Anti-LYN Polyclonal Antibody

Catalog No.

PHC28801

Species reactivity

Human, Mouse, Rat

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human LYN (Met263-Asp491).

Tested applications

ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000

Target

Lck/Yes-related novel protein tyrosine kinase,p53Lyn,JTK8,p56Lyn,Tyrosine-protein kinase Lyn,LYN,V-yes-1 Yamaguchi sarcoma viral related oncogene homolog

Purification

Purified by antigen affinity column.

Accession

P07948

Applications

ELISA, IHC, WB

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Protectin D1, an omega-3-derived lipid mediator, resolves mast cell-driven allergic inflammation via FcεRⅠ signaling., PMID:40253829

Nauclofficines A and B, two novel monoterpenoid indole alkaloids from the Li folk herb Nauclea officinalis with anti-allergic inflammatory effects on RBL-2H3 cells., PMID:39987995

Perfluorooctane sulfonate attenuates IgE/Ag-stimulated mast cell activation and anaphylactic responses via activating SHP-1 pathway., PMID:39827624

Dietary Linolenic Acid Enhances IgE Binding to Bovine α-Lactalbumin/β-Lactoglobulin and Promotes KU812 Basophil Degranulation via Upregulation of the Lyn/Syk Pathway., PMID:39772611

KIRA6 is an Effective and Versatile Mast Cell Inhibitor of IgE-mediated Activation., PMID:39676406

Aberrantly Expressed Mitochondrial Lipid Kinase, AGK, Activates JAK2-Histone H3 Axis and BCR Signal: A Mechanistic Study with Implication in CLL Therapy., PMID:39636206

CD11b deficiency attenuates the ischemia/reperfusion-induced AKI-to-CKD process by regulating macrophage polarization., PMID:39612192

Antimicrobial Peptide Pro10-1D Exhibits Anti-Allergic Activity: A Promising Therapeutic Candidate., PMID:39596204

Intra- and inter-patient diversity in hepatocellular carcinoma based on phosphorylation profiles-A pilot study in a single institution., PMID:39551467

The Evolving Role of Bruton's Tyrosine Kinase Inhibitors in B Cell Lymphomas., PMID:39062757

Aspalathin, a Primary Rooibos Flavonoid, Alleviates Mast Cell-Mediated Allergic Inflammation by the Inhibition of FcεRI Signaling Pathway., PMID:38777857

The abnormal signaling of the B cell receptor and co-receptors of lupus B cells., PMID:38636889

TLR Engagement Induces an Alternate Pathway for BCR Signaling that Results in PKCδ Phosphorylation., PMID:38629913

B-Cell Receptor Signaling and Beyond: The Role of Igα (CD79a)/Igβ (CD79b) in Normal and Malignant B Cells., PMID:38203179

B-1a Cells, but Not Marginal Zone B Cells, Are Implicated in the Accumulation of Autoreactive Plasma Cells in Lyn-/- Mice., PMID:38189742

Regulation of mast cells by overlapping but distinct protein interactions of Siglec-6 and Siglec-8., PMID:38186079

Inhibitory effects of catalpol on DNCB-induced atopic dermatitis and IgE-mediated mast cells reaction., PMID:38041954

PI3Kδ activation, IL6 over-expression, and CD37 loss cause resistance to the targeting of CD37-positive lymphomas with the antibody-drug conjugate naratuximab emtansine., PMID:38014209

Validation of a murine proteome-wide phage display library for identification of autoantibody specificities., PMID:37934865

Targeting BMI-1 to deplete antibody-secreting cells in autoimmunity., PMID:37799772

TNFα counteracts interleukin-10 anti-inflammatory pathway through the NOX2-Lyn-SHP-1 axis in human monocytes., PMID:37757542

STAP-2 negatively regulates BCR-mediated B cell activation by recruiting tyrosine-protein kinase CSK to LYN., PMID:37669828

Molecular basis for potent B cell responses to antigen displayed on particles of viral size., PMID:37653247

