Catalog No.
YHA03601
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Lys205-Asp246
Predicted molecular weight
32.95 kDa
Nature
Recombinant
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O00165
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
HS1BP1, HS1-binding protein 1, HAX1, HSP1BP-1, HCLS1-associated protein X-1, HS1-associating protein X-1, HAX-1
Note
For research use only.
HAX1 maintains the glioma progression in hypoxia through promoting mitochondrial fission., PMID:34755451
Suppression of Kv3.3 channels by antisense oligonucleotides reverses biochemical effects and motor impairment in spinocerebellar ataxia type 13 mice., PMID:34820911
Role of haematopoietic cell-specific protein 1-associated protein X-1 gene in lipopolysaccharide-induced apoptosis of human dermal fibroblasts., PMID:34826355
Hsa-miR223-3p circulating level is upregulated in Friedreich's ataxia and inversely associated with HCLS1 associated protein X-1, HAX-1., PMID:35015850
Effect of different expression patterns of HAX-1 on the proliferation and apoptosis of human astrocyte., PMID:35302298
Anti-apoptotic HAX-1 suppresses cell apoptosis by promoting c-Abl kinase-involved ROS clearance., PMID:35379774
HAX1-dependent control of mitochondrial proteostasis governs neutrophil granulocyte differentiation., PMID:35499078
Extracellular vesicles rich in HAX1 promote angiogenesis by modulating ITGB6 translation., PMID:35524442
Hax-1 Regulates Radiation-Induced Mitochondrial-Dependent Apoptosis of Uveal Melanoma Cells through PI3K/AKT/eNOS Pathway., PMID:35602302
Long chain noncoding RNA-ROR promotes hypoxic injury of cardiomyocytes by targeting the miR-145/HAX-1 axis., PMID:35693619
Aberrant PLN-R14del Protein Interactions Intensify SERCA2a Inhibition, Driving Impaired Ca2+ Handling and Arrhythmogenesis., PMID:35805951
The Clinical and Molecular Assessment of Iranian Families with Severe Congenital Neutropenia, Identification of HYOU1 and SHOC2 as Potential Novel Gene Defects., PMID:35822684
The Landscape of Liver Chromatin Accessibility and Conserved Non-coding Elements in Larimichthys crocea, Nibea albiflora, and Lateolabrax maculatus., PMID:35895229
Human genetic defects in SRP19 and SRPRA cause severe congenital neutropenia with distinctive proteome changes., PMID:36223592
The RNA-Binding Landscape of HAX1 Protein Indicates Its Involvement in Translation and Ribosome Assembly., PMID:36230905
PYCR in Kidney Renal Papillary Cell Carcinoma: Expression, Prognosis, Gene Regulation Network, and Regulation Targets., PMID:36624948
Long Noncoding RNA Cytoskeleton Regulator RNA Suppresses Apoptosis in Hepatoma Cells by Modulating the miR-125a-5p/HS1-Associated Protein X-1 Axis to Induce Caspase-9 Inactivation., PMID:36700300
Severe congenital neutropenia, SRP54 pathogenicity, and a framework for surveillance., PMID:36815775
Historical Cohort of Severe Congenital Neutropenia in Iran: Clinical Course, Laboratory Evaluation, Treatment, and Survival., PMID:37053506
HAX1-related congenital neutropenia: Long-term observation in paediatric and adult patients enrolled in the European branch of the Severe Chronic Neutropenia International Registry (SCNIR)., PMID:37193639
Gentianella acuta-derived Gen-miR-1 suppresses myocardial fibrosis by targeting HAX1/HMG20A/Smads axis to attenuate inflammation in cardiac fibroblasts., PMID:37352750
Hypothermic oxygenated perfusion attenuates DCD liver ischemia-reperfusion injury by activating the JAK2/STAT3/HAX1 pathway to regulate endoplasmic reticulum stress., PMID:37438690
HAX1: A versatile, intrinsically disordered regulatory protein., PMID:37454914
CircGFPT1 regulates the growth and apoptosis of esophageal squamous cell carcinoma through miR-142-5p/HAX1 axis., PMID:37455293
Hax1 regulate focal adhesion dynamics through IQGAP1., PMID:37488602
NOD1 cooperates with HAX-1 to promote cell migration in a RIPK2- and NF-ĸB-independent manner., PMID:37488967
Germline Variants Incidentally Detected via Tumor-Only Genomic Profiling of Patients With Mesothelioma., PMID:37556141
African swine fever virus MGF360-9L promotes viral replication by degrading the host protein HAX1., PMID:37640268
An innate immune sensor wandering around - NOD1 promotes cell migration via non-canonical signaling., PMID:37735823
HAX1 is a novel binding partner of Che-1/AATF. Implications in oxidative stress cell response., PMID:37742722
Functional annotation with expression validation identifies novel metastasis-relevant genes from post-GWAS risk loci in sporadic colorectal carcinomas., PMID:37890997
Interactome profiling of Crimean-Congo hemorrhagic fever virus glycoproteins., PMID:37963884
Screening for ELANE, HAX1 and GFI1 gene mutations in children with neutropenia and clinical characterization of two novel mutations in ELANE gene., PMID:37993852
The metabolic basis of inherited neutropenias., PMID:38049194
Cav-1 regulates the bile salt export pump on the canalicular membrane of hepatocytes by PKCα-associated signalling under cholesterol stimulation., PMID:38164042
CLPB disaggregase dysfunction impacts the functional integrity of the proteolytic SPY complex., PMID:38270563
Impact of different genetic mutations on granulocyte development and G-CSF responsiveness in congenital neutropenia., PMID:38286463
The EIF3H-HAX1 axis increases RAF-MEK-ERK signaling activity to promote colorectal cancer progression., PMID:38514606
Genetic backgrounds and clinical characteristics of congenital neutropenias in Israel., PMID:38600884
HAX1-Overexpression Augments Cardioprotective Efficacy of Stem Cell-Based Therapy Through Mediating Hippo-Yap Signaling., PMID:38713406
Energy stress promotes P-bodies formation via lysine-63-linked polyubiquitination of HAX1., PMID:38769438
HAX-1 interferes in assembly of NLRP3-ASC to block microglial pyroptosis in cerebral I/R injury., PMID:38811533
Molecular functions of HAX1 during disease progress., PMID:38992331
Interaction with the cysteine-free protein HAX1 expands the substrate specificity and function of MIA40 beyond protein oxidation., PMID:39564806
Mitochondrial CLPB is a pro-survival factor at the onset of granulocytic differentiation of mouse myeloblastic cells., PMID:39644357
A Little Known but Very Common Phenotype in Patients With Severe Congenital Neutropenia Due to HAX1 Deficiency: Premature Ovarian Insufficiency., PMID:39980410
IGF2BP1-HAX-1 positive feedback loop-mediated HAX-1 overexpression blocks autophagic flux and promotes chemoresistance in nasopharyngeal carcinoma., PMID:40055185
Cerebrospinal fluid proteomics identification of biomarkers for amyloid and tau PET stages., PMID:40118053
PA and PA-X: two key proteins from segment 3 of the influenza viruses., PMID:40160474
Activation of a Potassium Channel Mutation That Causes Spinocerebellar Ataxia Promotes Aggregation of the RhoGEF Domain-Containing Protein Plekhg4., PMID:40249242
For research use only. Not for human or drug use.
