Catalog No.
YHG54501
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ser407-Asn565
Predicted molecular weight
20.12 kDa
Nature
Recombinant
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q13469
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
NFAT pre-existing subunit, NFATc2, Nuclear factor of activated T-cells, cytoplasmic 2, NF-ATc2, T-cell transcription factor NFAT1, NFATC2, NF-ATp, NFAT1, NFATP
Note
For research use only.
Aspalathin, a key flavonoid in rooibos, restores STAT6-mediated immune dysregulation in atopic dermatitis., PMID:39970731
"Betaone" barley water extract suppresses ovariectomy-induced osteoporosis in vivo and RANKL-induced osteoclast differentiation in vitro., PMID:39982961
STIM1-mediated NFAT signaling synergizes with STAT1 to control T-bet expression and TH1 differentiation., PMID:39984734
Occlusion of TCR binding to HLA-A*11:01 by a non-pathogenic human alloantibody., PMID:40009199
The NAE1-mediated neddylation operates as an essential post-translational modification checkpoint for effector CD8+ T cells., PMID:40030035
Astrocytic GluN2A alleviates sleep deprivation-induced elevation of Aβ through regulating neprilysin and AQP4 via the calcineurin/NFAT pathway., PMID:40032156
A Cutaneous Vascular Neoplasm With an EWSR1-NFATC2 Translocation-Contributing to the Spectrum of Vascular Lesions Characterized by NFATC-Related Fusions., PMID:40037835
NFAT2 Induces Tumor Cell Proliferation and Metastasis by Acting as a Transcriptional Co-activator of the TGF-β1/SMAD Signaling Pathway and Inducing the Epithelial-Mesenchymal Transition in Liver Cancer., PMID:40038210
DPHB inhibits osteoclastogenesis by suppressing NF-κB and MAPK signaling and alleviates inflammatory bone destruction., PMID:40043357
Long non-coding RNA-MIR181A1HG acts as an oncogene and contributes to invasion and metastasis in gastric cancer., PMID:40044982
Exon junction complexes regulate osteoclast-induced bone resorption by influencing the NFATc1 m6A distribution through the "shield effect"., PMID:40051055
Knockout of Trpc6 attenuates T2DM-induced liver injury and inflammation by inhibiting CN-NFAT2-NLRP3 signalling in mice., PMID:40056751
Quercetagetin alleviates inflammatory osteoclastogenesis and collagen antibody-induced arthritis via Nrf2 signaling and Pten/AKT/Nfatc1 axis., PMID:40057805
[Effect and mechanism of acupotomy tendon-sparing and knot-dissolving technique in inhibiting bone destruction in rats with rheumatoid arthritis based on the PI3K/AKT/NFATc1 pathway]., PMID:40059046
Linagliptin Mitigates DMH-Induced Colorectal Cancer in Rats: Crosstalk Between NFAT and IL-6/JAK2/STAT3/NF-κB Signaling Hubs., PMID:40070168
Mechanical stretch promotes the neutrophil recruitment potential of fibroblasts through the Piezo/NFAT1/LIF axis., PMID:40086612
IRF2BP2 deficiency: An important form of common variable immunodeficiency with inflammation., PMID:40090425
3-Hydroxybutyrate Promotes Myoblast Proliferation and Differentiation through Energy Metabolism and GPR109a-Mediated Ca2+-NFAT Signaling Pathways., PMID:40099866
Dominant interfering CARD11 variants disrupt JNK signaling to promote GATA3 expression in T cells., PMID:40111223
Cardiomyocytic FoxP3 Attenuates Expression of β Isoform of Myosin Heavy Chain During Cardiac Hypertrophy and Effects of Triptolide., PMID:40123330
STIM1 in-frame deletion of eight amino acids in a patient with moderate tubular aggregate myopathy/Stormorken syndrome., PMID:40127930
Differential regulation of calcium-NFAT signaling pathway by Akt isoforms: unraveling effector dynamics and exhaustion of cytotoxic T lymphocytes in tumor microenvironment., PMID:40139836
Effects of low-level laser irradiation on osteoclastogenesis in prostaglandin E2-stimulated macrophages., PMID:40153082
