of the exocyst complex is involved in adhesion-dependent trafficking of caveolin-1., PMID:23300727
Exo70 generates membrane curvature for morphogenesis and cell migration., PMID:23948253
par-1, atypical pkc, and PP2A/B55 sur-6 are implicated in the regulation of exocyst-mediated membrane trafficking in Caenorhabditis elegans., PMID:24192838
GTP hydrolysis of TC10 promotes neurite outgrowth through exocytic fusion of Rab11- and L1-containing vesicles by releasing exocyst component Exo70., PMID:24223996
Exo70E2 is essential for exocyst subunit recruitment and EXPO formation in both plants and animals., PMID:24307681
Exo70 isoform switching upon epithelial-mesenchymal transition mediates cancer cell invasion., PMID:24331928
A role for exocyst in maturation and bactericidal function of staphylococci-containing endothelial cell phagosomes., PMID:25040264
Preliminary characterisation of nanotubes connecting T-cells and their use by HIV-1., PMID:25130443
Modulation of alternative splicing by expression of small nuclear ribonucleoprotein polypeptide N., PMID:25238490
The exocyst is required for trypanosome invasion and the repair of mechanical plasma membrane wounds., PMID:25380822
The Exocyst at a Glance., PMID:26240175
GIV/girdin binds exocyst subunit-Exo70 and regulates exocytosis of GLUT4 storage vesicles., PMID:26514725
Deciphering Mineral Homeostasis in Barley Seed Transfer Cells at Transcriptional Level., PMID:26536247
Exo70 is transcriptionally up-regulated by hepatic nuclear factor 4α and contributes to cell cycle control in hepatoma cells., PMID:26848864
Cortactin and Exo70 mediated invasion of hepatoma carcinoma cells by MMP-9 secretion., PMID:27025610
Oncogenic BRAF-Mediated Melanoma Cell Invasion., PMID:27210749
Sec8 modulates TGF-β induced EMT by controlling N-cadherin via regulation of Smad3/4., PMID:27769780
A targeted RNAi screen identifies factors affecting diverse stages of receptor-mediated transcytosis., PMID:28069747
The role of Exo70 in exocytosis and beyond., PMID:28489961
The role of Exo70 in vascular smooth muscle cell migration., PMID:28536622
Exo70 is an independent prognostic factor in colon cancer., PMID:28698570
Interleukin-6 determines protein stabilization of DNA methyltransferases and alters DNA promoter methylation of genes associated with insulin signaling and angiogenesis., PMID:29955086
PTBP1-Mediated Alternative Splicing Regulates the Inflammatory Secretome and the Pro-tumorigenic Effects of Senescent Cells., PMID:29990503
Drosophila Exo70 Is Essential for Neurite Extension and Survival under Thermal Stress., PMID:30209205
The Exocyst Component Exo70 Modulates Dendrite Arbor Formation, Synapse Density, and Spine Maturation in Primary Hippocampal Neurons., PMID:30374940
Kinase suppressor of Ras 1 and Exo70 promote fatty acid-stimulated neurotensin secretion through ERK1/2 signaling., PMID:30917119
SNV discovery and functional candidate gene identification for milk composition based on whole genome resequencing of Holstein bulls with extremely high and low breeding values., PMID:31369641
Inducible Exoc7/Exo70 knockout reveals a critical role of the exocyst in insulin-regulated GLUT4 exocytosis., PMID:31740584
ULK1 phosphorylates Exo70 to suppress breast cancer metastasis., PMID:31913283
Listeria monocytogenes exploits host exocytosis to promote cell-to-cell spread., PMID:32015134
Regulation of human cerebral cortical development by EXOC7 and EXOC8, components of the exocyst complex, and roles in neural progenitor cell proliferation and survival., PMID:32103185
Appraising the Value of Serum and Serum-Derived Exosomal LncRNA-EXOC7 as a Promising Biomarker in Cervical Cancer., PMID:32658426
Exocyst components promote an incompatible interaction between Glycine max (soybean) and Heterodera glycines (the soybean cyst nematode)., PMID:32929168
A fine balance between Prpf19 and Exoc7 in achieving degradation of aggregated protein and suppression of cell death in spinocerebellar ataxia type 3., PMID:33542212
Lithium enhances exercise-induced glycogen breakdown and insulin-induced AKT activation to facilitate glucose uptake in rodent skeletal muscle., PMID:33660027
Androgen receptor decreases renal cell carcinoma bone metastases via suppressing the osteolytic formation through altering a novel circEXOC7 regulatory axis., PMID:33783995
An active tethering mechanism controls the fate of vesicles., PMID:34521845
Shigella flexneri subverts host polarized exocytosis to enhance cell-to-cell spread., PMID:34608697
Identification of Alternative Splicing Events Associated with Paratuberculosis in Dairy Cattle Using Multi-Tissue RNA Sequencing Data., PMID:35328051
A novel nonsense variant in EXOC8 underlies a neurodevelopmental disorder., PMID:35460391
Identification of Common Hub Genes in Human Dermal Fibroblasts Stimulated by Mechanical Stretch at Both the Early and Late Stages., PMID:35510126
Cancer cells resist antibody-mediated destruction by neutrophils through activation of the exocyst complex., PMID:35728876
Regulation of EGF-stimulated activation of the PI-3K/AKT pathway by exocyst-mediated exocytosis., PMID:36417441
Deletion of Exoc7, but not Exoc3, in male germ cells causes severe spermatogenesis failure with spermatocyte aggregation in mice., PMID:38325858
Identification of candidate regulatory genes for intramuscular fatty acid composition in pigs by transcriptome analysis., PMID:38347496
TGM1/3-mediated transamidation of Exo70 promotes tumor metastasis upon LKB1 inactivation., PMID:39146185
LncRNA ZNF649-AS1 promotes trastuzumab resistance and TAM-dependent PD-L1 expression in breast cancer by regulating EXOC7 alternative splicing., PMID:39159899
TC10 differently controls the dynamics of Exo70 in growth cones of cortical and hippocampal neurons., PMID:39521348
Exocyst complex component 1 (Exoc1) loss in dormant oocyte disrupts c-KIT and growth differentiation factor (GDF9) subcellular localization and causes female infertility in mice., PMID:39833146
Identification of m6A-modified gene signatures in lung adenocarcinoma tumorigenesis and their potential role in drug resistance., PMID:40131660
For research use only. Not for human or drug use.
