Catalog No.
YHD59901
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Pro232-Arg461
Predicted molecular weight
28.90 kDa
Nature
Recombinant
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P23677
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Inositol-trisphosphate 3-kinase A, IP3K A, ITPKA, IP3 3-kinase A, Inositol 1,4,5-trisphosphate 3-kinase A, InsP 3-kinase A
Note
For research use only.
Localization of the genes for human inositol 1,4,5-trisphosphate 3-kinase A (ITPKA) and B (ITPKB) to chromosome regions 15q14-q21 and 1q41-q43, respectively, by in situ hybridization., PMID:1330886
Down-regulation of 1D-myo-inositol 1,4,5-trisphosphate 3-kinase A protein expression in oral squamous cell carcinoma., PMID:16525636
The absence of expression of the three isoenzymes of the inositol 1,4,5-trisphosphate 3-kinase does not prevent the formation of inositol pentakisphosphate and hexakisphosphate in mouse embryonic fibroblasts., PMID:17355905
Neuronal IP3 3-kinase is an F-actin-bundling protein: role in dendritic targeting and regulation of spine morphology., PMID:19846664
Inositol 1,4,5-trisphosphate 3-kinase-A is a new cell motility-promoting protein that increases the metastatic potential of tumor cells by two functional activities., PMID:20022963
Somatostatin is involved in anorexia in mice fed a valine-deficient diet., PMID:21293891
Expression Regulation of the Metastasis-Promoting Protein InsP3-Kinase-A in Tumor Cells., PMID:21460179
RNAi-based screening identifies kinases interfering with dioxin-mediated up-regulation of CYP1A1 activity., PMID:21479225
Functional role of inositol-1,4,5-trisphosphate-3-kinase-A for motility of malignant transformed cells., PMID:21792881
Inositol-1,4,5-trisphosphate 3-kinase A regulates dendritic morphology and shapes synaptic Ca2+ transients., PMID:22120525
Candidate genes in ocular dominance plasticity., PMID:22347157
Identification of p130Cas/ErbB2-dependent invasive signatures in transformed mammary epithelial cells., PMID:23839042
Identification of a new membrane-permeable inhibitor against inositol-1,4,5-trisphosphate-3-kinase A., PMID:23981806
Stimulation of MMP-1 and CCL2 by NAMPT in PDL cells., PMID:24058270
Gene and isoform expression signatures associated with tumor stage in kidney renal clear cell carcinoma., PMID:24564989
Enhanced expression and purification of inositol 1,4,5-trisphosphate 3-kinase A through use of the pCold1-GST vector and a C-terminal hexahistidine tag in Escherichia coli., PMID:24576661
The catalytic domain of inositol-1,4,5-trisphosphate 3-kinase-a contributes to ITPKA-induced modulation of F-actin., PMID:25620569
Regulation of NGF-driven neurite outgrowth by Ins(1,4,5)P3 kinase is specifically associated with the two isoenzymes Itpka and Itpkb in a model of PC12 cells., PMID:25892505
Inositol(1,4,5)P3 3-kinase isoenzymes: Catalytic properties and importance of targeting to F-actin to understand function., PMID:26446452
Inositol-1,4,5-trisphosphate-3-kinase-A controls morphology of hippocampal dendritic spines., PMID:26519023
Specific expression and function of inositol 1,4,5-trisphosphate 3-kinase C (ITPKC) in wild type and knock-out mice., PMID:27036498
Inositol-1,4,5-trisphosphate 3-kinase-A (ITPKA) is frequently over-expressed and functions as an oncogene in several tumor types., PMID:28377279
Mining the glioma susceptibility genes in children from gene expression profiles and a methylation database., PMID:28927102
Effect of the actin- and calcium-regulating activities of ITPKB on the metastatic potential of lung cancer cells., PMID:29871874
Molecular signatures in IASLC/ATS/ERS classified growth patterns of lung adenocarcinoma., PMID:30352093
PKA-dependent phosphorylation of IP3K-A at Ser119 regulates a binding affinity with EB3., PMID:30466786
Maternal Choline Supplementation Alters Basal Forebrain Cholinergic Neuron Gene Expression in the Ts65Dn Mouse Model of Down Syndrome., PMID:31120189
Utility of Circulating Cell-Free RNA Analysis for the Characterization of Global Transcriptome Profiles of Multiple Myeloma Patients., PMID:31242667
Transcriptional correlates of the pathological phenotype in a Huntington's disease mouse model., PMID:31822756
TFAP2A Induced ITPKA Serves as an Oncogene and Interacts with DBN1 in Lung Adenocarcinoma., PMID:32015686
Cumulus cell gene expression in luteal-phase-derived oocytes after double stimulation in one menstrual cycle., PMID:32593508
Physiological relevance of the neuronal isoform of inositol-1,4,5-trisphosphate 3-kinases in mice., PMID:32593773
Mouse Ataxin-2 Expansion Downregulates CamKII and Other Calcium Signaling Factors, Impairing Granule-Purkinje Neuron Synaptic Strength., PMID:32932600
An eleven metabolic gene signature-based prognostic model for clear cell renal cell carcinoma., PMID:33221754
The role of 5-HT7R in the memory impairment of mice induced by long-term isoflurane anesthesia., PMID:35032676
A Class I HDAC Inhibitor BG45 Alleviates Cognitive Impairment through the CaMKII/ITPKA/Ca2+ Signaling Pathway., PMID:36558932
The actin bundling activity of ITPKA mainly accounts for its migration-promoting effect in lung cancer cells., PMID:36688944
Therapeutic targets for inflammatory bowel disease: proteome-wide Mendelian randomization and colocalization analyses., PMID:36857861
Commentary on: The actin bundling activity of ITPKA mainly accounts for its migration-promoting effect in lung cancer cells., PMID:37664985
Transcriptomic Landscape of Circulating Extracellular Vesicles in Heart Transplant Ischemia-Reperfusion., PMID:38003044
RETRACTED: Exploring the tumor microenvironment: Chemokine-related genes and immunotherapy/chemotherapy response in clear-cell renal cell carcinoma., PMID:38488671
Identification of potential drug targets for allergic diseases from a genetic perspective: A mendelian randomization study., PMID:38573314
ITPKA phosphorylates PYCR1 and promotes the progression of glioma., PMID:39170313
The Role of Epicardial Adipose Tissue-Derived Proteins in Heart Failure with Preserved Ejection Fraction and Atrial Fibrillation: A Bioinformatics Analysis., PMID:39257896
Genetic insights into visceral obesity with health conditions, from disease susceptibility to therapeutic intervention., PMID:39835424
Spatial Transcriptomics and Proteomics Profiling After Ischemic Stroke Reperfusion: Insights Into Vascular Alterations., PMID:40052263
For research use only. Not for human or drug use.
