Catalog No.
YHF83601
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Asp296-Lys462
Predicted molecular weight
21.11 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q00839
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
C1orf199, GRIP120, pp120, Scaffold-attachment factor A, p120, SAFA, Nuclear p120 ribonucleoprotein, hnRNP U, SAF-A, Heterogeneous nuclear ribonucleoprotein U, HNRNPU, HNRPU, U21.1
Role of the SAF-A/HNRNPU SAP domain in X chromosome inactivation, nuclear dynamics, transcription, splicing, and cell proliferation., PMID:40493679
Dual prophylactic and therapeutic potential of iPSC-based vaccines and neoantigen discovery in colorectal cancer., PMID:40365296
The anti-metastatic effect of elemene in human hepatocellular carcinoma is potentially mediated by inhibiting a novel driver-circBPTF., PMID:40347926
Bioinformatics Analysis of the Expression and Prognostic Significance of Transcription Factor YY1 in Gastric Cancer., PMID:40088083
Identification of NIBAN2-Regulated RUNX2 Alternative Splicing Presents Novel Strategies for Antagonizing Osteoporosis., PMID:40051391
Expanding the Phenotypic Spectrum of HNRNPU-Related Disorder, Documenting the First Familial Presentation and Comprehensive Review., PMID:39976380
An anti-cell migration compound that binds to hnRNP U and suppresses nuclear deformation., PMID:39899942
The nuclear matrix stabilizes primed-specific genes in human pluripotent stem cells., PMID:39789220
MSC-derived exosomal circMYO9B accelerates diabetic wound healing by promoting angiogenesis through the hnRNPU/CBL/KDM1A/VEGFA axis., PMID:39725699
The ALS-associated co-chaperone DNAJC7 mediates neuroprotection against proteotoxic stress by modulating HSF1 activity., PMID:39651147
CTCF enhances pancreatic cancer progression via FLG-AS1-dependent epigenetic regulation and macrophage polarization., PMID:39616247
LncRNA evf-2 Exacerbates Podocyte Injury in Diabetic Nephropathy by Inducing Cell Cycle Re-entry and Inflammation Through Distinct Mechanisms Triggered by hnRNPU., PMID:39470303
Deacetylation of HnRNP U mediated by sirtuin1 ameliorates aged rat with liver fibrosis via inhibiting p53-related senescence and NLRP3-related inflammation., PMID:39216234
Leveraging multi-omics data to infer regulators of mRNA 3' end processing in glioblastoma., PMID:39188787
Analysis of the Upregulated Expression Mechanism of Apoptotic Chromatin Condensation Inducer 1 in Hepatocellular Carcinoma Based on Bioinformatics., PMID:39128105
Pathogenic gene connections in type 2 diabetes and non-alcoholic fatty liver disease: a bioinformatics analysis and mouse model investigations experiments., PMID:39107295
The nuclear matrix protein HNRNPU restricts hepatitis B virus transcription by promoting OAS3-based activation of host innate immunity., PMID:39011773
The RNA-binding Selectivity of the RGG/RG Motifs of hnRNP U is Abolished by Elements Within the C-terminal Intrinsically Disordered Region., PMID:38996909
ASAR lncRNAs control DNA replication timing through interactions with multiple hnRNP/RNA binding proteins., PMID:38896448
Loss of HNRNPU in Skeletal Muscle Increases Intramuscular Infiltration of Ly6C Positive Cells, leading to Muscle Atrophy through Activation of NF-κB Signaling., PMID:38797891
High-throughput proteomic analysis of extracellular vesicles from saliva by chemical probe-based array., PMID:38772652
Lactylome analyses suggest systematic lysine-lactylated substrates in oral squamous cell carcinoma under normoxia and hypoxia., PMID:38750680
Decreased RNA-binding protein heterogeneous nuclear ribonucleoprotein U improves multiple myeloma sensitivity to lenalidomide., PMID:38685577
TM7SF3 controls TEAD1 splicing to prevent MASH-induced liver fibrosis., PMID:38670107
Alternative splicing of CARM1 regulated by LincGET-guided paraspeckles biases the first cell fate in mammalian early embryos., PMID:38658621
hnRNPU is required for spermatogonial stem cell pool establishment in mice., PMID:38625792
Circular RNA CircSLC22A23 Promotes Gastric Cancer Progression by Activating HNRNPU Expression., PMID:38400886
RNA Binding Proteins that Mediate LPS-induced Alternative Splicing of the MyD88 Innate Immune Regulator., PMID:38369277
Genome-wide ATAC-see screening identifies TFDP1 as a modulator of global chromatin accessibility., PMID:38361031
ITGA9-AS1 up-regulates ITGA9 by targeting miR-4765 and recruiting HNRNPU to affect the proliferation and apoptosis of non-small cell lung cancer cells., PMID:38279497
circ-hnRNPU inhibits NONO-mediated c-Myc transactivation and mRNA stabilization essential for glycosylation and cancer progression., PMID:37993881
RNA-binding protein hnRNPU regulates multiple myeloma resistance to selinexor., PMID:37984724
Alternative Splicing Factor Heterogeneous Nuclear Ribonucleoprotein U as a Promising Biomarker for Gastric Cancer Risk and Prognosis with Tumor-Promoting Properties., PMID:37923250
FAM171B stabilizes vimentin and enhances CCL2-mediated TAM infiltration to promote bladder cancer progression., PMID:37915048
Deficiency of the Heterogeneous Nuclear Ribonucleoprotein U locus leads to delayed hindbrain neurogenesis., PMID:37815090
Neurodevelopmental deficits and cell-type-specific transcriptomic perturbations in a mouse model of HNRNPU haploinsufficiency., PMID:37782669
Human lncRNA SUGCT-AS1 Regulates the Proinflammatory Response of Macrophage., PMID:37686120
The identification of key genes and pathways in glioblastoma by bioinformatics analysis., PMID:37593751
HNRNPU's multi-tasking is essential for proper cortical development., PMID:37439444
Germline pathogenic variants in HNRNPU are associated with alterations in blood methylome., PMID:37407733
piRNA-1742 promotes renal cell carcinoma malignancy by regulating USP8 stability through binding to hnRNPU and thereby inhibiting MUC12 ubiquitination., PMID:37332045
Splicing factors in the heart: Uncovering shared and unique targets., PMID:37059416
SAF-A/hnRNP U binds polyphosphoinositides via a lysine rich polybasic motif located in the SAP domain., PMID:37038481
Functional analysis of hepatic long non-coding ribonucleic acids during liver transplantation in humans., PMID:36967627
HNRNPU facilitates antibody class-switch recombination through C-NHEJ promotion and R-loop suppression., PMID:36943867
p38-mediated FOXN3 phosphorylation modulates lung inflammation and injury through the NF-κB signaling pathway., PMID:36794705
Heterogeneous Nuclear Protein U Degraded the m6A Methylated TRAF3 Transcript by YTHDF2 To Promote Porcine Epidemic Diarrhea Virus Replication., PMID:36752613
[Clinical significance and pathogenesis analysis of heterogeneous nuclear ribonucleoprotein U in acute myeloid leukemia]., PMID:36709168
SR Protein Kinase 1 Inhibition by TAF15., PMID:36611919
LncRNA IL21-AS1 interacts with hnRNPU protein to promote IL21 overexpression and aberrant differentiation of Tfh cells in systemic lupus erythematosus., PMID:36447054
For research use only. Not for human or drug use.