Focal adhesion kinase activation by calcium-dependent calpain is involved in chronic lymphocytic leukaemia cell aggressiveness., PMID:37495265

Effects and potential mechanisms of Saposhnikovia divaricata (Turcz.) Schischk. On type I allergy and pseudoallergic reactions in vitro and in vivo., PMID:37487961

MYD88L265P augments proximal B-cell receptor signaling in large B-cell lymphomas via an interaction with DOCK8., PMID:37467575

Genome-wide association analyses define pathogenic signaling pathways and prioritize drug targets for IgA nephropathy., PMID:37337107

Anti-inflammatory effect of dictamnine on allergic rhinitis via suppression of the LYN kinase-mediated molecular signaling pathway during mast cell activation., PMID:37329155

T-bet-expressing B cells contribute to the autoreactive plasma cell pool in Lyn-/- mice., PMID:37134326

Analysis of intracellular tyrosine phosphorylation in circulating neutrophils as a rapid assay for the in vivo effect of oral tyrosine kinase inhibitors., PMID:37089957

Validation of a murine proteome-wide phage display library for the identification of autoantibody specificities., PMID:37066405

Luxeptinib interferes with LYN-mediated activation of SYK and modulates BCR signaling in lymphoma., PMID:36888611

Multistep IgE Mast Cell Desensitization Is a Dose- and Time-Dependent Process Partially Regulated by SHIP-1., PMID:36881903

Gastroprotective action of the extract of Corydalis yanhusuo in Helicobacter pylori infection and its bioactive component, dehydrocorydaline., PMID:36681166

Chemical composition-based characterization of the anti-allergic effect of Guominkang Formula on IgE-mediated mast cells activation and passive cutaneous anaphylaxis., PMID:36549806

Functional Characterization of Largemouth Bass (Micropterus salmoides) Soluble FcγR Homolog in Response to Bacterial Infection., PMID:36430268

Daphnetin contributes to allergen-induced Th2 cytokine expression and type 2-immune responses in atopic dermatitis and asthma., PMID:36373505

Signal peptide-CUB-EGF-like repeat-containing protein 1-promoted FLT3 signaling is critical for the initiation and maintenance of MLL-rearranged acute leukemia., PMID:36005562

Multifunctional regulation of VAMP3 in exocytic and endocytic pathways of RBL-2H3 cells., PMID:35990647

Salicylaldehyde Suppresses IgE-Mediated Activation of Mast Cells and Ameliorates Anaphylaxis in Mice., PMID:35955959

Interfering B cell receptor signaling via SHP-1/p-Lyn axis shows therapeutic potential in diffuse large B-cell lymphoma., PMID:35941532

Effects of Cyclosporine A and Adalimumab on the expression profiles histaminergic system-associated genes and microRNAs regulating these genes in HaCaT cells., PMID:35899934

Network pharmacology-based analysis of the mechanism of Saposhnikovia divaricata for the treatment of type I allergy., PMID:35760567

Fumarate suppresses B-cell activation and function through direct inactivation of LYN., PMID:35710616

Serial Tumor Molecular Profiling of Newly Diagnosed HER2-Negative Breast Cancers During Chemotherapy in Combination with Angiogenesis Inhibitors., PMID:35699834

Clustering extent-dependent differential signaling by CLEC-2 receptors in platelets., PMID:35573643

Modeling the B-cell receptor signaling on single cell level reveals a stable network circuit topology between nonmalignant B cells and chronic lymphocytic leukemia cells and between untreated cells and cells treated with kinase inhibitors., PMID:35527719

A dominant function of LynB kinase in preventing autoimmunity., PMID:35452291

AMG853, A Bispecific Prostaglandin D2 Receptor 1 and 2 Antagonist, Dampens Basophil Activation and Related Lupus-Like Nephritis Activity in Lyn-Deficient Mice., PMID:35444641

Role of inhibitory signaling in peripheral B cell tolerance., PMID:35128676

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