Catalog No.
YHH35901
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Gln45-Gly179
Predicted molecular weight
17.39 kDa
Nature
Recombinant
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q16739
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
GLCT-1, UDP-glucose ceramide glucosyltransferase, Glucosylceramide synthase, UDP-glucose:N-acylsphingosine D-glucosyltransferase, UGCG, GCS, Ceramide glucosyltransferase
Note
For research use only.
The relevance of ceramides and their synthesizing enzymes for multiple sclerosis., PMID:30219773
Optic Nerve Lipidomics Reveal Impaired Glucosylsphingosine Lipids Pathway in Glaucoma., PMID:31022733
Adipocytes harbor a glucosylceramide biosynthesis pathway involved in iNKT cell activation., PMID:31051284
Ganglioside deficiency in hypothalamic POMC neurons promotes body weight gain., PMID:31168055
UGCG influences glutamine metabolism of breast cancer cells., PMID:31666638
A role for ceramide glycosylation in resistance to oxaliplatin in colorectal cancer., PMID:31972222
Gangliosides modulate insulin secretion by pancreatic beta cells under glucose stress., PMID:32149357
Inhibition of glycosphingolipid biosynthesis reverts multidrug resistance by differentially modulating ABC transporters in chronic myeloid leukemias., PMID:32229586
Changes in long-chain fatty acid composition of milk fat globule membrane and expression of mammary lipogenic genes in dairy cows fed sunflower seeds and rumen-protected choline., PMID:32410273
Arrayed CRISPR Screening Identifies Novel Targets That Enhance the Productive Delivery of mRNA by MC3-Based Lipid Nanoparticles., PMID:32441189
Endogenous levels of 1-O-acylceramides increase upon acidic ceramidase deficiency and decrease due to loss of Dgat1 in a tissue-dependent manner., PMID:32474112
Bioinformatic analysis and experimental identification of blood biomarkers for chronic nonunion., PMID:32503597
The sirtuin inhibitor cambinol reduces intracellular glucosylceramide with ceramide accumulation by inhibiting glucosylceramide synthase., PMID:32705968
Roles of Gangliosides in Hypothalamic Control of Energy Balance: New Insights., PMID:32731387
Study on the differentially expressed genes and signaling pathways in dermatomyositis using integrated bioinformatics method., PMID:32846838
Identification of long-term survival-associated gene in breast cancer., PMID:33080569
Metabolic engineering of HEK293 cells to improve transient transfection and cell budding of HIV-1 virus-like particles., PMID:33463716
Platelet autophagic machinery involved in thrombosis through a novel linkage of AMPK-MTOR to sphingolipid metabolism., PMID:33749503
A genome-wide CRISPR/Cas9 screen to identify phagocytosis modulators in monocytic THP-1 cells., PMID:34155263
Glucosylceramide synthase deficiency in the heart compromises β1-adrenergic receptor trafficking., PMID:34297830
Four Immune-Related Genes (FN1, UGCG, CHPF2 and THBS2) as Potential Diagnostic and Prognostic Biomarkers for Carbon Nanotube-Induced Mesothelioma., PMID:34511983
ECHS1, an interacting protein of LASP1, induces sphingolipid-metabolism imbalance to promote colorectal cancer progression by regulating ceramide glycosylation., PMID:34615856
Increased glucosylceramide production leads to decreased cell energy metabolism and lowered tumor marker expression in non-cancerous liver cells., PMID:34626204
Blockade of Glycosphingolipid Synthesis Inhibits Cell Cycle and Spheroid Growth of Colon Cancer Cells In Vitro and Experimental Colon Cancer Incidence In Vivo., PMID:34638879
UDP-Glucose Ceramide Glycosyltransferase Contributes to the Proliferation and Glycolysis of Cervical Cancer Cells by Regulating the PI3K/AKT Pathway., PMID:34686508
In vitro profiling of toxic effects of environmental polycyclic aromatic hydrocarbons on nuclear receptor signaling, disruption of endogenous metabolism and induction of cellular stress., PMID:34843781
Inhibition of Ceramide Glycosylation Enhances Cisplatin Sensitivity in Cholangiocarcinoma by Limiting the Activation of the ERK Signaling Pathway., PMID:35330102
Dysregulated sphingolipid metabolism and autophagy in granulosa cells of women with endometriosis., PMID:35992117
The Sphingolipids Metabolism Mechanism and Associated Molecular Biomarker Investigation in Keloid., PMID:36321232
Targeting UGCG Overcomes Resistance to Lysosomal Autophagy Inhibition., PMID:36331284
ST3GAL5-catalyzed gangliosides inhibit TGF-β-induced epithelial-mesenchymal transition via TβRI degradation., PMID:36504224
A sensitive method for determining UDP-glucose: ceramide glucosyltransferase (UGCG) activity in biological samples using deuterated glucosylceramide as acceptor substrate., PMID:36504340
Salvianolic acid B suppresses hepatic fibrosis by inhibiting ceramide glucosyltransferase in hepatic stellate cells., PMID:36627345
Glucosylceramide is essential for Heartland and Dabie bandavirus glycoprotein-induced membrane fusion., PMID:36920967
Ligand Activation of the Aryl Hydrocarbon Receptor Upregulates Epidermal Uridine Diphosphate Glucose Ceramide Glucosyltransferase and Glucosylceramides., PMID:37004877
Therapeutic Mechanism of Baicalin in Experimental Colitis Analyzed Using Network Pharmacology and Metabolomics., PMID:37025160
Role of lipid metabolism gene KLF4 in osteoarthritis., PMID:37608136
Effects of Ureaplasma parvum infection in the exosome biogenesis-related proteins in ectocervical epithelial cells., PMID:38282606
Targeting glucosylceramide synthase induces antiproliferative and proapoptotic effects in osimertinib-resistant NSCLC cell models., PMID:38499619
Peripheral Upregulation of Parkinson's Disease-Associated Genes Encoding α-Synuclein, β-Glucocerebrosidase, and Ceramide Glucosyltransferase in Major Depression., PMID:38542193
Dysregulated lipid metabolism networks modulate T-cell function in people with relapsing-remitting multiple sclerosis., PMID:38625017
Ceramide metabolism alterations contribute to Tumor Necrosis Factor-induced melanoma dedifferentiation and predict resistance to immune checkpoint inhibitors in advanced melanoma patients., PMID:39136013
Divergent effects of acute and chronic PPT1 inhibition in melanoma., PMID:39265628
UDP-glucose ceramide glucosyltransferase specifically upregulated in plasmacytoid dendritic cells regulates type I interferon production upon CpG stimulation., PMID:39307111
Inhibiting UGCG prevents PRV infection by decreasing lysosome-associated autophage., PMID:39631580
SLO co-opts host cell glycosphingolipids to access cholesterol-rich lipid rafts for enhanced pore formation and cytotoxicity., PMID:39835825
Miglustat ameliorates isoproterenol-induced cardiac fibrosis via targeting UGCG., PMID:39934657
Bombyx mori nuclear polyhedrosis virus infection regulated by host glycosphingolipids., PMID:40262890
ɑ1,3-mannosyltransferase promotes the malignant progression of bladder cancer through activating TNF signaling pathway., PMID:40312703
Sphingolipid metabolism-related genes as diagnostic markers in pneumonia-induced sepsis: the AUG model., PMID:40394027
For research use only. Not for human or drug use.
