Catalog No.
YHD91801
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Arg22-Lys231
Predicted molecular weight
26.75 kDa
Nature
Recombinant
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P30926
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
CHRNB4, Neuronal acetylcholine receptor subunit beta-4
Note
For research use only.
Case of autoimmune autonomic ganglionopathy manifesting anhidrosis., PMID:28620980
[Polymorphic Variants of Glutamate Receptor (GRIK5, GRIN2B) and Serotonin Receptor (HTR2A) Genes Are Associated with Chronic Obstructive Pulmonary Disease]., PMID:28900078
Assessing causal relationships using genetic proxies for exposures: an introduction to Mendelian randomization., PMID:28921935
Association Between rs1051730 and Smoking During Pregnancy in Dutch Women., PMID:29228387
The Psychiatric Risk Gene Transcription Factor 4 (TCF4) Regulates Neurodevelopmental Pathways Associated With Schizophrenia, Autism, and Intellectual Disability., PMID:29228394
Association and cis-mQTL analysis of variants in CHRNA3-A5, CHRNA7, CHRNB2, and CHRNB4 in relation to nicotine dependence in a Chinese Han population., PMID:29666375
The role of nicotinic receptor genes (CHRN) in the pathways of prenatal tobacco exposure on smoking behavior among young adult light smokers., PMID:29751336
Exploring the role of low-frequency and rare exonic variants in alcohol and tobacco use., PMID:29758381
Genetic modifiers of radon-induced lung cancer risk: a genome-wide interaction study in former uranium miners., PMID:29971594
CHRNA3 rs1051730 and CHRNA5 rs16969968 polymorphisms are associated with heavy smoking, lung cancer, and chronic obstructive pulmonary disease in a mexican population., PMID:29993116
A dominant role for the beta 4 nicotinic receptor subunit in nicotinic modulation of glomerular microcircuits in the mouse olfactory bulb., PMID:30089021
Genome-Wide Variants Shared Between Smoking Quantity and Schizophrenia on 15q25 Are Associated With CHRNA5 Expression in the Brain., PMID:30202994
Druggability of Coronary Artery Disease Risk Loci., PMID:30354342
Combined genetic influence of the nicotinic receptor gene cluster CHRNA5/A3/B4 on nicotine dependence., PMID:30453884
Evolution of vertebrate nicotinic acetylcholine receptors., PMID:30700248
Conditional Dicer1 depletion using Chrnb4-Cre leads to cone cell death and impaired photopic vision., PMID:30783126
Variants in the CHRNA5-CHRNA3-CHRNB4 Region of Chromosome 15 Predict Gastrointestinal Adverse Events in the Transdisciplinary Tobacco Use Research Center Smoking Cessation Trial., PMID:30882151
The role of the nAChR subunits α5, β2, and β4 on synaptic transmission in the mouse superior cervical ganglion., PMID:30891952
Toxicogenomic analyses of the effects of BDE-47/209, TBBPA/S and TCBPA on early neural development with a human embryonic stem cell in vitro differentiation system., PMID:31326446
[Analysis of polymorphism rs1051730 of CHRNA3 in patients with dual pathology in a Mexican population]., PMID:31588985
Pharmacological targeting of α3β4 nicotinic receptors improves peripheral insulin sensitivity in mice with diet-induced obesity., PMID:32140744
β4-Nicotinic Receptors Are Critically Involved in Reward-Related Behaviors and Self-Regulation of Nicotine Reinforcement., PMID:32184221
An Integrated Genomic Strategy to Identify CHRNB4 as a Diagnostic/Prognostic Biomarker for Targeted Therapy in Head and Neck Cancer., PMID:32455963
Genetic susceptibility to nicotine addiction: Advances and shortcomings in our understanding of the CHRNA5/A3/B4 gene cluster contribution., PMID:32738310
Dissecting the genetic overlap of smoking behaviors, lung cancer, and chronic obstructive pulmonary disease: A focus on nicotinic receptors and nicotine metabolizing enzyme., PMID:32803792
Validating Fluorescent Chrnb4.EGFP Mouse Models for the Study of Cone Photoreceptor Degeneration., PMID:32879784
Colocalization of association signals at nicotinic acetylcholine receptor genes between schizophrenia and smoking traits., PMID:33454625
The relationship between CHRNA5/A3/B4 gene cluster polymorphisms and lung cancer risk: An updated meta-analysis and systematic review., PMID:33578531
Nicotinic acetylcholine gene cluster CHRNA5-A3-B4 variants influence smoking status in a Bangladeshi population., PMID:33675519
Genetics of substance use disorders: a review., PMID:33879270
Chr15q25 Genetic Variant rs16969968 Alters Cell Differentiation in Respiratory Epithelia., PMID:34206324
Application of Bioinformatics Methods to Identify Key Genes and Functions in Chronic Pelvic Pain., PMID:34381521
Five New Cases of Megacystis-Microcolon-Intestinal Hypoperistalsis Syndrome (MMIHS), with One Case Showing a Novel Mutation., PMID:34383618
A polygenic approach to the association between smoking and schizophrenia., PMID:34779080
Several nAChRs gene variants are associated with phenotypes of heroin addiction in Chinese Han population., PMID:35176404
Divergent Roles of α5 and β4 Nicotinic Receptor Subunits in Food Reward and Nicotine-induced Weight Loss in Male Mice., PMID:35595472
Integrative RNA profiling of TBEV-infected neurons and astrocytes reveals potential pathogenic effectors., PMID:35685361
The mu opioid receptor and the orphan receptor GPR151 contribute to social reward in the habenula., PMID:36424418
CHRNA5-A3-B4 and DRD2 Genes and Smoking Cessation Throughout Adulthood: A Longitudinal Study of Women., PMID:36794842
Are novel treatments for brain disorders hiding in plain sight?, PMID:37422511
Bioinformatic Analysis on the Prognostic Value of Neurotransmitter Receptor-Related Genes in Kidney Renal Clear Cell Carcinoma., PMID:37632962
Neonicotinoids differentially modulate nicotinic acetylcholine receptors in immature and antral follicles in the mouse ovary†., PMID:38713677
Investigating CHRNA5, CHRNA3, and CHRNB4 variants in the genetic landscape of substance use disorder in Jordan., PMID:38862938
Abundant extrasynaptic expression of α3β4-containing nicotinic acetylcholine receptors in the medial habenula-interpeduncular nucleus pathway in mice., PMID:38902419
Cannabinol (CBN) Influences the Ion Channels and Synaptic-Related Genes in NSC-34 Cell Line: A Transcriptomic Study., PMID:39329756
CHRNA5-A3-B4, CYP2A6, and DBH Genetic Associations With Smoking Cessation Throughout Adulthood Within Two Longitudinal Studies of Women., PMID:39673390
Novel Transgenic Zebrafish Lines to Study the CHRNA3-B4-A5 Gene Cluster., PMID:39686588
Repurposing of dipeptidyl peptidase FDA-approved drugs in Alzheimer's disease using network pharmacology and in-silico approaches., PMID:39938415
Nicotinic acetylcholine receptors regulate growth hormone in pituitary somatotrophs of tigers., PMID:40164859
Association of SNPs in nAChRs genes, areca nut chewing and smoking, and their interaction with lung cancer in Hainan, China: a case control study., PMID:40197297
For research use only. Not for human or drug use.
