Catalog No.
YHK45401
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ala2-Arg50
Predicted molecular weight
33.79 kDa
Nature
Recombinant
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q99941
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
CREBL1, Protein G13, cAMP-responsive element-binding protein-like 1, Activating transcription factor 6 beta, cAMP response element-binding protein-related protein, Cyclic AMP-dependent transcription factor ATF-6 beta, G13, ATF6B, Creb-rp, ATF6-beta, cAMP-dependent transcription factor ATF-6 beta
Note
For research use only.
Opposing roles for ATF6alpha and ATF6beta in endoplasmic reticulum stress response gene induction., PMID:14973138
Use of a cAMP BRET sensor to characterize a novel regulation of cAMP by the sphingosine 1-phosphate/G13 pathway., PMID:17283075
Applications of counter-current chromatography in organic synthesis purification of heterocyclic derivatives of lapachol., PMID:17408681
Effects of the isoform-specific characteristics of ATF6 alpha and ATF6 beta on endoplasmic reticulum stress response gene expression and cell viability., PMID:17522056
G13-dependent activation of MAPK by thyrotropin., PMID:18445595
The G protein betagamma subunit mediates reannealing of adherens junctions to reverse endothelial permeability increase by thrombin., PMID:19917775
Activation status of integrated stress response pathways in neurones and astrocytes of HIV-associated neurocognitive disorders (HAND) cortex., PMID:21883374
Inhibition of ATF6β-dependent host adaptive immune response by a Toxoplasma virulence factor ROP18., PMID:22286708
Acute activation of β2-adrenergic receptor regulates focal adhesions through βArrestin2- and p115RhoGEF protein-mediated activation of RhoA., PMID:22500016
Transcriptional regulation of mouse mesencephalic astrocyte-derived neurotrophic factor in Neuro2a cells., PMID:23864333
Antitumor effects with apoptotic death in human promyelocytic leukemia HL-60 cells and suppression of leukemia xenograft tumor growth by irinotecan HCl., PMID:24474168
Measurement of the unfolded protein response to investigate its role in adipogenesis and obesity., PMID:24529437
MicroRNA-31 controls G protein alpha-13 (GNA13) expression and cell invasion in breast cancer cells., PMID:25889182
Cutting Edge: Synchronization of IRF1, JunB, and C/EBPβ Activities during TLR3-TLR7 Cross-Talk Orchestrates Timely Cytokine Synergy in the Proinflammatory Response., PMID:26109639
Placental endoplasmic reticulum stress negatively regulates transcription of placental growth factor via ATF4 and ATF6β: implications for the pathophysiology of human pregnancy complications., PMID:26648175
Unfolded protein response in hypothalamic cultures of wild-type and ATF6α-knockout mice., PMID:26708632
ICECREAM: randomised phase II study of cetuximab alone or in combination with irinotecan in patients with metastatic colorectal cancer with either KRAS, NRAS, BRAF and PI3KCA wild type, or G13D mutated tumours., PMID:27246726
The unfolded protein response genes in human osteoarthritic chondrocytes: PERK emerges as a potential therapeutic target., PMID:27435272
Effects of muscular dystrophy, exercise and blocking activin receptor IIB ligands on the unfolded protein response and oxidative stress., PMID:27554968
ATF6β-based fine-tuning of the unfolded protein response enhances therapeutic antibody productivity of Chinese hamster ovary cells., PMID:28165157
Homocysteine levels associate with subtle changes in leukocyte DNA methylation: an epigenome-wide analysis., PMID:28990796
Transcriptional differences between smokers and non-smokers and variance by obesity as a risk factor for human sensitivity to environmental exposures., PMID:29459183
Paradoxical roles of ATF6α and ATF6β in modulating disease severity caused by mutations in collagen X., PMID:29522813
Reproductive risk factors in breast cancer and genetic hormonal pathways: a gene-environment interaction in the MCC-Spain project., PMID:29530003
Overlapping and differential functions of ATF6α versus ATF6β in the mouse heart., PMID:30765833
Crebl2 regulates cell metabolism in muscle and liver cells., PMID:31882710
Multiexon deletion alleles of ATF6 linked to achromatopsia., PMID:32271167
Polymorphism in the 3'-UTR of LIF but Not in the ATF6B Gene Associates with Schizophrenia Susceptibility: a Case-Control Study and In Silico Analyses., PMID:32504404
G12/13 is activated by acute tethered agonist exposure in the adhesion GPCR ADGRL3., PMID:32778842
Establishment of a reporter system for monitoring activation of the ER stress transducer ATF6β., PMID:33894672
G protein-coupled receptors can control the Hippo/YAP pathway through Gq signaling., PMID:34114695
The ATF6β-calreticulin axis promotes neuronal survival under endoplasmic reticulum stress and excitotoxicity., PMID:34158584
A comparative transcriptome and proteomics study of post-partum ovarian cycle arrest in yaks (Bos grunniens)., PMID:34850471
Integrated bioinformatics and statistical approaches to explore molecular biomarkers for breast cancer diagnosis, prognosis and therapies., PMID:35617355
Arsenic Activates the ER Stress-Associated Unfolded Protein Response via the Activating Transcription Factor 6 in Human Bronchial Epithelial Cells., PMID:35625704
Enhanced metabolism and negative regulation of ER stress support higher erythropoietin production in HEK293 cells., PMID:35705050
Targeting UPR signaling pathway by dasatinib as a promising therapeutic approach in chronic myeloid leukemia., PMID:35716222
Loss of ATF6α in a human carcinoma cell line is compensated not by its paralogue ATF6β but by sustained activation of the IRE1 and PERK arms for tumor growth in nude mice., PMID:36696173
ATF6β Deficiency Elicits Anxiety-like Behavior and Hyperactivity Under Stress Conditions., PMID:36853481
Salivary proteins offer insights into keratinocyte death during aphthous stomatitis. A case-crossover study., PMID:37170213
Preservation of ∼12-hour ultradian rhythms of gene expression of mRNA and protein metabolism in the absence of canonical circadian clock., PMID:37205336
Preservation of ∼12-h ultradian rhythms of gene expression of mRNA and protein metabolism in the absence of canonical circadian clock., PMID:37324401
Evaluation of genetic risk, its clinical manifestation and disease management based on 18 susceptibility gene markers among West-Slavonic patients with sarcoidosis., PMID:37336276
Serum Induces the Subunit-Specific Activation of NF-κB in Proliferating Human Cardiac Stem Cells., PMID:38612406
Genetic associations in ankylosing spondylitis: circulating proteins as drug targets and biomarkers., PMID:38835753
CRISPR-Cas9-Mediated ATF6B Gene Editing Enhances Membrane Protein Production in HEK293T Cells., PMID:40281769
Impact of ATF6 deletion on the embryonic brain development., PMID:40487428
For research use only. Not for human or drug use.