[Hypericin ameliorates stress-induced depressive-like behaviors in mice by modulating the CN-NFAT calcium signaling pathway in microglia]., PMID:40159965
Targeted Dual Microdroplets for Modulating Osteoclast Differentiation and Function: A Novel Therapeutic Approach to Combat Osteoporosis., PMID:40181685
Thiotaurine inhibits melanoma progression by enhancing Ca2+ overload-induced cellular apoptosis., PMID:40189970
Nat10-mediated N4-acetylcytidine modification enhances Nfatc1 translation to exacerbate osteoclastogenesis in postmenopausal osteoporosis., PMID:40193598
Identification of anti-resorptive GPCRs by high-content imaging in human osteoclasts., PMID:40215127
Visualization and Quantification of NFAT1 Translocation in T Cells., PMID:40220223
Utility of Protein Kinase C Beta II Immunohistochemistry in Differential Diagnosis of Ewing Sarcoma., PMID:40230184
[Research progress on the role of CaN/NFAT signaling pathway activated by Ca2+ overload in hypertensive cardiac hypertrophy]., PMID:40255011
IL-10 alleviates aTCMR by inhibiting NFATc1 signaling pathway of T cells after kidney transplantation., PMID:40268206
Chrysin improves endothelial inflammation via the NFAT pathway in Kawasaki disease., PMID:40285837
NFAT2 promotes sorafenib resistance in hepatocellular carcinoma cells by modulating calcium ion signalling., PMID:40288600
Orai1 Participates in Coronary Artery Dysfunction Caused by Hypertension via Regulating Smooth Muscle Cell Phenotype Transformation., PMID:40293813
During high salt treatment myeloid p38α/MAPK fosters osteoclast activity and inflammatory macrophage responses promoting orthodontic tooth movement., PMID:40303394
Genkwanin blocks the interaction between phosphorylated JNK and NFATc1 to promote osteogenic differentiation and collagen Ⅰ α1 production., PMID:40311832
Diagnostic Utility of NKX3.1 in Mesenchymal Chondrosarcoma on Needle Biopsy: A Case Report of a Supraclavicular Soft Tissue Mass with Literature Review., PMID:40323235
Maltol promotes osteoclastogenesis and exacerbates periodontitis via TRAF6/JNK/Nfatc1 pathway., PMID:40373380
Lonicerin targets ADRA1D and RSPO3 to ameliorate diabetes-induced vascular injury through Ca2+/Calcineurin/NFAT1-dependent anti-EndMT pathway., PMID:40398181
Polysaccharides from Psoralea corylifolia seeds suppress osteoclastogenesis and alleviate osteoporosis., PMID:40403806
Brevilin A, a novel BNIP3 inhibitor suppresses osteoclastogenesis and prevents ovariectomy-induced bone loss via impairing mitophagy and mitochondrial metabolism., PMID:40408943
MafB regulates hair follicle stem cell activation and hair regeneration through NFATc1 signaling pathway., PMID:40414006
Kujigamberol Inhibits IFN-γ and IL-2 mRNA Expression and NFATc2 Binding to Their Promoters in Response to a Phorbol Ester and Ionomycin Stimulation., PMID:40430387
PIEZO1-mediated calcium signaling reinforces mechanical properties of hair follicle stem cells to promote quiescence., PMID:40435254
Lobetyolin Suppressed Osteoclastogenesis and Alleviated Bone Loss in Ovariectomy-Induced Osteoporosis via Hindering p50/p65 Nuclear Translocation and Downstream NFATc1/c-Fos Expression., PMID:40486125
Multi-parameter magnetic resonance imaging of zebularine in liver fibrosis treatment and calcineurin/NFAT3 mechanism., PMID:40495950
Soluble β-Amyloid Oligomers Selectively Upregulate TRPC3 in Excitatory Neurons via Calcineurin-Coupled NFAT., PMID:40498020
Synergistic Crosstalk of PACAP and Notch Signaling Pathways in Bone Development., PMID:40507899
NFATC2/SERPINE1/JAK3/STAT3 signaling feedback loop in gastric cancer: immune evasion and anti-PD-1 resistance., PMID:40512406
For research use only. Not for human or drug use.
